O94655 · YPT7_SCHPO

Function

function

Ypt/Rab-type GTPases are key regulators of membrane trafficking and intracellular vesicular transport. They act as molecular switches that convert between GTP-bound and GDP-bound states, and regulate virtually all steps of membrane traffic from the formation of the transport vesicle at the donor membrane to its fusion at the target membrane. In the GDP-bound state, Ypt proteins are predominantly cytosolic, solubilized through the interaction with a GDP dissociation inhibitor (GDI). In the GTP-bound state, the proteins are membrane bound and interact with specific effector proteins that select cargo, promote vesicle movement, or verify the correct site of fusion (By similarity).
Ypt7 is necessary for trafficking from the endosome to the vacuole and for homotypic vacuole fusion (PubMed:19453973, PubMed:9443913).
Plays an important role in sporulation (PubMed:16357443).

Activity regulation

Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).

Features

Showing features for binding site.

120520406080100120140160180200
TypeIDPosition(s)Description
Binding site17-23GTP (UniProtKB | ChEBI)
Binding site33-40GTP (UniProtKB | ChEBI)
Binding site66GTP (UniProtKB | ChEBI)
Binding site125-128GTP (UniProtKB | ChEBI)
Binding site157-159GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentfungal-type vacuole membrane
Cellular Componentlate endosome
Cellular Componentvacuolar membrane
Cellular Componentvacuole
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological Processendocytosis
Biological ProcessGolgi to vacuole transport
Biological Processintracellular protein transport
Biological Processpositive regulation of vacuole fusion, non-autophagic
Biological Processregulation of vacuole fusion, non-autophagic
Biological Processsignaling
Biological Processvacuole fusion, non-autophagic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ypt/Rab-type GTPase ypt7

Gene names

    • Name
      ypt7
    • ORF names
      SPBC405.04c

Organism names

Accessions

  • Primary accession
    O94655

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Asci produce less than 4 spores, which are immature and germinate at low frequency. Cells are defective in development of the forespore membranes.

PTM/Processing

Features

Showing features for chain, lipidation, modified residue.

Type
IDPosition(s)Description
ChainPRO_00001213131-205Ypt/Rab-type GTPase ypt7
Lipidation203S-geranylgeranyl cysteine
Modified residue205Cysteine methyl ester
Lipidation205S-geranylgeranyl cysteine

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif37-45Effector region

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    205
  • Mass (Da)
    22,994
  • Last updated
    1999-05-01 v1
  • Checksum
    B63D9B5A019FBA32
MAGKKKHLLKVIILGESGVGKTSIMNQYVNRKFSKDYKATIGADFLTKEVLVDDKVVTLQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNSKSFETLDSWRDEFLIQASPSNPETFPFILLGNKVDVEEQKRMVSKSKALAFCQARGEIPYFETSAKEAINVQEAFETVAKLALENMDSDDIAADFTDPIHLDMESQKTSCYC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU329671
EMBL· GenBank· DDBJ
CAB38603.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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