O95972 · BMP15_HUMAN
- ProteinBone morphogenetic protein 15
- GeneBMP15
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids392 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
Miscellaneous
The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa).
Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum lumen | |
Cellular Component | extracellular space | |
Molecular Function | cytokine activity | |
Molecular Function | growth factor activity | |
Biological Process | female gamete generation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBone morphogenetic protein 15
- Short namesBMP-15
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO95972
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Involvement in disease
Ovarian dysgenesis 2 (ODG2)
- Note
- DescriptionA disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
- See alsoMIM:300510
Natural variants in ODG2
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_021195 | 235 | Y>C | in ODG2; dominant-negative effect; may cause relevant modifications in the conformation of the precursor protein possibly leading to altered processing and impaired activation of latent forms or to abnormal dimerization; dbSNP:rs104894765 |
Premature ovarian failure 4 (POF4)
- Note
- DescriptionAn ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
- See alsoMIM:300510
Natural variants in POF4
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_058975 | 61 | R>Q | in POF4 | |
VAR_058976 | 61 | R>W | in POF4; dbSNP:rs144392417 | |
VAR_058977 | 68 | R>W | in POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs104894763 | |
VAR_058978 | 76 | R>C | in POF4; dbSNP:rs104894766 | |
VAR_058979 | 76 | R>H | in POF4; dbSNP:rs1557279925 | |
VAR_058981 | 138 | R>H | in POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs371418883 | |
VAR_058982 | 148 | L>P | in POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs114823607 | |
VAR_058984 | 180 | A>T | in POF4; uncertain significance; no or minor deleterious effect detected; dbSNP:rs104894767 | |
VAR_058985 | 196 | N>K | in POF4 | |
VAR_058986 | 206 | R>H | in POF4; dbSNP:rs782516193 | |
VAR_058987 | 221 | W>R | in POF4; dbSNP:rs375284458 | |
VAR_058988 | 243 | I>V | in POF4; dbSNP:rs782379521 | |
VAR_066933 | 329 | R>C | in POF4; dbSNP:rs782375794 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_058974 | 5 | no or minor deleterious effect observed; dbSNP:rs113099187 | |||
Sequence: S → R | ||||||
Natural variant | VAR_058975 | 61 | in POF4 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_058976 | 61 | in POF4; dbSNP:rs144392417 | |||
Sequence: R → W | ||||||
Natural variant | VAR_058977 | 68 | in POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs104894763 | |||
Sequence: R → W | ||||||
Natural variant | VAR_058978 | 76 | in POF4; dbSNP:rs104894766 | |||
Sequence: R → C | ||||||
Natural variant | VAR_058979 | 76 | in POF4; dbSNP:rs1557279925 | |||
Sequence: R → H | ||||||
Natural variant | VAR_058980 | 103 | in dbSNP:rs41308602 | |||
Sequence: N → S | ||||||
Natural variant | VAR_058981 | 138 | in POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs371418883 | |||
Sequence: R → H | ||||||
Natural variant | VAR_058982 | 148 | in POF4; leads to marked reduction of mature protein production; does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein; dbSNP:rs114823607 | |||
Sequence: L → P | ||||||
Natural variant | VAR_058983 | 180 | requires 2 nucleotide substitutions | |||
Sequence: A → F | ||||||
Natural variant | VAR_058984 | 180 | in POF4; uncertain significance; no or minor deleterious effect detected; dbSNP:rs104894767 | |||
Sequence: A → T | ||||||
Natural variant | VAR_058985 | 196 | in POF4 | |||
Sequence: N → K | ||||||
Natural variant | VAR_066932 | 200 | in dbSNP:rs202165852 | |||
Sequence: H → Y | ||||||
Natural variant | VAR_058986 | 206 | in POF4; dbSNP:rs782516193 | |||
Sequence: R → H | ||||||
Natural variant | VAR_058987 | 221 | in POF4; dbSNP:rs375284458 | |||
Sequence: W → R | ||||||
Natural variant | VAR_021195 | 235 | in ODG2; dominant-negative effect; may cause relevant modifications in the conformation of the precursor protein possibly leading to altered processing and impaired activation of latent forms or to abnormal dimerization; dbSNP:rs104894765 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_058988 | 243 | in POF4; dbSNP:rs782379521 | |||
Sequence: I → V | ||||||
Natural variant | VAR_058989 | 263 | no or minor deleterious effect detected | |||
Sequence: L → LL | ||||||
Natural variant | VAR_066933 | 329 | in POF4; dbSNP:rs782375794 | |||
Sequence: R → C |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 382 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, propeptide, glycosylation, modified residue, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MVLLSILRILFLCELVLF | ||||||
Propeptide | PRO_0000033892 | 19-267 | ||||
Sequence: MEHRAQMAEGGQSSIALLAEAPTLPLIEELLEESPGEQPRKPRLLGHSLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTNVARPHRGTWHIQILGFPLRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTR | ||||||
Glycosylation | 87 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 147 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 237 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 268 | Pyrrolidone carboxylic acid; in P16 and P17 | ||||
Sequence: Q | ||||||
Chain | PRO_0000033893 | 268-392 | Bone morphogenetic protein 15 | |||
Sequence: QADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR | ||||||
Modified residue | 273 | Phosphoserine; in P16 | ||||
Sequence: S | ||||||
Glycosylation | 277 | O-linked (HexNAc...) threonine; in P17 | ||||
Sequence: T | ||||||
Disulfide bond | 291↔357 | |||||
Sequence: CSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSC | ||||||
Disulfide bond | 320↔389 | |||||
Sequence: CKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESC | ||||||
Disulfide bond | 324↔391 | |||||
Sequence: CLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC | ||||||
Glycosylation | 373 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O95972 | DCAF6 Q58WW2 | 2 | EBI-12594867, EBI-2559044 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length392
- Mass (Da)45,055
- Last updated2004-08-16 v2
- ChecksumA957275EF275A2E8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF082350 EMBL· GenBank· DDBJ | AAC99768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF082349 EMBL· GenBank· DDBJ | AAC99768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ132405 EMBL· GenBank· DDBJ | CAB43531.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL359914 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC069155 EMBL· GenBank· DDBJ | AAH69155.1 EMBL· GenBank· DDBJ | mRNA | ||
BC117264 EMBL· GenBank· DDBJ | AAI17265.1 EMBL· GenBank· DDBJ | mRNA | ||
BC117266 EMBL· GenBank· DDBJ | AAI17267.1 EMBL· GenBank· DDBJ | mRNA |