O89252 · O89252_9FLAV

  • Protein
    Genome polyprotein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Organism
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    5/5

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell endoplasmic reticulum membrane
Cellular Componenthost cell mitochondrion
Cellular Componenthost cell nucleus
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentmembrane
Cellular Componentviral capsid
Molecular Functionchannel activity
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type endopeptidase activity
Molecular Functionzinc ion binding
Biological Processfusion of virus membrane with host endosome membrane
Biological Processinduction by virus of host autophagy
Biological Processmonoatomic ion transmembrane transport
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processtransformation of host cell by virus
Biological Processviral RNA genome replication
Biological Processvirion attachment to host cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
    GB virus C
  • Strain
    • HGV-BL230
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Pegivirus > Pegivirus hominis

Accessions

  • Primary accession
    O89252

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Multi-pass membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host mitochondrion
Host nucleus
Membrane
; Multi-pass membrane protein
Membrane
; Peripheral membrane protein
Mitochondrion
Virion

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane165-185Helical
Transmembrane548-575Helical
Transmembrane595-622Helical
Transmembrane634-653Helical
Transmembrane673-693Helical
Transmembrane750-772Helical
Transmembrane1525-1548Helical
Transmembrane1709-1736Helical
Transmembrane1742-1764Helical
Transmembrane1776-1800Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain769-894Peptidase C18
Domain894-1074Peptidase S29
Domain1081-1237Helicase ATP-binding
Region2144-2167Disordered
Domain2487-2601RdRp catalytic

