O95544 · NADK_HUMAN
- ProteinNAD kinase
- GeneNADK
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids446 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- ATP + NAD+ = ADP + H+ + NADP+
Cofactor
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
3.3 mM | ATP | |||||
0.54 mM | NAD |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
6.7 μmol/min/mg |
pH Dependence
Optimum pH is 7.5.
Temperature Dependence
Optimum temperature is 55 degrees Celsius.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | NAD+ kinase activity | |
Biological Process | ATP metabolic process | |
Biological Process | NAD metabolic process | |
Biological Process | NADP biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO95544
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_034119 | 262 | in dbSNP:rs4751 | |||
Sequence: N → K |
Variants
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The viewer provides 453 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000120713 | 1-446 | UniProt | NAD kinase | |||
Sequence: MEMEQEKMTMNKELSPDAAAYCCSACHGDETWSYNHPIRGRAKSRSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTIMHIQDPASQRLTWNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAIASDESFGAVKKKFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKELRGKKTAVHNGLGENGSQAAGLDMDVGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDPVSDWFESLAQCLHWNVRKKQAHFEEEEEEEEEG | |||||||
Modified residue (large scale data) | 44 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 46 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 46 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 48 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 48 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 50 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 50 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 55 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 55 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 64 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 64 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed but not detected in skeletal muscle.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O95544 | CRY2 Q49AN0 | 3 | EBI-743949, EBI-2212355 | |
BINARY | O95544 | FAM124B Q9H5Z6-2 | 3 | EBI-743949, EBI-11986315 | |
BINARY | O95544 | LNX1 Q8TBB1 | 5 | EBI-743949, EBI-739832 | |
BINARY | O95544 | SDCBP O00560 | 7 | EBI-743949, EBI-727004 | |
BINARY | O95544 | YWHAZ P63104 | 3 | EBI-743949, EBI-347088 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
O95544-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length446
- Mass (Da)49,228
- Last updated1999-05-01 v1
- Checksum48CE7AF05EDD7E8B
O95544-2
- Name2
O95544-3
- Name3
- Differences from canonical
- 11-87: NKELSPDAAAYCCSACHGDETWSYNHPIRGRAKSRSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTI → GRPRVRQAWPGCCGHTGRLPAGRGYLASHMCDPAGAELIGDGMSDPTPPSNACT
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
J3KSP9 | J3KSP9_HUMAN | NADK | 44 | ||
J3KTI3 | J3KTI3_HUMAN | NADK | 74 | ||
A0A0A0MR98 | A0A0A0MR98_HUMAN | NADK | 414 | ||
J3QR86 | J3QR86_HUMAN | NADK | 30 | ||
J3QRC0 | J3QRC0_HUMAN | NADK | 38 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_047312 | 11-87 | in isoform 3 | |||
Sequence: NKELSPDAAAYCCSACHGDETWSYNHPIRGRAKSRSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTI → GRPRVRQAWPGCCGHTGRLPAGRGYLASHMCDPAGAELIGDGMSDPTPPSNACT | ||||||
Alternative sequence | VSP_047313 | 88 | in isoform 2 | |||
Sequence: M → IATPLSLASQLLPSPAVSHSGQGGVTGQVHVLPQPSDQGVLSGPRAARGQTAPQEEAVTQEEVEALVCGHTQRWVPGPVYDAAAGGSGWAQLSLRAGMGVGQATG | ||||||
Alternative sequence | VSP_047314 | 131 | in isoform 2 | |||
Sequence: E → EARGAGGKGAWGAHGVGGASIHITAPRVGSAGGMSRLALCFQ | ||||||
Sequence conflict | 363 | in Ref. 2; AAG44568 | ||||
Sequence: Missing | ||||||
Sequence conflict | 445 | in Ref. 2; BAB14412 | ||||
Sequence: E → EE | ||||||
Sequence conflict | 446 | in Ref. 3; BAH12420 | ||||
Sequence: G → EG |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY090771 EMBL· GenBank· DDBJ | AAM01195.1 EMBL· GenBank· DDBJ | mRNA | ||
AF250320 EMBL· GenBank· DDBJ | AAG44568.1 EMBL· GenBank· DDBJ | mRNA | ||
AK023114 EMBL· GenBank· DDBJ | BAB14412.1 EMBL· GenBank· DDBJ | mRNA | ||
AK290161 EMBL· GenBank· DDBJ | BAF82850.1 EMBL· GenBank· DDBJ | mRNA | ||
AK296722 EMBL· GenBank· DDBJ | BAH12420.1 EMBL· GenBank· DDBJ | mRNA | ||
AL031282 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471183 EMBL· GenBank· DDBJ | EAW56151.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471183 EMBL· GenBank· DDBJ | EAW56152.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC001709 EMBL· GenBank· DDBJ | AAH01709.1 EMBL· GenBank· DDBJ | mRNA |