O95500 · CLD14_HUMAN

  • Protein
    Claudin-14
  • Gene
    CLDN14
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbicellular tight junction
Cellular Componentendoplasmic reticulum
Cellular Componentplasma membrane
Molecular Functionidentical protein binding
Molecular Functionstructural molecule activity
Biological Processbicellular tight junction assembly
Biological Processcalcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
Biological Processcell adhesion
Biological Processprotein-containing complex assembly

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Claudin-14

Gene names

    • Name
      CLDN14
    • ORF names
      UNQ777/PRO1571

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O95500

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-7Cytoplasmic
Transmembrane8-28Helical
Topological domain29-81Extracellular
Transmembrane82-102Helical
Topological domain103-115Cytoplasmic
Transmembrane116-136Helical
Topological domain137-162Extracellular
Transmembrane163-183Helical
Topological domain184-239Cytoplasmic

Keywords

Disease & Variants

Involvement in disease

Deafness, autosomal recessive, 29 (DFNB29)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • See also
    MIM:614035
Natural variants in DFNB29
Variant IDPosition(s)ChangeDescription
VAR_06997981R>Hin DFNB29; dbSNP:rs368027306
VAR_01073885V>Din DFNB29; dbSNP:rs74315437
VAR_06998187S>Iin DFNB29
VAR_06998294A>Vin DFNB29
VAR_069983232G>Rin DFNB29; dbSNP:rs786204841

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_0172274in dbSNP:rs113831133
Natural variantVAR_06997981in DFNB29; dbSNP:rs368027306
Natural variantVAR_01073885in DFNB29; dbSNP:rs74315437
Natural variantVAR_06998086
Natural variantVAR_06998187in DFNB29
Natural variantVAR_06998294in DFNB29
Natural variantVAR_069983232in DFNB29; dbSNP:rs786204841

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 330 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001447691-239Claudin-14

Proteomic databases

PTM databases

Expression

Tissue specificity

Liver, kidney. Also found in ear.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O95500CTXN3 Q4LDR23EBI-11742599, EBI-12019274
BINARY O95500MAL P211453EBI-11742599, EBI-3932027
BINARY O95500PLLP Q9Y3423EBI-11742599, EBI-3919291

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region196-228Disordered

Sequence similarities

Belongs to the claudin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    239
  • Mass (Da)
    25,699
  • Last updated
    1999-05-01 v1
  • Checksum
    DD41652F7FD0E09A
MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQDEAPYRPYQAPPRATTTTANTAPAYQPPAAYKDNRAPSVTSATHSGYRLNDYV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ132445
EMBL· GenBank· DDBJ
CAA10669.1
EMBL· GenBank· DDBJ
Genomic DNA
AF314090
EMBL· GenBank· DDBJ
AAG60052.1
EMBL· GenBank· DDBJ
mRNA
AY355348
EMBL· GenBank· DDBJ
AAR05858.1
EMBL· GenBank· DDBJ
mRNA
AY355349
EMBL· GenBank· DDBJ
AAR05859.1
EMBL· GenBank· DDBJ
mRNA
AJ566765
EMBL· GenBank· DDBJ
CAD97762.1
EMBL· GenBank· DDBJ
mRNA
AJ566766
EMBL· GenBank· DDBJ
CAD97763.1
EMBL· GenBank· DDBJ
mRNA
AY358533
EMBL· GenBank· DDBJ
AAQ88897.1
EMBL· GenBank· DDBJ
mRNA
AP001726
EMBL· GenBank· DDBJ
BAA95509.1
EMBL· GenBank· DDBJ
Genomic DNA
BC012126
EMBL· GenBank· DDBJ
AAH12126.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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