O94655 · YPT7_SCHPO
- ProteinYpt/Rab-type GTPase ypt7
- Geneypt7
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids205 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Ypt/Rab-type GTPases are key regulators of membrane trafficking and intracellular vesicular transport. They act as molecular switches that convert between GTP-bound and GDP-bound states, and regulate virtually all steps of membrane traffic from the formation of the transport vesicle at the donor membrane to its fusion at the target membrane. In the GDP-bound state, Ypt proteins are predominantly cytosolic, solubilized through the interaction with a GDP dissociation inhibitor (GDI). In the GTP-bound state, the proteins are membrane bound and interact with specific effector proteins that select cargo, promote vesicle movement, or verify the correct site of fusion (By similarity).
Ypt7 is necessary for trafficking from the endosome to the vacuole and for homotypic vacuole fusion (PubMed:19453973, PubMed:9443913).
Plays an important role in sporulation (PubMed:16357443).
Ypt7 is necessary for trafficking from the endosome to the vacuole and for homotypic vacuole fusion (PubMed:19453973, PubMed:9443913).
Plays an important role in sporulation (PubMed:16357443).
Activity regulation
Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 17-23 | GTP (UniProtKB | ChEBI) | |||
Binding site | 33-40 | GTP (UniProtKB | ChEBI) | |||
Binding site | 66 | GTP (UniProtKB | ChEBI) | |||
Binding site | 125-128 | GTP (UniProtKB | ChEBI) | |||
Binding site | 157-159 | GTP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | fungal-type vacuole membrane | |
Cellular Component | late endosome | |
Cellular Component | vacuolar membrane | |
Cellular Component | vacuole | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Biological Process | endocytosis | |
Biological Process | Golgi to vacuole transport | |
Biological Process | intracellular protein transport | |
Biological Process | positive regulation of vacuole fusion, non-autophagic | |
Biological Process | regulation of vacuole fusion, non-autophagic | |
Biological Process | signaling | |
Biological Process | vacuole fusion, non-autophagic |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameYpt/Rab-type GTPase ypt7
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Taphrinomycotina > Schizosaccharomycetes > Schizosaccharomycetales > Schizosaccharomycetaceae > Schizosaccharomyces
Accessions
- Primary accessionO94655
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Asci produce less than 4 spores, which are immature and germinate at low frequency. Cells are defective in development of the forespore membranes.
PTM/Processing
Features
Showing features for chain, lipidation, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000121313 | 1-205 | Ypt/Rab-type GTPase ypt7 | ||
Lipidation | 203 | S-geranylgeranyl cysteine | |||
Modified residue | 205 | Cysteine methyl ester | |||
Lipidation | 205 | S-geranylgeranyl cysteine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Motif | 37-45 | Effector region | |||
Sequence similarities
Belongs to the small GTPase superfamily. Rab family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length205
- Mass (Da)22,994
- Last updated1999-05-01 v1
- ChecksumB63D9B5A019FBA32
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU329671 EMBL· GenBank· DDBJ | CAB38603.1 EMBL· GenBank· DDBJ | Genomic DNA |