O88575 · S620B_MOUSE

  • Protein
    Sodium- and chloride-dependent transporter XTRP3B
  • Gene
    Slc6a20b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Does not show transporter activity with a range of tested amino acids including proline, glutamine, glutamic acid, leucine, alanine, histidine, glycine and arginine.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbrush border membrane
Cellular Componentplasma membrane
Molecular FunctionL-proline transmembrane transporter activity
Molecular Functionproline:sodium symporter activity
Biological Processglycine transport
Biological ProcessL-proline import across plasma membrane
Biological Processsodium ion transmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium- and chloride-dependent transporter XTRP3B
  • Alternative names
    • IMINO-K
    • Solute carrier family 6 member 20B

Gene names

    • Name
      Slc6a20b
    • Synonyms
      Slc6a20, Xt3, Xtrp3

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O88575
  • Secondary accessions
    • E9QNK3
    • Q3TP52
    • Q91WT6

Proteomes

Organism-specific databases

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Note: Located in the apical brush border membrane of kidney proximal tubule cells.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-56Cytoplasmic
Transmembrane57-77Helical; Name=1
Topological domain78-85Extracellular
Transmembrane86-106Helical; Name=2
Topological domain107-127Cytoplasmic
Transmembrane128-148Helical; Name=3
Topological domain149-208Extracellular
Transmembrane209-229Helical; Name=4
Topological domain230-237Cytoplasmic
Transmembrane238-258Helical; Name=5
Topological domain259-284Extracellular
Transmembrane285-305Helical; Name=6
Topological domain306-319Cytoplasmic
Transmembrane320-340Helical; Name=7
Topological domain341-432Extracellular
Transmembrane433-453Helical; Name=8
Topological domain454-474Cytoplasmic
Transmembrane475-495Helical; Name=9
Topological domain496-508Extracellular
Transmembrane509-529Helical; Name=10
Topological domain530-547Cytoplasmic
Transmembrane548-568Helical; Name=11
Topological domain569-597Extracellular
Transmembrane598-618Helical; Name=12
Topological domain619-635Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002148131-635Sodium- and chloride-dependent transporter XTRP3B
Glycosylation174N-linked (GlcNAc...) asparagine
Glycosylation400N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected only in kidney and lung.

Gene expression databases

Interaction

Subunit

Interacts with CLTRN.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-38Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    635
  • Mass (Da)
    70,687
  • Last updated
    2011-07-27 v3
  • Checksum
    465AD54AA807EBE3
MESPSAHAVSLPEDEELQPWGGAGGPGQHPGRPRSTECAHPGVVEKVRPKWDNPLQFLLVCISYAVGLGNVWRFPYLCQMYGGGNFLVPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGIASLVVSFLASVYFNVINTWALWYLFHSFQDPLPWSVCPLNSNHTGYDEECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGKVVYFTTSLPYFVLIIYLVRGLTLHGATNGLAYMFTPKIEQLANPKAWINAATQIFFSLGLGCGGLIAFASYNEPSNDCQKHALIVSVINSTTAIFSSIVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTVSNLEEVKNYLASTYPNKYSEVFPHIRNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLTLGMGSMVGTGTAILTPLTDSKIISSYLPKEAISGLVCLLNCAIGMVFTMEAGNYWFDLFNDYTATLSLLLIVLVETIAVCYVYGLKRFESDLRAMTGRTLSWYWKVMWAFVSPLLIVGLFIFYLSDYILTGTLQYQAWDATQGHVVTKDYPTYALAVIGLLVASSTMCIPLVALGTFVTRHFKIREQFSAA

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F7AVF9F7AVF9_MOUSESlc6a20b84
A0A803YV45A0A803YV45_MOUSESlc6a20b635

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict85in Ref. 1; AAC27756, 2; BAE25668/BAE37885 and 4; AAH13484

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF075261
EMBL· GenBank· DDBJ
AAC27756.1
EMBL· GenBank· DDBJ
mRNA
AK144038
EMBL· GenBank· DDBJ
BAE25668.1
EMBL· GenBank· DDBJ
mRNA
AK164706
EMBL· GenBank· DDBJ
BAE37885.1
EMBL· GenBank· DDBJ
mRNA
AC132852
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC013484
EMBL· GenBank· DDBJ
AAH13484.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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