O88346 · TNNT1_MOUSE

  • Protein
    Troponin T, slow skeletal muscle
  • Gene
    Tnnt1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenttroponin complex
Molecular Functiontropomyosin binding
Molecular Functiontroponin T binding
Biological Processnegative regulation of muscle contraction
Biological Processsarcomere organization
Biological Processslow-twitch skeletal muscle fiber contraction
Biological Processtransition between fast and slow fiber

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Troponin T, slow skeletal muscle
  • Short names
    TnTs
  • Alternative names
    • Slow skeletal muscle troponin T (sTnT)

Gene names

    • Name
      Tnnt1

Organism names

  • Taxonomic identifier
  • Strains
    • 129
    • 129/SvJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O88346
  • Secondary accessions
    • B7ZNV5
    • B7ZNV6
    • O88795
    • Q9QUP7

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001861691-262Troponin T, slow skeletal muscle
Modified residue2Phosphoserine; by CK2

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in adult soleus muscle.

Developmental stage

In masseter expression decreases during development and becomes undetectable 3 weeks after birth.

Gene expression databases

Interaction

Subunit

Interacts with TPM3.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-31Acidic residues
Region1-62Disordered
Region109-153Disordered

Sequence similarities

Belongs to the troponin T family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

O88346-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    High Mr-1
  • Note
    Major.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    262
  • Mass (Da)
    31,344
  • Last updated
    2007-01-23 v3
  • Checksum
    E0B0FE519714FBE1
MSDTEEQEYEEEQAEDEEAVEEEEAPEEPEPVAEREEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELIALKDRIERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLESEKFDLMEKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK

O88346-2

  • Name
    2
  • Synonyms
    High Mr-2
  • Note
    Major.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

O88346-3

  • Name
    3
  • Synonyms
    Low Mr
  • Note
    Minor.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9QA86E9QA86_MOUSETnnt1207
E9PZB4E9PZB4_MOUSETnnt1168
E9PVN9E9PVN9_MOUSETnnt1118
E9Q688E9Q688_MOUSETnnt1249
E9Q334E9Q334_MOUSETnnt118
E9Q0G9E9Q0G9_MOUSETnnt1191

Features

Showing features for compositional bias, alternative sequence.

TypeIDPosition(s)Description
Compositional bias1-31Acidic residues
Alternative sequenceVSP_01378624-35in isoform 3
Alternative sequenceVSP_01378738in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF020946
EMBL· GenBank· DDBJ
AAC32546.1
EMBL· GenBank· DDBJ
mRNA
U92883
EMBL· GenBank· DDBJ
AAC32540.1
EMBL· GenBank· DDBJ
mRNA
U92884
EMBL· GenBank· DDBJ
AAC32541.1
EMBL· GenBank· DDBJ
mRNA
AJ131711
EMBL· GenBank· DDBJ
CAB38082.1
EMBL· GenBank· DDBJ
mRNA
U92882
EMBL· GenBank· DDBJ
AAD00730.1
EMBL· GenBank· DDBJ
Genomic DNA
BC141142
EMBL· GenBank· DDBJ
AAI41143.1
EMBL· GenBank· DDBJ
mRNA
BC145450
EMBL· GenBank· DDBJ
AAI45451.1
EMBL· GenBank· DDBJ
mRNA
BC145451
EMBL· GenBank· DDBJ
AAI45452.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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