O95785 · WIZ_HUMAN
- ProteinProtein Wiz
- GeneWIZ
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1651 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular exosome | |
Cellular Component | midbody | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | histone methyltransferase binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein-containing complex binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | transcription corepressor binding | |
Biological Process | positive regulation of nuclear cell cycle DNA replication | |
Biological Process | protein stabilization | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Ligand
Enzyme and pathway databases
The subsequence LQQKLEEVRQPPPRVRPVPSLVPRPPQTSLVKFVGNIYTLKCRFCEVEFQGPLSIQEEWVRHLQRHILEMNFSKADPPPE shows transcriptional repressor activity in a high-throughput recruitment assay.
Names & Taxonomy
Protein names
- Recommended nameProtein Wiz
- Alternative names
Gene names
- Community suggested namesWIZ
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO95785
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, cross-link, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000286054 | 1-1651 | UniProt | Protein Wiz | |||
Sequence: MEGSLAGSLAAPDRPQGPERLPGPAPRENIEGGAEAAEGEGGIFRSTRYLPVTKEGPRDILDGRGGISGTPDGRGPWEHPLVQEAGEGILSERRFEDSVIVRTMKPHAELEGSRRFLHHRGEPRLLEKHAQGRPRFDWLQDEDEQGSPQDAGLHLDLPAQPPPLAPFRRVFVPVEDTPKTLDMAVVGGREDLEDLEGLAQPSEWGLPTSASEVATQTWTVNSEASVERLQPLLPPIRTGPYLCELLEEVAEGVASPDEDEDEEPAVFPCIECSIYFKQKEHLLEHMSQHRRAPGQEPPADLAPLACGECGWAFADPTALEQHRQLHQASREKIIEEIQKLKQVPGDEGREARLQCPKCVFGTNSSRAYVQHAKLHMREPPGQTTKEPFGGSSGAGSPSPEASALLYQPYGAAVGLSACVFCGFPAPSESLLREHVRLVHAHPHWEEDGEAYEEDPASQPGTSQDAHACFPDTAVDYFGKAEPSLAPMWRENPAGYDPSLAFGPGCQQLSIRDFPLSKPLLHGTGQRPLGRLAFPSTLASTPYSLQLGRNKSTVHPQGLGERRRPWSEEEEEEEEEEDVVLTSEMDFSPENGVFSPLATPSLIPQAALELKQAFREALQAVEATQGQQQQLRGMVPIVLVAKLGPQVMAAARVPPRLQPEELGLAGAHPLDFLLLDAPLGGPLGLDTLLDGDPAMALKHEERKCPYCPDRFHNGIGLANHVRGHLNRVGVSYNVRHFISAEEVKAIERRFSFQKKKKKVANFDPGTFSLMRCDFCGAGFDTRAGLSSHARAHLRDFGITNWELTVSPINILQELLATSAAEQPPSPLGREPGGPPGSFLTSRRPRLPLTVPFPPTWAEDPGPAYGDAQSLTTCEVCGACFETRKGLSSHARSHLRQLGVAESESSGAPIDLLYELVKQKGLPDAHLGLPPGLAKKSSSLKEVVAGAPRPGLLSLAKPLDAPAVNKAIKSPPGFSAKGLGHPPSSPLLKKTPLALAGSPTPKNPEDKSPQLSLSPRPASPKAQWPQSEDEGPLNLTSGPEPARDIRCEFCGEFFENRKGLSSHARSHLRQMGVTEWYVNGSPIDTLREILKRRTQSRPGGPPNPPGPSPKALAKMMGGAGPGSSLEARSPSDLHISPLAKKLPPPPGSPLGHSPTASPPPTARKMFPGLAAPSLPKKLKPEQIRVEIKREMLPGALHGELHPSEGPWGAPREDMTPLNLSSRAEPVRDIRCEFCGEFFENRKGLSSHARSHLRQMGVTEWSVNGSPIDTLREILKKKSKPCLIKKEPPAGDLAPALAEDGPPTVAPGPVQSPLPLSPLAGRPGKPGAGPAQVPRELSLTPITGAKPSATGYLGSVAAKRPLQEDRLLPAEVKAKTYIQTELPFKAKTLHEKTSHSSTEACCELCGLYFENRKALASHARAHLRQFGVTEWCVNGSPIETLSEWIKHRPQKVGAYRSYIQGGRPFTKKFRSAGHGRDSDKRPSLGLAPGGLAVVGRSAGGEPGPEAGRAADGGERPLAASPPGTVKAEEHQRQNINKFERRQARPPDASAARGGEDTNDLQQKLEEVRQPPPRVRPVPSLVPRPPQTSLVKFVGNIYTLKCRFCEVEFQGPLSIQEEWVRHLQRHILEMNFSKADPPPEESQAPQAQTAAAEAP | |||||||
Cross-link | 11 | UniProt | In isoform O95785-3; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: A | |||||||
Cross-link | 14 | UniProt | In isoform O95785-4; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: R | |||||||
Cross-link | 29 | UniProt | In isoform O95785-3; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: N | |||||||
Cross-link | 32 | UniProt | In isoform O95785-4; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: G | |||||||
Cross-link | 39 | UniProt | In isoform O95785-3; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: G | |||||||
Cross-link | 42 | UniProt | In isoform O95785-4; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: G | |||||||
Cross-link | 258 | UniProt | In isoform O95785-3; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: E | |||||||
Cross-link | 313 | UniProt | In isoform O95785-3; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: F | |||||||
