O95972 · BMP15_HUMAN

  • Protein
    Bone morphogenetic protein 15
  • Gene
    BMP15
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.

Miscellaneous

The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa).
Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum lumen
Cellular Componentextracellular space
Molecular Functioncytokine activity
Molecular Functiongrowth factor activity
Biological Processfemale gamete generation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bone morphogenetic protein 15
  • Short names
    BMP-15
  • Alternative names
    • Growth/differentiation factor 9B (GDF-9B)

Gene names

    • Name
      BMP15
    • Synonyms
      GDF9B

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O95972
  • Secondary accessions
    • Q17RM6
    • Q5JST1
    • Q9UMS1

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Involvement in disease

Ovarian dysgenesis 2 (ODG2)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
  • See also
    MIM:300510
Natural variants in ODG2
Variant IDPosition(s)ChangeDescription
VAR_021195235Y>Cin ODG2; dominant-negative effect; may cause relevant modifications in the conformation of the precursor protein possibly leading to altered processing and impaired activation of latent forms or to abnormal dimerization; dbSNP:rs104894765

Premature ovarian failure 4 (POF4)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
  • See also
    MIM:300510
Natural variants in POF4
Variant IDPosition(s)ChangeDescription
VAR_05897561R>Qin POF4
VAR_05897661R>Win POF4; dbSNP:rs144392417
VAR_05897768R>Win POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs104894763
VAR_05897876R>Cin POF4; dbSNP:rs104894766
VAR_05897976R>Hin POF4; dbSNP:rs1557279925
VAR_058981138R>Hin POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs371418883
VAR_058982148L>Pin POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs114823607
VAR_058984180A>Tin POF4; uncertain significance; no or minor deleterious effect detected; dbSNP:rs104894767
VAR_058985196N>Kin POF4
VAR_058986206R>Hin POF4; dbSNP:rs782516193
VAR_058987221W>Rin POF4; dbSNP:rs375284458
VAR_058988243I>Vin POF4; dbSNP:rs782379521
VAR_066933329R>Cin POF4; dbSNP:rs782375794

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_0589745no or minor deleterious effect observed; dbSNP:rs113099187
Natural variantVAR_05897561in POF4
Natural variantVAR_05897661in POF4; dbSNP:rs144392417
Natural variantVAR_05897768in POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs104894763
Natural variantVAR_05897876in POF4; dbSNP:rs104894766
Natural variantVAR_05897976in POF4; dbSNP:rs1557279925
Natural variantVAR_058980103in dbSNP:rs41308602
Natural variantVAR_058981138in POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs371418883
Natural variantVAR_058982148in POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs114823607
Natural variantVAR_058983180requires 2 nucleotide substitutions
Natural variantVAR_058984180in POF4; uncertain significance; no or minor deleterious effect detected; dbSNP:rs104894767
Natural variantVAR_058985196in POF4
Natural variantVAR_066932200in dbSNP:rs202165852
Natural variantVAR_058986206in POF4; dbSNP:rs782516193
Natural variantVAR_058987221in POF4; dbSNP:rs375284458
Natural variantVAR_021195235in ODG2; dominant-negative effect; may cause relevant modifications in the conformation of the precursor protein possibly leading to altered processing and impaired activation of latent forms or to abnormal dimerization; dbSNP:rs104894765
Natural variantVAR_058988243in POF4; dbSNP:rs782379521
Natural variantVAR_058989263no or minor deleterious effect detected
Natural variantVAR_066933329in POF4; dbSNP:rs782375794

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 382 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, propeptide, glycosylation, modified residue, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-18
PropeptidePRO_000003389219-267
Glycosylation87N-linked (GlcNAc...) asparagine
Glycosylation147N-linked (GlcNAc...) asparagine
Glycosylation237N-linked (GlcNAc...) asparagine
Modified residue268Pyrrolidone carboxylic acid; in P16 and P17
ChainPRO_0000033893268-392Bone morphogenetic protein 15
Modified residue273Phosphoserine; in P16
Glycosylation277O-linked (HexNAc...) threonine; in P17
Disulfide bond291↔357
Disulfide bond320↔389
Disulfide bond324↔391
Glycosylation373N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O95972DCAF6 Q58WW22EBI-12594867, EBI-2559044

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the TGF-beta family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    392
  • Mass (Da)
    45,055
  • Last updated
    2004-08-16 v2
  • Checksum
    A957275EF275A2E8
MVLLSILRILFLCELVLFMEHRAQMAEGGQSSIALLAEAPTLPLIEELLEESPGEQPRKPRLLGHSLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTNVARPHRGTWHIQILGFPLRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF082350
EMBL· GenBank· DDBJ
AAC99768.1
EMBL· GenBank· DDBJ
Genomic DNA
AF082349
EMBL· GenBank· DDBJ
AAC99768.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ132405
EMBL· GenBank· DDBJ
CAB43531.1
EMBL· GenBank· DDBJ
Genomic DNA
AL359914
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC069155
EMBL· GenBank· DDBJ
AAH69155.1
EMBL· GenBank· DDBJ
mRNA
BC117264
EMBL· GenBank· DDBJ
AAI17265.1
EMBL· GenBank· DDBJ
mRNA
BC117266
EMBL· GenBank· DDBJ
AAI17267.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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