O93428 · CATD_CHIHA

Function

function

Acid protease active in intracellular protein breakdown.

Catalytic activity

  • Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
    EC:3.4.23.5 (UniProtKB | ENZYME | Rhea)

Activity regulation

Inhibited by pepstatin.

pH Dependence

Optimum pH is 3.0.

Temperature Dependence

Highly thermostable. Enzyme activity is maintained up to 45 degrees Celsius. Active at 50 degrees Celsius but with reduced catalytic activity.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site94
Active site281

GO annotations

AspectTerm
Cellular Componentlysosome
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

Gene names

    • Name
      ctsd

Organism names

Accessions

  • Primary accession
    O93428

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-18
PropeptidePRO_000028598419-61Activation peptide
ChainPRO_500006448162-396Cathepsin D
Disulfide bond107↔114
Glycosylation131N-linked (GlcNAc...) asparagine
Glycosylation249N-linked (GlcNAc...) asparagine
Disulfide bond272↔276
Disulfide bond315↔352

Keywords

PTM databases

Interaction

Subunit

Monomer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain76-393Peptidase A1

Sequence similarities

Belongs to the peptidase A1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    396
  • Mass (Da)
    42,958
  • Last updated
    2007-05-01 v2
  • Checksum
    B660E5E7FBD023FF
MKMLLLCVFSALALTNDALVRIPLKKFRSIRRQLTDSGKRAEELLADHHSLKYNLSFPASNAPTPETLKNYLDAQYYGEIGLGTPPQPFTVVFDTGSSNLWVPSIHCSLLDIACLLHHKYNSGKSSTYVKNGTAFAIQYGSGSLSGYLSQDTCTIGDLAIDSQLFGEAIKQPGVAFIAAKFDGILGMAYPRISVDGVAPVFDNIMSQKKVEQNVFSFYLNRNPDTEPGGELLLGGTDPKYYTGDFNYVNVTRQAYWQIRVDSMAVGDQLSLCTGGCEAIVDSGTSLITGPSVEVKALQKAIGAFPLIQGEYMVNCDTVPSLPVISFTVGGQVYTLTGEQYILKVTQAGKTMCLSGFMGLDIPAPAGPLWILGDVFMGQYYTVFDRDANRVGFAKAK

Sequence caution

The sequence CAA07719.1 differs from that shown. Reason: Frameshift

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ007878
EMBL· GenBank· DDBJ
CAA07719.1
EMBL· GenBank· DDBJ
mRNA Frameshift

Similar Proteins

Disclaimer

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