O88898 · P63_MOUSE

  • Protein
    Tumor protein 63
  • Gene
    Tp63
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity).
Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for dna binding, binding site.

168050100150200250300350400450500550600650
TypeIDPosition(s)Description
DNA binding170-362
Binding site244Zn2+ (UniProtKB | ChEBI)
Binding site247Zn2+ (UniProtKB | ChEBI)
Binding site308Zn2+ (UniProtKB | ChEBI)
Binding site312Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromatin
Cellular Componentcytoplasm
Cellular Componentdendrite
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentprotein-containing complex
Molecular Functionchromatin binding
Molecular Functiondamaged DNA binding
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functiondouble-stranded DNA binding
Molecular Functionidentical protein binding
Molecular FunctionMDM2/MDM4 family protein binding
Molecular Functionmetal ion binding
Molecular Functionp53 binding
Molecular Functionpromoter-specific chromatin binding
Molecular Functionprotein domain specific binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionsequence-specific DNA binding
Molecular FunctionWW domain binding
Biological Processanatomical structure formation involved in morphogenesis
Biological Processanimal organ morphogenesis
Biological Processapoptotic process
Biological Processcellular senescence
Biological Processchromatin remodeling
Biological Processcloacal septation
Biological Processcranial skeletal system development
Biological Processdetermination of adult lifespan
Biological Processectoderm and mesoderm interaction
Biological Processembryonic forelimb morphogenesis
Biological Processembryonic hindlimb morphogenesis
Biological Processembryonic limb morphogenesis
Biological Processepidermal cell differentiation
Biological Processepidermal cell division
Biological Processepidermis development
Biological Processepithelial cell development
Biological Processepithelial cell differentiation
Biological Processestablishment of planar polarity
Biological Processestablishment of skin barrier
Biological Processfemale genitalia morphogenesis
Biological Processhair follicle development
Biological Processhair follicle morphogenesis
Biological Processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Processkeratinocyte differentiation
Biological Processkeratinocyte proliferation
Biological Processmorphogenesis of a polarized epithelium
Biological Processnegative regulation of intracellular estrogen receptor signaling pathway
Biological Processnegative regulation of keratinocyte differentiation
Biological Processnegative regulation of mesoderm development
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processneuron apoptotic process
Biological ProcessNotch signaling pathway
Biological Processodontogenesis of dentin-containing tooth
Biological Processpattern specification process
Biological Processpolarized epithelial cell differentiation
Biological Processpositive regulation of apoptotic signaling pathway
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of fibroblast apoptotic process
Biological Processpositive regulation of keratinocyte proliferation
Biological Processpositive regulation of Notch signaling pathway
Biological Processpositive regulation of osteoblast differentiation
Biological Processpositive regulation of somatic stem cell population maintenance
Biological Processpositive regulation of stem cell proliferation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpost-anal tail morphogenesis
Biological Processprostate gland development
Biological Processprostatic bud formation
Biological Processprotein tetramerization
Biological Processproximal/distal pattern formation
Biological Processregulation of epidermal cell division
Biological Processregulation of transcription by RNA polymerase II
Biological Processskeletal system development
Biological Processskin epidermis development
Biological Processskin morphogenesis
Biological Processspermatogenesis
Biological Processsquamous basal epithelial stem cell differentiation involved in prostate gland acinus development
Biological Processstem cell differentiation
Biological Processstem cell proliferation
Biological Processsympathetic nervous system development
Biological Processtranscription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tumor protein 63
  • Short names
    p63
  • Alternative names
    • Transformation-related protein 63 (TP63)
    • Tumor protein p73-like (p73L)

Gene names

    • Name
      Tp63
    • Synonyms
      P63, P73l, Tp73l, Trp63

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O88898
  • Secondary accessions
    • O88897
    • O88899
    • O89097
    • Q8C826
    • Q9QWY9
    • Q9QWZ0

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis543Abolishes interaction with WWP1.
Mutagenesis647Heterozygous mutant mice have reduced fertility, reduced ovary size and accelerated oocyte loss via apoptosis.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 28 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00001857301-680Tumor protein 63
Cross-link676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modification

May be sumoylated.
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed, notably in thymus, prostate, placenta and skeletal muscle, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast and prostate express high levels of DeltaN-type isoforms.

Induction

Induced by DNA damaging agents.

Developmental stage

Expressed in the basal layer and a small number of cells in the spinous layer of the tongue at P20.

Isoform 1

Expressed in the epidermis from 7.5 dpc, prior to onset of epithelial stratification.

Isoform 2

Expressed in the epidermis from 9.5 dpc, after the onset of epithelial stratification but prior to terminal differentiation.

Isoform 3

Expressed in the epidermis from 7.5 dpc, prior to onset of epithelial stratification.

Isoform 4

Expressed in the epidermis from 9.5 dpc, after the onset of epithelial stratification but prior to terminal differentiation.

Isoform 5

Expressed in the epidermis from 7.5 dpc, prior to onset of epithelial stratification.