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,842
  • Mass (Da)
    307,204
  • Last updated
    1998-11-01 v1
  • Checksum
    1BDF7D4E58AFA911
MAVLLLLFVVEAGAILAPATHACGANGQYFLTNCCALEDIGFCLEGGCLVALGCTVCTDQCWPLYQAGLAVRPSKSAAQLVGELGSLYGPLSVSAYVAGILGLGEVYSGVLTIGVALTRRVYPVPNLTCTVECELKWESEFWRWTEQLASNYWILEYLWKVPFDFWRGVMSLTPLLVCVAALLLLEQRIVMVFLLVTMAGMSQGAPASVMGSRPFDYGLTWQSCSCRSNGSRVPTGEKVWDRGNVTLLCDCPNGPWVWLPAFCQAIGWGEPVTHWSHGQNRWPLSCPQYVYGSVSVTCVWGSVSRFASTGGRDSKIDVWSLVPVGSASCTIAALGSSDRDTVVELSEWGVPCVTCILDRRPASCGTCVRDCWPETGSVRFPFHRCGAGPRLTKDLEAVPFVNRTTPFTIRGPLGNQGRGNPVRSPLGFGSYTMTKIRDSLHLVKCPTPAIEPPTGTFGFFPGVPPLNNCMLLGTEVSEALGGAGLTGGFYEPLVRRCSELMGRRNPVCPGYAWLSSGRPDGFIHVQGHLQEVDAGNFIPPPRWLLLDFVFVLLYLMKLAEARLVPLILLLLWWWVNQLAVLGLPAVDAAVAGEVFAGPALSWCLGLPTVSMILGLANLVLYFRWMGPQRLMFLVLWKLARGAFPLALLMGISATRGRTSVLGAEFCFDVTFEVDTSVLGWVVASVVAWAIAILRSMSAGGWRHKAVIYRTWCRGYQAVRQRVVRSPLGEGRPTKPLTFAWCLASYIWPDAVMMVVVALVLLFGLFDALDWALEELLVSRPSLRRLARVVECCVMAGERATTVRLVSKMCARGAYLFDHMGSFSRAVKERLLEWDAALEPLSFTRTDCRIIRDAARTLSCGQCVMGLPVVARRGDEVLIGVFQDVNHLPPGFVPTAPVVIRRCGKGFLGVTKAALTGRDPDLHPGNVMVLGTATSRSMGTCLNGLLFTTFHGASSRTIATPVGALNPRWWSASDDVTVYPPPMGATSLTPATCQAESLLVIRSDGPLCHGLGKGDKVELDVAMEVADFRGSSGSPVLCDEGHAVGMLVSVLHSGGRVTAARFTRPWTQVPTDAKTTTEPPPVPAKGVFKEAPLFMPTGAGKSTRVPLEYGNMGHKVLILNPSVATVRAMGPYMERLAGKHPSIYCGHDTTAFTRITDSPLTYSTYGRFLANPRQMLRGVPVVICDECHSHDSTVLLGIGRVRELARGCGVQLVLYATATPPGSPMTQHPSIIETNLTLGEIPFYGHGIPLERMRTGRHLVFCHSKAECERLAGQFSARGVNAIAYYRGKDSSIIKDGDLVVCATDALSTGYTGNFDSVTDCGLVVEEVVEVTLDPTITISLRTVPASAELSMQRRGRTGRGRSGRYYYAGVGKAPAGVVRSGPVWSAVEAGVTWYGMEPDLTANLLRLYDDCPYTAAVAADIGEAAVFFAGLAPLRMHPDVSWAKVRGVNWPLLVGVQRTMCRETLSPGPSDDPQWAGLKGPNPVPLLLRWGNDLPSKVAGHHIVDDLVRRLGVAEGYVRCDAGPILMVGLAIAGGMIYASYTGSLVVVTDWDVKGGGAPLYRHGDQATPQPVVQVPPVDHRPGGEAAPADAKTVTDAVAAIQVDCDWSVMTLSIGEVLSLAQAKTAEAYTATAKWLAGCYTGTRAVPTVSIVDKLFAGGWAAVVGHCHSVIAAAVAAYGASRSPPLAAAASYLMGLGVGGNAQARLASALLLGAAGTALGTPVVGLTMAGAFMGGASVSPSLVTVLLGAVGGWEGVVNAASLVFDFMAGKLSTEDLWYAIPVLTSPGAGLAGIALGLVLYSANNSGTTTWLNRLLTTLPRSSCIPDSYFQQADYCDKVSAMLRRLSLTRTVVALVNREPKVDEVQVGYVWDLWEWIMRQVRMVVSRLRALCPVVSLPLWHCGEGWSGEWLLDGHVESRCLCGCVITGDVFNGQLKDPVYSTKLCRHYWMGTVPVNMLGYGETSPLLASDTPKVVPFGTSGWAEVVVTPTHVVVRRTSSYKLLRQQILSAAVAEPYYVDGIPVSWEADARAPAMVYGAGQSVTIDGERYTLPHQLRMRNVAPSEVSSEVSIEIGTETEDSELTEADLPPAAAALQAIENAARILEPHIDVIMEDCSTPSLCGSSREMPVWGEDIPRTPSPALISVTESGSGEFTPSVSSSQEDTPSSDSFEVIQESDTAESEENVFNVALSVLKALFPQSDATRKLTVKMSCCVEKSVTRFFSLGLTVADVASLCEMEIQNHTAYCDKVRTPLELQVGCLVGNELTFECDKCEARQETLASFSYIWSGVPLTRATPAKPPVVRPVGSLLVADTTKVYVTNPDNVGRRVDKVTFWRAPRVHDKYLVDSTERARRAAQACLSMGYTYEEAIRTVRPHAAMGWGSKVSVKDLATPAGKMAVHDRLQEILEGTPVPFTLTVKREVFFKDRKEEKAPRLIVFPPLDFRIAEKLILGDPGKVAKAVLGGAYAFQYTPNQRVKEMLRLWESKKTPCAICVDATCFDSSITEEDVALETELYALASDHPEWVRALGKYYASGTMVTPEGVPVGERYCRSSGVLTTSASNCLTCYIKVKAACDRVGLKNVSLLIAGDDCLIICERPMCDPSEALGRALASYGYACEPSYHASLDTAPFCSTWLAECNADGKRHFFLTTDFRRPLARMSSEYSDPMASAIGYILLYPWHPITRWVIIPHVLTCAFRGGGTPSDPVWCQVHGNYYKFPLDKLPNIIVALHGPAALRVTADTTKTKMEAGKVLSDLRLPGLAVHRKKAGALRTRMLRSRGWAELARGLLWHPGLRLPPPEIAGIPGGFPLSPPYMGVVHQLDFTAQRSRWRWLGFLALLIVALFG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB013501
EMBL· GenBank· DDBJ
BAA32206.1
EMBL· GenBank· DDBJ
Genomic RNA

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