FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SIX1 AND TLE3, INVOLVEMENT IN CAKUT2, VARIANTS CAKUT2 GLU-163 AND TYR-524, CHARACTERIZATION OF VARIANTS CAKUT2 GLU-163 AND TYR-524, VARIANTS THR-164 AND SER-526
Although TBX3 and TBX18 do not play a significant role in promoting the enrichment and differentiation of HiPS into sinoatrial node-like cells TBX3 shows a certain promoting trend which can be further explored in the future.
Study identified and characterized new TBX18 binding partners that may influence the transcriptional activity of TBX18 in vivo. Proteomic screen strongly supports an exclusive nuclear function of TBX18 as a repressor of chromatin accessibility.
Tbx18-positive cells represent a part of PE cells in the initial phase of differentiation and subsequently include SMCs as well as fibroblasts. These results indicate that Tbx18-positive cells serve as a PE progenitor to supply a variety of cells that contribute to the formation of coronary arteries.
Data indicate that human T-box 18 (TBX18) gene induces rat adipose-derived stem cells (ADSCs) to differentiate into pacemaker-like cells in the cardiac microenvironment.
Gene product expressions of SHH TBX18 and TSHZ3 are statistically higher in patients with UPJ obstruction when compared with control group. The explanation may be the reactivation of the processes which had shown their effects in the embryological period due to the chronic inflammation and long-term micro-trauma created by the disease
Tbx18 interacts with Gata4 and Nkx2-5 and competes Tbx5-mediated activation of the cardiac Natriuretic peptide precursor type a-promoter. Tbx18 down-regulates Tbx6-activated Delta-like 1 expression in the somitic mesoderm in vivo
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