O89023 · TPP1_MOUSE
- ProteinTripeptidyl-peptidase 1
- GeneTpp1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids562 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for O89023
Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.
- CategoriesSequences
- SourceMGI: 1336194
Neuronal ceroid lipofuscinosis genes, CLN2, CLN3 and CLN5 are spatially and temporally co-expressed in a developing mouse brain.
- AnnotationRssults suggested that CLN2 CLN3 and CLN5 genes may play an important role in early embryonal neurogenesis.
- CategoriesSequences, Expression
Developmental study of tripeptidyl peptidase I activity in the mouse central nervous system and peripheral organs.
- AnnotationTPPI activity becomes crucial for the neuronal functions later in development.
- CategoriesSequences
- SourceGeneRif: 12751
Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis.
- AnnotationResults indicate that the loss of TPPI cannot be functionally compensated for by DPPI.
- CategoriesSequences, Phenotypes & Variants
Residual levels of tripeptidyl-peptidase I activity dramatically ameliorate disease in late-infantile neuronal ceroid lipofuscinosis.
- AnnotationExpression of 6% of normal TPPI activity increased lifespan to that of unaffected mice.
- CategoriesSequences, Phenotypes & Variants
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
- CategoriesSequences
- SourceMGI: 1336194
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
- CategoriesSequences
- SourceMGI: 1336194
Lysosomal degradation of cholecystokinin-(29-33)-amide in mouse brain is dependent on tripeptidyl peptidase-I: implications for the degradation and storage of peptides in classical late-infantile neuronal ceroid lipofuscinosis.
- AnnotationLysosomal degradation of cholecystokinin-(29-33)-amide in mouse brain is dependent on this enzyme: implications for the degradation and storage of peptides in classical late-infantile neuronal ceroid lipofuscinosis (tripeptidyl peptidase-I)
- CategoriesSequences, Subcellular Location, Function
Functional annotation of a full-length mouse cDNA collection.
- CategoriesSequences
- SourceMGI: 1336194