O88573 · AFF1_MOUSE
- ProteinAF4/FMR2 family member 1
- GeneAff1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1216 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | super elongation complex | |
Cellular Component | transcription elongation factor complex | |
Molecular Function | DNA-binding transcription factor activity | |
Biological Process | DNA-templated transcription | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | regulation of gene expression |
Names & Taxonomy
Protein names
- Recommended nameAF4/FMR2 family member 1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO88573
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Keywords
- Disease
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000215911 | 1-1216 | AF4/FMR2 family member 1 | |||
Sequence: MAAHSSLYNEDRNLLRIREKERRNQEAHQEKEAFPEKAPLFPEPYKTAKGDELSSRIQTMLGDYEEMKEFLSSKSHPHRLDGSEDRPGKPRYPLGHDRGNGAASSSLRTHVYHQPIHTSAPGSRPVGNISHSPKMAQPRMEPSLHTKIYDGPRLTQDHLSQGHCSRKCDRRAEGDSAPERKLSPLISSLPSPVPPLSPVHSRLQGTSKAHSSGVSSKSCCVAKSSKDLVAKAQDKETPHDGLVAVTSLGSAPPQPPCQTFPPPPLPSKSAAMQQKPTAYVRPMDGQDQAPSESPELKLPLEDYGQQSFEKPDLKVPAKAKLTRLRMPSQSVEQPYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSRFPFPTKDPLHVSPATQSQKQYDTPSKTHPNPQQGTSMLEDDLQLSDSEDSDTEQATEKPPSPPAPPSAPQTLPEPVASAHSSSGESESSESDSSSDSESESSSSDSEEEEENEPLETRAPEPEPPTTNKWQLDNWLTKVNQPSVPLDGRGSTESPQWRQESKGVAEGSSDQQHPDSKDPLPKSSSKTLRGPSEGPSLGRGAVRNPPLNRNPHLGKPWAANNPGNPPRLRPGRAQASSQAESEVGPLPYGSKEQTSKDRPKVKTKGRPRAVGSREPKPEVPAPTPQAAVPRPKPPVPTPSEKRKHKSSTAPSKAPSAPQPPKDSAGDRNPEHSALVSLTQSQGPSHSSRGSSGSVRTSGCRQAVIAQGDGCKDKLLLPLRDTKLLSPLRDSPPPTSLVVKITLDLLTRIPQPLGKGSRPRKAEDKQLSAGKKQDSETKSCDSSSRVTKKRKVTQKKSTVTRDTNWISRRASSSSSHTESSRTKAPRSSSENSRKEMLPPASASSVSSSSSSQKPSRPAQKRPRPDEDTCSQEPPRSASSTKSSSTDPPAPKHRKVQARGSEHKGSSGDAANAANPFPVPSLPNGNAKPGKPQVKSDRQQADFHMKEAKKLKCKAETMVDKAGKAFKYLEAVLSFIECGMASESESSAKSAYAVYSETIDLIRYVMSLKCFSDNTMPAQEKIFAVLCLRCQSLLNMAMFRCKKDTVMKYSRTLSEHFKSTSKVAQAPSPCTARSTGVPSPLSPMPSPASSVGSQSSAGSSMGSVGVTATVSTPVSIQNMTSSYVTITSHVLTAFSLWEQAEALTRKNKEFFAQLSTKVRVLALNSSLVDLVHYTRQGLQRLKQSPKGP | ||||||
Modified residue | 183 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 191 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 197 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 682 | N6-acetyllysine | ||||
Sequence: K | ||||||
Modified residue | 755 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 760 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-52 | Disordered | ||||
Sequence: MAAHSSLYNEDRNLLRIREKERRNQEAHQEKEAFPEKAPLFPEPYKTAKGDE | ||||||
Compositional bias | 11-37 | Basic and acidic residues | ||||
Sequence: DRNLLRIREKERRNQEAHQEKEAFPEK | ||||||
Compositional bias | 68-93 | Basic and acidic residues | ||||
Sequence: KEFLSSKSHPHRLDGSEDRPGKPRYP | ||||||
Region | 68-104 | Disordered | ||||
Sequence: KEFLSSKSHPHRLDGSEDRPGKPRYPLGHDRGNGAAS | ||||||
Region | 116-139 | Disordered | ||||
Sequence: IHTSAPGSRPVGNISHSPKMAQPR | ||||||
Region | 152-217 | Disordered | ||||
Sequence: PRLTQDHLSQGHCSRKCDRRAEGDSAPERKLSPLISSLPSPVPPLSPVHSRLQGTSKAHSSGVSSK | ||||||
Compositional bias | 160-178 | Basic and acidic residues | ||||
Sequence: SQGHCSRKCDRRAEGDSAP | ||||||
Compositional bias | 200-217 | Polar residues | ||||
Sequence: HSRLQGTSKAHSSGVSSK | ||||||
Region | 244-275 | Disordered | ||||
Sequence: AVTSLGSAPPQPPCQTFPPPPLPSKSAAMQQK | ||||||
Compositional bias | 254-269 | Pro residues | ||||
Sequence: QPPCQTFPPPPLPSKS | ||||||
Region | 352-728 | Disordered | ||||
Sequence: SWPPPLTAIHTPSTAEPSRFPFPTKDPLHVSPATQSQKQYDTPSKTHPNPQQGTSMLEDDLQLSDSEDSDTEQATEKPPSPPAPPSAPQTLPEPVASAHSSSGESESSESDSSSDSESESSSSDSEEEEENEPLETRAPEPEPPTTNKWQLDNWLTKVNQPSVPLDGRGSTESPQWRQESKGVAEGSSDQQHPDSKDPLPKSSSKTLRGPSEGPSLGRGAVRNPPLNRNPHLGKPWAANNPGNPPRLRPGRAQASSQAESEVGPLPYGSKEQTSKDRPKVKTKGRPRAVGSREPKPEVPAPTPQAAVPRPKPPVPTPSEKRKHKSSTAPSKAPSAPQPPKDSAGDRNPEHSALVSLTQSQGPSHSSRGSSGSVRTSG | ||||||