Cross-link | 883 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 939 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 955 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 967 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 968 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 982 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 983 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 988 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 989 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 996 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 996 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 998 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 998 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Cross-link | 1000 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 1005 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue | 1006 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1006 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1010 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1012 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1012 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1017 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1017 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1025 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1025 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 1056 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue | 1079 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1079 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1106 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1106 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 1108 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 1112 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 1121 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1122 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1122 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1127 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1127 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1129 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1134 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1134 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 1138 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 1139 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue | 1146 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1146 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1151 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1151 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1153 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1155 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1162 | UniProt | N6,N6,N6-trimethyllysine; by EHMT2; alternate | ||||
Sequence: K | |||||||
Modified residue | 1162 | UniProt | N6,N6-dimethyllysine; by EHMT2; alternate | ||||
Sequence: K | |||||||
Cross-link | 1177 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 1218 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 1240 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue | 1263 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1263 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 1282 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue | 1309 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1309 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1314 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1314 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1335 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1337 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Cross-link | 1343 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 1352 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 1356 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 1370 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 1372 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 1382 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 1448 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 1464 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 1477 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue | 1480 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1480 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1517 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1517 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 1523 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate | ||||
Sequence: K | |||||||
Cross-link | 1523 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate | ||||
Sequence: K | |||||||
Cross-link | 1534 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 1560 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 1629 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 1630 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region, zinc finger, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-79 | Disordered | ||||
Sequence: MEGSLAGSLAAPDRPQGPERLPGPAPRENIEGGAEAAEGEGGIFRSTRYLPVTKEGPRDILDGRGGISGTPDGRGPWEH | ||||||
Zinc finger | 267-289 | C2H2-type 1 | ||||
Sequence: FPCIECSIYFKQKEHLLEHMSQH | ||||||
Zinc finger | 304-326 | C2H2-type 2 | ||||
Sequence: LACGECGWAFADPTALEQHRQLH | ||||||
Zinc finger | 353-375 | C2H2-type 3 | ||||
Sequence: LQCPKCVFGTNSSRAYVQHAKLH | ||||||
Region | 376-399 | Disordered | ||||
Sequence: MREPPGQTTKEPFGGSSGAGSPSP | ||||||
Zinc finger | 416-439 | C2H2-type 4 | ||||
Sequence: SACVFCGFPAPSESLLREHVRLVH | ||||||
Region | 546-578 | Disordered | ||||
Sequence: LGRNKSTVHPQGLGERRRPWSEEEEEEEEEEDV | ||||||
Zinc finger | 701-723 | C2H2-type 5 | ||||
Sequence: RKCPYCPDRFHNGIGLANHVRGH | ||||||
Zinc finger | 769-791 | C2H2-type 6 | ||||
Sequence: MRCDFCGAGFDTRAGLSSHARAH | ||||||
Region | 819-843 | Disordered | ||||
Sequence: AEQPPSPLGREPGGPPGSFLTSRRP | ||||||
Zinc finger | 870-892 | C2H2-type 7 | ||||
Sequence: TTCEVCGACFETRKGLSSHARSH | ||||||
Region | 972-1038 | Disordered | ||||
Sequence: FSAKGLGHPPSSPLLKKTPLALAGSPTPKNPEDKSPQLSLSPRPASPKAQWPQSEDEGPLNLTSGPE | ||||||
Compositional bias | 1001-1019 | Polar residues | ||||
Sequence: NPEDKSPQLSLSPRPASPK | ||||||
Region | 1030-1034 | Interaction with CTBP1 and CTBP2 1 | ||||
Sequence: PLNLT | ||||||
Zinc finger | 1043-1065 | C2H2-type 8 | ||||
Sequence: IRCEFCGEFFENRKGLSSHARSH | ||||||
Region | 1091-1174 | Disordered | ||||
Sequence: RTQSRPGGPPNPPGPSPKALAKMMGGAGPGSSLEARSPSDLHISPLAKKLPPPPGSPLGHSPTASPPPTARKMFPGLAAPSLPK | ||||||
Compositional bias | 1137-1154 | Pro residues | ||||
Sequence: AKKLPPPPGSPLGHSPTA | ||||||
Region | 1214-1218 | Interaction with CTBP1 and CTBP2 2 | ||||
Sequence: PLNLS | ||||||
Zinc finger | 1227-1249 | C2H2-type 9 | ||||
Sequence: IRCEFCGEFFENRKGLSSHARSH | ||||||
Region | 1283-1331 | Disordered | ||||
Sequence: KEPPAGDLAPALAEDGPPTVAPGPVQSPLPLSPLAGRPGKPGAGPAQVP | ||||||
Compositional bias | 1303-1317 | Pro residues | ||||
Sequence: APGPVQSPLPLSPLA | ||||||
Zinc finger | 1397-1419 | C2H2-type 10 | ||||
Sequence: ACCELCGLYFENRKALASHARAH | ||||||
Region | 1463-1554 | Disordered | ||||
Sequence: TKKFRSAGHGRDSDKRPSLGLAPGGLAVVGRSAGGEPGPEAGRAADGGERPLAASPPGTVKAEEHQRQNINKFERRQARPPDASAARGGEDT | ||||||
Compositional bias | 1527-1543 | Basic and acidic residues | ||||
Sequence: HQRQNINKFERRQARPP | ||||||
Zinc finger | 1596-1622 | C2H2-type 11 | ||||
Sequence: LKCRFCEVEFQGPLSIQEEWVRHLQRH | ||||||
Region | 1629-1651 | Disordered | ||||
Sequence: SKADPPPEESQAPQAQTAAAEAP |
Domain
The C2H2-type zinc finger 11 mediates interaction with EHMT1 and EHMT2.
