O95382 · M3K6_HUMAN
- ProteinMitogen-activated protein kinase kinase kinase 6
- GeneMAP3K6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1288 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Activity regulation
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | MAP kinase kinase kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | protein phosphorylation | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase 6
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO95382
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_032832 | 455 | in dbSNP:rs1138294 | |||
Sequence: T → I | ||||||
Natural variant | VAR_046050 | 499 | in dbSNP:rs11247641 | |||
Sequence: R → C | ||||||
Natural variant | VAR_046051 | 544 | in dbSNP:rs55671988 | |||
Sequence: R → W | ||||||
Natural variant | VAR_032833 | 622 | in dbSNP:rs35659744 | |||
Sequence: N → K | ||||||
Natural variant | VAR_046052 | 668 | in dbSNP:rs55869163 | |||
Sequence: R → G | ||||||
Natural variant | VAR_046053 | 673 | in dbSNP:rs56359841 | |||
Sequence: R → L | ||||||
Natural variant | VAR_035629 | 869 | in a breast cancer sample; somatic mutation | |||
Sequence: P → T | ||||||
Natural variant | VAR_046054 | 925 | in a breast pleomorphic lobular carcinoma sample; somatic mutation | |||
Sequence: S → L | ||||||
Natural variant | VAR_046055 | 968 | in an ovarian endometrioid cancer sample; somatic mutation | |||
Sequence: T → I | ||||||
Natural variant | VAR_032834 | 969 | in dbSNP:rs17856498 | |||
Sequence: S → N | ||||||
Natural variant | VAR_046056 | 1061 | in dbSNP:rs55990440 | |||
Sequence: A → T | ||||||
Natural variant | VAR_046057 | 1233 | in dbSNP:rs17162549 | |||
Sequence: G → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,625 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000086251 | 1-1288 | UniProt | Mitogen-activated protein kinase kinase kinase 6 | |||
Sequence: MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLEPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIRRDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGDSQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRIRGGMVCRIWRAILAQRAGSTPVTSGP | |||||||
Modified residue (large scale data) | 783 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 806 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 931 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 957 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 964 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 964 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 984 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 984 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1129 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1129 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1144 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1149 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1149 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O95382 | SFN P31947 | 2 | EBI-1254761, EBI-476295 | |
BINARY | O95382 | YWHAE P62258 | 2 | EBI-1254761, EBI-356498 | |
BINARY | O95382 | YWHAG P61981 | 3 | EBI-1254761, EBI-359832 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 648-906 | Protein kinase | ||||
Sequence: TGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFL | ||||||
Region | 899-997 | Disordered | ||||
Sequence: TLLGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQE | ||||||
Compositional bias | 930-948 | Polar residues | ||||
Sequence: ASPTPSANSTTQSQTFPCP | ||||||
Coiled coil | 1004-1029 | |||||
Sequence: LAAVLEQELPALAENLHQEQKQEQGA | ||||||
Region | 1123-1157 | Disordered | ||||
Sequence: VEKEAVSPRSEELSNEGDSQQSPGQQSPLPVEPEQ | ||||||
Compositional bias | 1134-1151 | Polar residues | ||||
Sequence: ELSNEGDSQQSPGQQSPL | ||||||
Coiled coil | 1166-1205 | |||||
Sequence: LSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTY |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
O95382-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,288
- Mass (Da)142,596
- Last updated2009-11-03 v3
- Checksum013AF3729698080F
O95382-2
- Name2
- Differences from canonical
- 1-277: Missing
- 1065-1074: RLRAQGLGPA → WMNGEDKGSF
- 1075-1288: Missing
O95382-3
- Name3
- Differences from canonical
- 161-168: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H0Y8A3 | H0Y8A3_HUMAN | MAP3K6 | 82 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_026201 | 1-277 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_026202 | 161-168 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 435-440 | in Ref. 3; AAI29952 | ||||
Sequence: MQYYWD → ALWVPV | ||||||
Sequence conflict | 435-440 | in Ref. 3; AAI29951 | ||||
Sequence: MQYYWD → HTWVPV | ||||||
Compositional bias | 930-948 | Polar residues | ||||
Sequence: ASPTPSANSTTQSQTFPCP | ||||||
Alternative sequence | VSP_026203 | 1065-1074 | in isoform 2 | |||
Sequence: RLRAQGLGPA → WMNGEDKGSF | ||||||
Alternative sequence | VSP_026204 | 1075-1288 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 1134-1151 | Polar residues | ||||
Sequence: ELSNEGDSQQSPGQQSPL |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB167411 EMBL· GenBank· DDBJ | BAD12485.1 EMBL· GenBank· DDBJ | mRNA | ||
FO393419 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC015914 EMBL· GenBank· DDBJ | AAH15914.1 EMBL· GenBank· DDBJ | mRNA | ||
BC129950 EMBL· GenBank· DDBJ | AAI29951.1 EMBL· GenBank· DDBJ | mRNA | ||
BC129951 EMBL· GenBank· DDBJ | AAI29952.1 EMBL· GenBank· DDBJ | mRNA | ||
AB208805 EMBL· GenBank· DDBJ | BAD92042.1 EMBL· GenBank· DDBJ | mRNA | ||
AF100318 EMBL· GenBank· DDBJ | AAD05304.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |