O88575 · S620B_MOUSE
- ProteinSodium- and chloride-dependent transporter XTRP3B
- GeneSlc6a20b
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids635 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Does not show transporter activity with a range of tested amino acids including proline, glutamine, glutamic acid, leucine, alanine, histidine, glycine and arginine.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | brush border membrane | |
Cellular Component | plasma membrane | |
Molecular Function | L-proline transmembrane transporter activity | |
Molecular Function | proline:sodium symporter activity | |
Biological Process | glycine transport | |
Biological Process | L-proline import across plasma membrane | |
Biological Process | sodium ion transmembrane transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSodium- and chloride-dependent transporter XTRP3B
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO88575
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Note: Located in the apical brush border membrane of kidney proximal tubule cells.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-56 | Cytoplasmic | ||||
Sequence: MESPSAHAVSLPEDEELQPWGGAGGPGQHPGRPRSTECAHPGVVEKVRPKWDNPLQ | ||||||
Transmembrane | 57-77 | Helical; Name=1 | ||||
Sequence: FLLVCISYAVGLGNVWRFPYL | ||||||
Topological domain | 78-85 | Extracellular | ||||
Sequence: CQMYGGGN | ||||||
Transmembrane | 86-106 | Helical; Name=2 | ||||
Sequence: FLVPYIIMLIVEGMPLLYLEL | ||||||
Topological domain | 107-127 | Cytoplasmic | ||||
Sequence: AVGQRMRQGSIGAWRTISPYL | ||||||
Transmembrane | 128-148 | Helical; Name=3 | ||||
Sequence: SGVGIASLVVSFLASVYFNVI | ||||||
Topological domain | 149-208 | Extracellular | ||||
Sequence: NTWALWYLFHSFQDPLPWSVCPLNSNHTGYDEECEKASSTQYFWYRKTLNISPSIQENGG | ||||||
Transmembrane | 209-229 | Helical; Name=4 | ||||
Sequence: VQWEPALCLTLAWLMVYLCIL | ||||||
Topological domain | 230-237 | Cytoplasmic | ||||
Sequence: RGTESTGK | ||||||
Transmembrane | 238-258 | Helical; Name=5 | ||||
Sequence: VVYFTTSLPYFVLIIYLVRGL | ||||||
Topological domain | 259-284 | Extracellular | ||||
Sequence: TLHGATNGLAYMFTPKIEQLANPKAW | ||||||
Transmembrane | 285-305 | Helical; Name=6 | ||||
Sequence: INAATQIFFSLGLGCGGLIAF | ||||||
Topological domain | 306-319 | Cytoplasmic | ||||
Sequence: ASYNEPSNDCQKHA | ||||||
Transmembrane | 320-340 | Helical; Name=7 | ||||
Sequence: LIVSVINSTTAIFSSIVTFSI | ||||||
Topological domain | 341-432 | Extracellular | ||||
Sequence: YGFKATFNYENCLNKVILLLTNSFDLEDGFLTVSNLEEVKNYLASTYPNKYSEVFPHIRNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQ | ||||||
Transmembrane | 433-453 | Helical; Name=8 | ||||
Sequence: LWSVLYFFMLLTLGMGSMVGT | ||||||
Topological domain | 454-474 | Cytoplasmic | ||||
Sequence: GTAILTPLTDSKIISSYLPKE | ||||||
Transmembrane | 475-495 | Helical; Name=9 | ||||
Sequence: AISGLVCLLNCAIGMVFTMEA | ||||||
Topological domain | 496-508 | Extracellular | ||||
Sequence: GNYWFDLFNDYTA | ||||||
Transmembrane | 509-529 | Helical; Name=10 | ||||
Sequence: TLSLLLIVLVETIAVCYVYGL | ||||||
Topological domain | 530-547 | Cytoplasmic | ||||
Sequence: KRFESDLRAMTGRTLSWY | ||||||
Transmembrane | 548-568 | Helical; Name=11 | ||||
Sequence: WKVMWAFVSPLLIVGLFIFYL | ||||||
Topological domain | 569-597 | Extracellular | ||||
Sequence: SDYILTGTLQYQAWDATQGHVVTKDYPTY | ||||||
Transmembrane | 598-618 | Helical; Name=12 | ||||
Sequence: ALAVIGLLVASSTMCIPLVAL | ||||||
Topological domain | 619-635 | Cytoplasmic | ||||
Sequence: GTFVTRHFKIREQFSAA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000214813 | 1-635 | Sodium- and chloride-dependent transporter XTRP3B | |||
Sequence: MESPSAHAVSLPEDEELQPWGGAGGPGQHPGRPRSTECAHPGVVEKVRPKWDNPLQFLLVCISYAVGLGNVWRFPYLCQMYGGGNFLVPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGIASLVVSFLASVYFNVINTWALWYLFHSFQDPLPWSVCPLNSNHTGYDEECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGKVVYFTTSLPYFVLIIYLVRGLTLHGATNGLAYMFTPKIEQLANPKAWINAATQIFFSLGLGCGGLIAFASYNEPSNDCQKHALIVSVINSTTAIFSSIVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTVSNLEEVKNYLASTYPNKYSEVFPHIRNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLTLGMGSMVGTGTAILTPLTDSKIISSYLPKEAISGLVCLLNCAIGMVFTMEAGNYWFDLFNDYTATLSLLLIVLVETIAVCYVYGLKRFESDLRAMTGRTLSWYWKVMWAFVSPLLIVGLFIFYLSDYILTGTLQYQAWDATQGHVVTKDYPTYALAVIGLLVASSTMCIPLVALGTFVTRHFKIREQFSAA | ||||||
Glycosylation | 174 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 400 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-38 | Disordered | ||||
Sequence: MESPSAHAVSLPEDEELQPWGGAGGPGQHPGRPRSTEC |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length635
- Mass (Da)70,687
- Last updated2011-07-27 v3
- Checksum465AD54AA807EBE3
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F7AVF9 | F7AVF9_MOUSE | Slc6a20b | 84 | ||
A0A803YV45 | A0A803YV45_MOUSE | Slc6a20b | 635 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 85 | in Ref. 1; AAC27756, 2; BAE25668/BAE37885 and 4; AAH13484 | ||||
Sequence: N → S |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF075261 EMBL· GenBank· DDBJ | AAC27756.1 EMBL· GenBank· DDBJ | mRNA | ||
AK144038 EMBL· GenBank· DDBJ | BAE25668.1 EMBL· GenBank· DDBJ | mRNA | ||
AK164706 EMBL· GenBank· DDBJ | BAE37885.1 EMBL· GenBank· DDBJ | mRNA | ||
AC132852 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC013484 EMBL· GenBank· DDBJ | AAH13484.1 EMBL· GenBank· DDBJ | mRNA |