Compositional bias | 380-411 | Polar residues | ||||
Sequence: HVSPATQSQKQYDTPSKTHPNPQQGTSMLEDD | ||||||
Compositional bias | 428-442 | Pro residues | ||||
Sequence: KPPSPPAPPSAPQTL | ||||||
Compositional bias | 444-470 | Polar residues | ||||
Sequence: EPVASAHSSSGESESSESDSSSDSESE | ||||||
Compositional bias | 471-486 | Acidic residues | ||||
Sequence: SSSSDSEEEEENEPLE | ||||||
Compositional bias | 497-540 | Polar residues | ||||
Sequence: TNKWQLDNWLTKVNQPSVPLDGRGSTESPQWRQESKGVAEGSSD | ||||||
Compositional bias | 647-665 | Pro residues | ||||
Sequence: PEVPAPTPQAAVPRPKPPV | ||||||
Compositional bias | 702-728 | Polar residues | ||||
Sequence: SALVSLTQSQGPSHSSRGSSGSVRTSG | ||||||
Region | 777-969 | Disordered | ||||
Sequence: RIPQPLGKGSRPRKAEDKQLSAGKKQDSETKSCDSSSRVTKKRKVTQKKSTVTRDTNWISRRASSSSSHTESSRTKAPRSSSENSRKEMLPPASASSVSSSSSSQKPSRPAQKRPRPDEDTCSQEPPRSASSTKSSSTDPPAPKHRKVQARGSEHKGSSGDAANAANPFPVPSLPNGNAKPGKPQVKSDRQQA | ||||||
Compositional bias | 786-817 | Basic and acidic residues | ||||
Sequence: SRPRKAEDKQLSAGKKQDSETKSCDSSSRVTK | ||||||
Compositional bias | 827-886 | Polar residues | ||||
Sequence: TVTRDTNWISRRASSSSSHTESSRTKAPRSSSENSRKEMLPPASASSVSSSSSSQKPSRP | ||||||
Compositional bias | 900-915 | Polar residues | ||||
Sequence: QEPPRSASSTKSSSTD | ||||||
Compositional bias | 916-930 | Basic and acidic residues | ||||
Sequence: PPAPKHRKVQARGSE | ||||||
Region | 1094-1125 | Disordered | ||||
Sequence: APSPCTARSTGVPSPLSPMPSPASSVGSQSSA |
Sequence similarities
Belongs to the AF4 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,216
- Mass (Da)131,558
- Last updated2012-10-03 v2
- Checksum4CCA54DBB4992E8B
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 11-37 | Basic and acidic residues | ||||
Sequence: DRNLLRIREKERRNQEAHQEKEAFPEK | ||||||
Compositional bias | 68-93 | Basic and acidic residues | ||||
Sequence: KEFLSSKSHPHRLDGSEDRPGKPRYP | ||||||
Compositional bias | 160-178 | Basic and acidic residues | ||||
Sequence: SQGHCSRKCDRRAEGDSAP | ||||||
Compositional bias | 200-217 | Polar residues | ||||
Sequence: HSRLQGTSKAHSSGVSSK | ||||||
Compositional bias | 254-269 | Pro residues | ||||
Sequence: QPPCQTFPPPPLPSKS | ||||||
Sequence conflict | 378 | in Ref. 1; AAD08668 | ||||
Sequence: P → L | ||||||
Compositional bias | 380-411 | Polar residues | ||||
Sequence: HVSPATQSQKQYDTPSKTHPNPQQGTSMLEDD | ||||||
Compositional bias | 428-442 | Pro residues | ||||
Sequence: KPPSPPAPPSAPQTL | ||||||
Compositional bias | 444-470 | Polar residues | ||||
Sequence: EPVASAHSSSGESESSESDSSSDSESE | ||||||
Compositional bias | 471-486 | Acidic residues | ||||
Sequence: SSSSDSEEEEENEPLE | ||||||
Compositional bias | 497-540 | Polar residues | ||||
Sequence: TNKWQLDNWLTKVNQPSVPLDGRGSTESPQWRQESKGVAEGSSD | ||||||
Sequence conflict | 619 | in Ref. 1; AAD08668 | ||||
Sequence: G → R | ||||||
Compositional bias | 647-665 | Pro residues | ||||
Sequence: PEVPAPTPQAAVPRPKPPV | ||||||
Compositional bias | 702-728 | Polar residues | ||||
Sequence: SALVSLTQSQGPSHSSRGSSGSVRTSG | ||||||
Compositional bias | 786-817 | Basic and acidic residues | ||||
Sequence: SRPRKAEDKQLSAGKKQDSETKSCDSSSRVTK | ||||||
Sequence conflict | 820 | in Ref. 1; AAD08668 | ||||
Sequence: K → R | ||||||
Compositional bias | 827-886 | Polar residues | ||||
Sequence: TVTRDTNWISRRASSSSSHTESSRTKAPRSSSENSRKEMLPPASASSVSSSSSSQKPSRP | ||||||
Sequence conflict | 838 | in Ref. 1; AAD08668 | ||||
Sequence: R → KT | ||||||
Compositional bias | 900-915 | Polar residues | ||||
Sequence: QEPPRSASSTKSSSTD | ||||||
Compositional bias | 916-930 | Basic and acidic residues | ||||
Sequence: PPAPKHRKVQARGSE |
Keywords
- Technical term