Isoform 6

Expressed in the epidermis from 9.5 dpc, after the onset of epithelial stratification but prior to terminal differentiation.

Gene expression databases

Interaction

Subunit

Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Interacts with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Interacts with PDS5A. Interacts (via activation domain) with NOC2L (By similarity).
Interacts with WWP1

Binary interactions

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-107Transcription activation
Compositional bias123-166Polar residues
Region123-171Disordered
Region351-393Disordered
Region352-388Interaction with HIPK2
Compositional bias364-389Polar residues
Region394-443Oligomerization
Region436-472Disordered
Domain541-607SAM
Region610-680Transactivation inhibition

Domain

The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms.

Sequence similarities

Belongs to the p53 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (6)
  • Sequence status
    Complete

This entry describes 6 isoforms produced by Alternative promoter usage & Alternative splicing.

O88898-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    TA*-alpha, TA*p63alpha
  • Note
    Produced by alternative promoter usage.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    680
  • Mass (Da)
    76,789
  • Last updated
    1998-11-01 v1
  • Checksum
    8DFF0284F247C68A
MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE

O88898-2

  • Name
    2
  • Synonyms
    DeltaN-alpha
  • Note
    Produced by alternative promoter usage.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-108: MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMW → MLYLENNAQTQFSE

O88898-3

  • Name
    3
  • Synonyms
    TA*-beta, TA*p63beta
  • Note
    Produced by alternative splicing of isoform 1.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 551-680: SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE → RIWQV

O88898-4

  • Name
    4
  • Synonyms
    DeltaN-beta
  • Note
    Produced by alternative splicing of isoform 2.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-108: MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMW → MLYLENNAQTQFSE
    • 551-680: SFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE → RIWQV

O88898-5

  • Name
    5
  • Synonyms
    TA*-gamma, TA*p63gamma
  • Note
    Produced by alternative splicing of isoform 1.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 373-377: GTKRP → A
    • 450-680: QTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE → HLLSACFRNELVEPRGEAPTQSDVFFRHSNPPNHSVYP

O88898-6

  • Name
    6
  • Synonyms
    DeltaN-gamma
  • Note
    Produced by alternative splicing of isoform 2.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-108: MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMW → MLYLENNAQTQFSE
    • 373-377: GTKRP → A
    • 450-680: QTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE → HLLSACFRNELVEPRGEAPTQSDVFFRHSNPPNHSVYP

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0R4J1K8A0A0R4J1K8_MOUSETrp63284
Q569E5Q569E5_MOUSETrp63393
D3Z7K2D3Z7K2_MOUSETrp63231
Q3UVI3Q3UVI3_MOUSETrp63582

Sequence caution

The sequence BAC33397.1 differs from that shown. Reason: Miscellaneous discrepancy Intron retention.

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0124711-108in isoform 2, isoform 4 and isoform 6
Compositional bias123-166Polar residues
Compositional bias364-389Polar residues
Alternative sequenceVSP_012472373-377in isoform 5 and isoform 6
Alternative sequenceVSP_012473450-680in isoform 5 and isoform 6
Alternative sequenceVSP_012474551-680in isoform 3 and isoform 4

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF075434
EMBL· GenBank· DDBJ
AAC62639.1
EMBL· GenBank· DDBJ
mRNA
AF075435
EMBL· GenBank· DDBJ
AAC62640.1
EMBL· GenBank· DDBJ
mRNA
AF075436
EMBL· GenBank· DDBJ
AAC62641.1
EMBL· GenBank· DDBJ
mRNA
AF075437
EMBL· GenBank· DDBJ
AAC62642.1
EMBL· GenBank· DDBJ
mRNA
AF075438
EMBL· GenBank· DDBJ
AAC62643.1
EMBL· GenBank· DDBJ
mRNA
AF075439
EMBL· GenBank· DDBJ
AAC62644.1
EMBL· GenBank· DDBJ
mRNA
AB010152
EMBL· GenBank· DDBJ
BAA32432.1
EMBL· GenBank· DDBJ
mRNA
AF533892
EMBL· GenBank· DDBJ
AAP87982.1
EMBL· GenBank· DDBJ
Genomic DNA
AF533892
EMBL· GenBank· DDBJ
AAP87985.1
EMBL· GenBank· DDBJ
Genomic DNA
AF533892
EMBL· GenBank· DDBJ
AAP87983.1
EMBL· GenBank· DDBJ
Genomic DNA
AF533892
EMBL· GenBank· DDBJ
AAP87984.1
EMBL· GenBank· DDBJ
Genomic DNA
AF533892
EMBL· GenBank· DDBJ
AAP87986.1
EMBL· GenBank· DDBJ
Genomic DNA
AF533892
EMBL· GenBank· DDBJ
AAP87987.1
EMBL· GenBank· DDBJ
Genomic DNA
AK048623
EMBL· GenBank· DDBJ
BAC33397.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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