O95371 · OR2C1_HUMAN

  • Protein
    Olfactory receptor 2C1
  • Gene
    OR2C1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanetiol (MTMT) (By similarity).
Also binds odorants acetophenone and benzaldehyde (By similarity).
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
May be involved in the molecular processes underlying fasciculation and targeting of olfactory axons (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell cortex
Cellular Componentplasma membrane
Molecular FunctionG protein-coupled receptor activity
Molecular Functionodorant binding
Molecular Functionolfactory receptor activity
Biological Processdetection of chemical stimulus involved in sensory perception of smell

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Olfactory receptor 2C1
  • Alternative names
    • OLFmf3
    • Olfactory receptor 2C2
    • Olfactory receptor OR16-1
    • Olfactory receptor OR16-2

Gene names

    • Name
      OR2C1
    • Synonyms
      OR2C2P

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O95371
  • Secondary accessions
    • A0AVA4
    • Q6IF34
    • Q6IF55

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-25Extracellular
Transmembrane26-49Helical; Name=1
Topological domain50-57Cytoplasmic
Transmembrane58-79Helical; Name=2
Topological domain80-100Extracellular
Transmembrane101-120Helical; Name=3
Topological domain121-139Cytoplasmic
Transmembrane140-158Helical; Name=4
Topological domain159-196Extracellular
Transmembrane197-219Helical; Name=5
Topological domain220-236Cytoplasmic
Transmembrane237-259Helical; Name=6
Topological domain260-272Extracellular
Transmembrane273-292Helical; Name=7
Topological domain293-312Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_04749016in dbSNP:rs1218762
Natural variantVAR_047491149in dbSNP:rs1218763
Natural variantVAR_047492229in dbSNP:rs11648783

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 429 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00001504651-312Olfactory receptor 2C1
Glycosylation5N-linked (GlcNAc...) asparagine
Disulfide bond97↔189

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    312
  • Mass (Da)
    34,412
  • Last updated
    2010-11-02 v3
  • Checksum
    33A2697D06ED8E9E
MDGVNDSSLQGFVLMGISDHPQLEMIFFIAILFSYLLTLLGNSTIILLSRLEARLHTPMYFFLSNLSSLDLAFATSSVPQMLINLWGPGKTISYGGCITQLYVFLWLGATECILLVVMAFDRYVAVCRPLRYTAIMNPQLCWLLAVIACLGGLGNSVIQSTFTLQLPLCGHRRVEGFLCEVPAMIKLACGDTSLNQAVLNGVCTFFTAVPLSIIVISYCLIAQAVLKIRSAEGRRKAFNTCLSHLLVVFLFYGSASYGYLLPAKNSKQDQGKFISLFYSLVTPMVNPLIYTLRNMEVKGALRRLLGKGREVG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF098664
EMBL· GenBank· DDBJ
AAC83557.1
EMBL· GenBank· DDBJ
Genomic DNA
AC025283
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471112
EMBL· GenBank· DDBJ
EAW85373.1
EMBL· GenBank· DDBJ
Genomic DNA
BC069456
EMBL· GenBank· DDBJ
AAH69456.1
EMBL· GenBank· DDBJ
mRNA
BC126269
EMBL· GenBank· DDBJ
AAI26270.1
EMBL· GenBank· DDBJ
mRNA
BC130328
EMBL· GenBank· DDBJ
AAI30329.1
EMBL· GenBank· DDBJ
mRNA
BK004407
EMBL· GenBank· DDBJ
DAA04805.1
EMBL· GenBank· DDBJ
Genomic DNA
BK004428
EMBL· GenBank· DDBJ
DAA04826.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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