ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization.Cases S., Novak S., Zheng Y.-W., Myers H.M., Lear S.R., Sande E., Welch C.B., Lusis A.J., Spencer T.A.[...], Farese R.V. Jr.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]StrainC57BL/6JCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 273:26755-26764 (1998)Cited in1Mapped to34
No title available.Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (SEP-2005)Cited in99+12
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]StrainFVB/NTissueLiverCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane.Joyce C.W., Shelness G.S., Davis M.A., Lee R.G., Skinner K., Anderson R.A., Rudel L.L.View abstractCited forTOPOLOGY, SUBCELLULAR LOCATIONCategoriesSubcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Biol. Cell 11:3675-3687 (2000)Cited in2
A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueLiverCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 143:1174-1189 (2010)Cited in99+99+Mapped to6
Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.Wang Y.J., Bian Y., Luo J., Lu M., Xiong Y., Guo S.Y., Yin H.Y., Lin X., Li Q.[...], Song B.L.View abstractCited forDISRUPTION PHENOTYPECategoriesPhenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Cell Biol. 19:808-819 (2017)Cited in4Mapped to5
Corrigendum: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.Wang Y.J., Bian Y., Luo J., Lu M., Xiong Y., Guo S.Y., Yong H., Lin X., Li Q.[...], Song B.L.View abstractCited forERRATUM OF PUBMED:28604676SourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Cell Biol. 19:1441-1441 (2017)Cited in4
Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under- representation on the X chromosome.Ko M.S., Threat T.A., Wang X., Horton J.H., Cui Y., Wang X., Pryor E., Paris J., Wells-Smith J.[...], Nakashima H.View abstractCategoriesSequencesSourceMGI: 1332226PubMedEurope PMCHum Mol Genet 7:1967-1978 (1998)Mapped to99+
The gene encoding PRBP, the mouse homolog of human TRBP, maps to distal chromosome 15.Zhong J., Edelhoff S., Disteche C., Braun R.E.CategoriesSequencesSourceMGI: 1332226PubMedEurope PMCMamm Genome 9:413-414 (1998)Mapped to19
Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.Yang W., Bai Y., Xiong Y., Zhang J., Chen S., Zheng X., Meng X., Li L., Wang J.[...], Xu C.View abstractCategoriesFunctionSourceMGI: 1332226PubMedEurope PMCNature 531:651-655 (2016)Mapped to7
Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver.Lopez A.M., Posey K.S., Turley S.D.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1332226PubMedEurope PMCBiochem Biophys Res Commun 454:162-166 (2014)Mapped to5
Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2.Zhang J., Sawyer J.K., Marshall S.M., Kelley K.L., Davis M.A., Wilson M.D., Brown J.M., Rudel L.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1332226PubMedEurope PMCCirc Res 115:826-833 (2014)Mapped to10
Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs.Iqbal J., Boutjdir M., Rudel L.L., Hussain M.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1332226PubMedEurope PMCJ Lipid Res 55:2261-2275 (2014)Mapped to7
Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice.Pedrelli M., Davoodpour P., Degirolamo C., Gomaraschi M., Graham M., Ossoli A., Larsson L., Calabresi L., Gustafsson J.A.[...], Parini P.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1332226PubMedEurope PMCPLoS One 9:e93552-e93552 (2014)Mapped to15
LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.Melchior J.T., Sawyer J.K., Kelley K.L., Shah R., Wilson M.D., Hantgan R.R., Rudel L.L.View abstractCategoriesFunctionSourceMGI: 1332226PubMedEurope PMCJ Lipid Res 54:2495-2503 (2013)Mapped to14
Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine.Xie 谢畅 C., Zhou 周章森 Z.S., Li 李钠 N., Bian 卞艳 Y., Wang 王永建 Y.J., Wang 王丽娟 L.J., Li 李伯良 B.L., Song 宋保亮 B.L.View abstractCategoriesSubcellular LocationSourceMGI: 1332226PubMedEurope PMCJ Lipid Res 53:2092-2101 (2012)Mapped to7
ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation.Nguyen T.M., Sawyer J.K., Kelley K.L., Davis M.A., Kent C.R., Rudel L.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1332226PubMedEurope PMCJ Lipid Res 53:1598-1609 (2012)Mapped to17
Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase.Rogers M.A., Liu J., Kushnir M.M., Bryleva E., Rockwood A.L., Meikle A.W., Shapiro D., Vaisman B.L., Remaley A.T.[...], Chang T.Y.View abstractCategoriesFunctionSourceMGI: 1332226PubMedEurope PMCJ Biol Chem 287:17483-17492 (2012)Mapped to11
Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.Zhang J., Kelley K.L., Marshall S.M., Davis M.A., Wilson M.D., Sawyer J.K., Farese R.V. Jr., Brown J.M., Rudel L.L.View abstractCategoriesPhenotypes & VariantsSourceMGI: 1332226PubMedEurope PMCJ Lipid Res 53:1144-1152 (2012)Mapped to2
Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation.Nguyen T.M., Sawyer J.K., Kelley K.L., Davis M.A., Rudel L.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1332226PubMedEurope PMCJ Lipid Res 53:95-104 (2012)Mapped to5
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.Diez-Roux G., Banfi S., Sultan M., Geffers L., Anand S., Rozado D., Magen A., Canidio E., Pagani M.[...], Ballabio A.View abstractCategoriesExpressionSourceMGI: 1332226PubMedEurope PMCPLoS Biol 9:e1000582-e1000582 (2011)Mapped to99+
Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.Turley S.D., Valasek M.A., Repa J.J., Dietschy J.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1332226PubMedEurope PMCAm J Physiol Gastrointest Liver Physiol 299:G1012-22 (2010)Mapped to4
Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.Alger H.M., Brown J.M., Sawyer J.K., Kelley K.L., Shah R., Wilson M.D., Willingham M.C., Rudel L.L.View abstractCategoriesFunctionSourceMGI: 1332226PubMedEurope PMCJ Biol Chem 285:14267-14274 (2010)Mapped to14
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.Bryleva E.Y., Rogers M.A., Chang C.C., Buen F., Harris B.T., Rousselet E., Seidah N.G., Oddo S., LaFerla F.M.[...], Chang T.Y.View abstractCategoriesFunctionSourceMGI: 1332226PubMedEurope PMCProc Natl Acad Sci U S A 107:3081-3086 (2010)Mapped to12
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.Hansen G.M., Markesich D.C., Burnett M.B., Zhu Q., Dionne K.M., Richter L.J., Finnell R.H., Sands A.T., Zambrowicz B.P., Abuin A.View abstractCategoriesSequencesSourceMGI: 1332226PubMedEurope PMCGenome Res 18:1670-1679 (2008)Mapped to99+