O88335 · KCNJ1_MOUSE

  • Protein
    ATP-sensitive inward rectifier potassium channel 1
  • Gene
    Kcnj1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis.

Catalytic activity

Activity regulation

Inhibited by WNK3.

Features

Showing features for site, binding site.

137250100150200250300350
TypeIDPosition(s)Description
Site152Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium
Binding site204-211ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmonoatomic ion channel complex
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functioninward rectifier potassium channel activity
Biological Processcirculatory system development
Biological Processgene expression
Biological Processkidney development
Biological Processpost-embryonic development
Biological Processpotassium ion import across plasma membrane
Biological Processregulation of monoatomic ion transmembrane transport
Biological Processrenal sodium ion absorption
Biological Processtissue homeostasis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-sensitive inward rectifier potassium channel 1
  • Alternative names
    • ATP-regulated potassium channel ROM-K
    • Inward rectifier K(+) channel Kir1.1
    • Potassium channel, inwardly rectifying subfamily J member 1

Gene names

    • Name
      Kcnj1

Organism names

  • Taxonomic identifier
  • Strains
    • CD-1
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O88335

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane.

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-58Cytoplasmic
Transmembrane59-83Helical; Name=M1
Topological domain84-108Extracellular
Intramembrane109-120Helical; Pore-forming; Name=H5
Intramembrane121-127Pore-forming
Topological domain128-136Extracellular
Transmembrane137-158Helical; Name=M2
Topological domain159-372Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00001549181-372ATP-sensitive inward rectifier potassium channel 1
Modified residue25Phosphoserine; by SGK1
Glycosylation98N-linked (GlcNAc...) asparagine

Post-translational modification

Phosphorylation at Ser-25 by SGK1 is necessary for its expression at the cell membrane.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with SGK1 and SLC9A3R2/NHERF2.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif122-127Selectivity filter

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete

This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced.

O88335-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    372
  • Mass (Da)
    42,776
  • Last updated
    1998-11-01 v1
  • Checksum
    EA95D896622232D6
MFKHLRRWFVTHIFGRSRQRARLVSKDGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTPCVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYIPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFVLSEVDETDDTQM

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
G3UWE7G3UWE7_MOUSEKcnj1392

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF012834
EMBL· GenBank· DDBJ
AAC24973.1
EMBL· GenBank· DDBJ
mRNA
BC020525
EMBL· GenBank· DDBJ
AAH20525.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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