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
O95785-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,651
- Mass (Da)178,674
- Last updated2007-05-01 v2
- Checksum9DB0485964578310
O95785-2
- Name2
O95785-3
- Name3
- Differences from canonical
- 1-46: MEGSLAGSLAAPDRPQGPERLPGPAPRENIEGGAEAAEGEGGIFRS → MDLGSPSLPKKSLPVPGALEQVASRLSSKVAAEVPHGSKQELQDLK
- 47-865: Missing
- 1034-1034: T → TLDSDGGRELDCQLCGAWFETRKGLSSHARAHLRHLGVSDPDAKGSPIDVLHGLIRRDGVQIRLPPRRGALAHPGRPPPTSAALSLLPPPPPAKKAKLKAAGMASPWGKQDLSAAAAAGIFWASDVEPSPLNLS
O95785-4
- Name4
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8YFV2 | A0A2R8YFV2_HUMAN | WIZ | 1699 | ||
M0QXA7 | M0QXA7_HUMAN | WIZ | 968 | ||
M0QXF8 | M0QXF8_HUMAN | WIZ | 133 | ||
A0A3B3IS05 | A0A3B3IS05_HUMAN | WIZ | 96 | ||
A0A669KBG4 | A0A669KBG4_HUMAN | WIZ | 933 | ||
A0A669KBH9 | A0A669KBH9_HUMAN | WIZ | 1066 | ||
A0A669KAV7 | A0A669KAV7_HUMAN | WIZ | 1889 | ||
B9EGQ5 | B9EGQ5_HUMAN | WIZ | 832 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_054509 | 1-46 | in isoform 3 | |||
Sequence: MEGSLAGSLAAPDRPQGPERLPGPAPRENIEGGAEAAEGEGGIFRS → MDLGSPSLPKKSLPVPGALEQVASRLSSKVAAEVPHGSKQELQDLK | ||||||
Alternative sequence | VSP_057207 | 1-49 | in isoform 4 | |||
Sequence: MEGSLAGSLAAPDRPQGPERLPGPAPRENIEGGAEAAEGEGGIFRSTRY → MVAMDLGSPSLPKKSLPVPGALEQVASRLSSKVAAEVPHGSKQELQDLK | ||||||
Alternative sequence | VSP_054510 | 47-865 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_057208 | 50-865 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_024951 | 69-757 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_024952 | 867-1034 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 1001-1019 | Polar residues | ||||
Sequence: NPEDKSPQLSLSPRPASPK | ||||||
Alternative sequence | VSP_054511 | 1034 | in isoform 3 | |||
Sequence: T → TLDSDGGRELDCQLCGAWFETRKGLSSHARAHLRHLGVSDPDAKGSPIDVLHGLIRRDGVQIRLPPRRGALAHPGRPPPTSAALSLLPPPPPAKKAKLKAAGMASPWGKQDLSAAAAAGIFWASDVEPSPLNLS | ||||||
Compositional bias | 1137-1154 | Pro residues | ||||
Sequence: AKKLPPPPGSPLGHSPTA | ||||||
Compositional bias | 1303-1317 | Pro residues | ||||
Sequence: APGPVQSPLPLSPLA | ||||||
Sequence conflict | 1373 | in Ref. 2; BAD18551 | ||||
Sequence: T → A | ||||||
Compositional bias | 1527-1543 | Basic and acidic residues | ||||
Sequence: HQRQNINKFERRQARPP |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK027615 EMBL· GenBank· DDBJ | BAB55234.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK122890 EMBL· GenBank· DDBJ | BAG53783.1 EMBL· GenBank· DDBJ | mRNA | ||
AK131404 EMBL· GenBank· DDBJ | BAD18551.1 EMBL· GenBank· DDBJ | mRNA | ||
AC006128 EMBL· GenBank· DDBJ | AAC97985.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC007059 EMBL· GenBank· DDBJ | AAD19817.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC007059 EMBL· GenBank· DDBJ | AAD19818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC011492 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC002329 EMBL· GenBank· DDBJ | AAH02329.2 EMBL· GenBank· DDBJ | mRNA | ||
BC007551 EMBL· GenBank· DDBJ | AAH07551.1 EMBL· GenBank· DDBJ | mRNA | ||
BC062360 EMBL· GenBank· DDBJ | AAH62360.1 EMBL· GenBank· DDBJ | mRNA | ||
BC098445 EMBL· GenBank· DDBJ | AAH98445.1 EMBL· GenBank· DDBJ | mRNA | ||
BC144332 EMBL· GenBank· DDBJ | AAI44333.1 EMBL· GenBank· DDBJ | mRNA | ||
AL390184 EMBL· GenBank· DDBJ | CAB99102.1 EMBL· GenBank· DDBJ | mRNA |