O94991 · SLIK5_HUMAN

  • Protein
    SLIT and NTRK-like protein 5
  • Gene
    SLITRK5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Suppresses neurite outgrowth.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentglutamatergic synapse
Cellular Componentplasma membrane
Cellular Componentpostsynaptic density membrane
Cellular Componentreceptor complex
Biological Processadult behavior
Biological Processaxonogenesis
Biological Processchemical synaptic transmission
Biological Processcirculatory system development
Biological Processdendrite morphogenesis
Biological Processgrooming behavior
Biological Processpositive regulation of synapse assembly
Biological Processregulation of presynapse assembly
Biological Processregulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
Biological Processresponse to xenobiotic stimulus
Biological Processskin development
Biological Processstriatum development
Biological Processsynaptic membrane adhesion

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    SLIT and NTRK-like protein 5
  • Alternative names
    • Leucine-rich repeat-containing protein 11

Gene names

    • Name
      SLITRK5
    • Synonyms
      KIAA0918, LRRC11

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O94991
  • Secondary accessions
    • B3KNB8
    • B4DSH5
    • Q5VT81

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain41-664Extracellular
Transmembrane665-685Helical
Topological domain686-958Cytoplasmic

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,294 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Signal1-40UniProt
ChainPRO_000003268141-958UniProtSLIT and NTRK-like protein 5
Glycosylation103UniProtN-linked (GlcNAc...) asparagine
Glycosylation644UniProtN-linked (GlcNAc...) asparagine
Modified residue (large scale data)846PRIDEPhosphoserine
Modified residue (large scale data)932PRIDEPhosphotyrosine
Modified residue (large scale data)945PRIDEPhosphotyrosine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O94991BOLA2-SMG1P6 A0A087WZT33EBI-17240818, EBI-12006120
BINARY O94991CLCNKA P51800-33EBI-17240818, EBI-11980535

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat, domain, region, compositional bias.

TypeIDPosition(s)Description
Repeat82-103LRR 1
Repeat106-127LRR 2
Repeat130-151LRR 3
Repeat154-175LRR 4
Repeat178-199LRR 5
Repeat201-222LRR 6
Domain235-286LRRCT 1
Region317-358Disordered
Compositional bias339-358Polar residues
Domain365-407LRRNT
Repeat410-431LRR 7
Repeat434-455LRR 8
Repeat458-479LRR 9
Repeat482-503LRR 10
Repeat506-527LRR 11
Repeat529-550LRR 12
Domain563-614LRRCT 2
Region789-844Disordered
Compositional bias795-812Pro residues

Sequence similarities

Belongs to the SLITRK family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

O94991-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    958
  • Mass (Da)
    107,486
  • Last updated
    2004-04-13 v2
  • Checksum
    69E71DC1EE3C568B
MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGGASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKLNVEPDYLEVLEKQTTFSQF

O94991-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-31: MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVT → MGAGKHREGGGGDPTSLNGCADLIQRRTEIS
    • 32-272: Missing

Sequence caution

The sequence BAA74941.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0566761-31in isoform 2
Alternative sequenceVSP_05667732-272in isoform 2
Compositional bias339-358Polar residues
Compositional bias795-812Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB020725
EMBL· GenBank· DDBJ
BAA74941.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK024251
EMBL· GenBank· DDBJ
BAG51280.1
EMBL· GenBank· DDBJ
mRNA
AK299744
EMBL· GenBank· DDBJ
BAG61637.1
EMBL· GenBank· DDBJ
mRNA
AL603883
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471085
EMBL· GenBank· DDBJ
EAX08917.1
EMBL· GenBank· DDBJ
Genomic DNA
BC098106
EMBL· GenBank· DDBJ
AAH98106.1
EMBL· GenBank· DDBJ
mRNA
BC103509
EMBL· GenBank· DDBJ
AAI03510.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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