O88881 · BEGIN_RAT

  • Protein
    Brain-enriched guanylate kinase-associated protein
  • Gene
    Begain
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May sustain the structure of the postsynaptic density (PSD).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentdendrite
Cellular Componentglutamatergic synapse
Cellular Componentmembrane
Cellular Componentneuronal cell body
Cellular Componentnucleus
Cellular Componentpostsynapse
Cellular Componentpresynapse
Cellular Componentsynapse
Biological Processevoked excitatory postsynaptic potential

Names & Taxonomy

Protein names

  • Recommended name
    Brain-enriched guanylate kinase-associated protein

Gene names

    • Name
      Begain

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    O88881
  • Secondary accessions
    • O88882

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000649061-611Brain-enriched guanylate kinase-associated protein
Modified residue156Phosphotyrosine
Modified residue219Phosphoserine
Modified residue248Phosphoserine
Modified residue265Phosphoserine
Modified residue268Phosphothreonine
Modified residue284Phosphoserine
Modified residue364Phosphoserine
Modified residue391Phosphoserine
Modified residue399Asymmetric dimethylarginine
Modified residue474Phosphoserine
Modified residue484Phosphoserine
Modified residue494Phosphoserine
Modified residue496Phosphoserine
Modified residue519Phosphoserine
Modified residue521Phosphoserine
Modified residue525Phosphoserine
Modified residue571Phosphoserine
Modified residue581Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Brain-specific. Expressed in neurons and rather enriched at synaptic junctions.

Gene expression databases

Interaction

Subunit

Interacts with DLG4 and DLGAP1 and forms a ternary complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region520-611Disordered
Compositional bias582-611Polar residues

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

O88881-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    BEGAIN-2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    611
  • Mass (Da)
    66,993
  • Last updated
    1998-11-01 v1
  • Checksum
    1AA06C6389DDFFCF
MWTGGRRPGRLRRAASAADMEKLSALQEQKGELRKRLSYTTHKLEKLETEFDSTRHYLEIELRRAQEELDKVTEKLRRIQSNYMALQRINQELEDKLYRMGQHYEEEKRAMSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCNLAAQLLQCSQTYGRVHKVSELPSDFQQRVSLHMEKHGCSLPSPLCHPSYADSVPTCVIAKVLEKPDPGSLSSRMSDASARDLAYRDGVENPGPRPPYKGDIYCSDTALYCPDERDHDRRPSVDTPVTDVGFLRAQNSTDSLAEEEEAEAAAFPEAYRREAFQGYAASLPTSSSYSSFSATSEEKEHAQASTLTASQQAIYLNSREELFSRKPPSATYGSSPRYAKAAATLGSPLEAQVAPGFARTVSPYPAEPYRYPASQQALMPPNLWSLRAKPSGNRLAAREDIRGQWRPLSVEDVGAYSYQAGAAGRAASPCNFSERFYGGGGGGGSPGKNAEGRASPLYASYKADSFSEGDDLSQGHLAEPCFLRAGGDLSLSPSRSADPLPGYATSDGDGDRLGVQLCGPGSSPEPEHGSRDSLEPSSMEASPEMHPPTRLSPQQAFPRTGGSGLSRKDSLTKAQLYGTLLN

O88881-2

  • Name
    2
  • Synonyms
    BEGAIN-1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-14: MWTGGRRPGRLRRA → MGSDQSSQ

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0G2K0E5A0A0G2K0E5_RATBegain611
A0A8I6AA22A0A8I6AA22_RATBegain804
A0A8I6GDW4A0A8I6GDW4_RATBegain605

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0125841-14in isoform 2
Compositional bias582-611Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF064868
EMBL· GenBank· DDBJ
AAC63267.1
EMBL· GenBank· DDBJ
mRNA
AF064869
EMBL· GenBank· DDBJ
AAC63268.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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