O88848 · ARL6_MOUSE

  • Protein
    ADP-ribosylation factor-like protein 6
  • Gene
    Arl6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in membrane protein trafficking at the base of the ciliary organelle (By similarity).
Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity).
Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (PubMed:24939912).
Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (By similarity).
May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (By similarity).
Isoform 2 may be required for proper retinal function and organization (PubMed:20333246).

Features

Showing features for binding site.

118620406080100120140160180
TypeIDPosition(s)Description
Binding site24-31GTP (UniProtKB | ChEBI)
Binding site50GTP (UniProtKB | ChEBI)
Binding site50Mg2+ (UniProtKB | ChEBI)
Binding site69-73GTP (UniProtKB | ChEBI)
Binding site72GTP (UniProtKB | ChEBI)
Binding site130-133GTP (UniProtKB | ChEBI)
Binding site164GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxonemal microtubule
Cellular Componentaxoneme
Cellular Componentciliary membrane
Cellular Componentcilium
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentmembrane
Cellular Componentmembrane coat
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmetal ion binding
Molecular FunctionNAD+-protein ADP-ribosyltransferase activity
Molecular Functionphospholipid binding
Biological Processbrain development
Biological Processcilium assembly
Biological Processfat cell differentiation
Biological Processintracellular protein transport
Biological Processprotein localization to cilium
Biological Processprotein localization to non-motile cilium
Biological Processprotein polymerization
Biological Processprotein targeting to membrane
Biological Processprotein transport from ciliary membrane to plasma membrane
Biological ProcessRas protein signal transduction
Biological Processregulation of smoothened signaling pathway
Biological Processretina layer formation
Biological Processvesicle-mediated transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-ribosylation factor-like protein 6

Gene names

    • Name
      Arl6
    • Synonyms
      Bbs3

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O88848
  • Secondary accessions
    • Q3TY77

Proteomes

Organism-specific databases

Subcellular Location

Cell projection, cilium membrane
; Peripheral membrane protein
Note: Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane (By similarity).

Keywords

Phenotypes & Variants

Disruption phenotype

Isoform 2 deficient mice present a disruption of the normal photoreceptor architecture.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for initiator methionine, lipidation, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Lipidation2N-myristoyl glycine
ChainPRO_00002074732-186ADP-ribosylation factor-like protein 6

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Most abundant in brain and kidney. Expressed in heart and eye. Isoform 2 is expressed only in the retina.

Gene expression databases

Interaction

Subunit

Interacts with SEC61B, ARL6IP1, ARL6IP2, ARL6IP3, ARL6IP4 ARL6IP5 and ARL6IP6. Interacts (GTP-bound form) with the BBSome a complex that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts (GTP-free form) with IFT27.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

O88848-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    Bbs3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    186
  • Mass (Da)
    20,959
  • Last updated
    1998-11-01 v1
  • Checksum
    4F26947318977386
MGLLDRLSGLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQDIVPTIGFSIEKFKSSSLSFTVFDMSGQGRYRNLWEHYYKDGQAIIFVIDSSDKLRMVVAKEELDTLLNHPDIKHRRIPILFFANKMDLRDSVTSVKVSQLLCLESIKDKPWHICASDAIKGEGLQEGVDWLQDQIQAVKT

O88848-2

  • Name
    2
  • Synonyms
    Bbs3l
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 179-186: DQIQAVKT → EKTVQSDPSCEDVKR

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
D3Z067D3Z067_MOUSEArl6194

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_040512179-186in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF031903
EMBL· GenBank· DDBJ
AAC62194.1
EMBL· GenBank· DDBJ
mRNA
AK158832
EMBL· GenBank· DDBJ
BAE34686.1
EMBL· GenBank· DDBJ
mRNA
AK003778
EMBL· GenBank· DDBJ
BAB22990.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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