O88335 · KCNJ1_MOUSE
- ProteinATP-sensitive inward rectifier potassium channel 1
- GeneKcnj1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids372 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis.
Catalytic activity
- K+(in) = K+(out)
Activity regulation
Inhibited by WNK3.
Features
Showing features for site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | monoatomic ion channel complex | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | inward rectifier potassium channel activity | |
Biological Process | circulatory system development | |
Biological Process | gene expression | |
Biological Process | kidney development | |
Biological Process | post-embryonic development | |
Biological Process | potassium ion import across plasma membrane | |
Biological Process | regulation of monoatomic ion transmembrane transport | |
Biological Process | renal sodium ion absorption | |
Biological Process | tissue homeostasis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-sensitive inward rectifier potassium channel 1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO88335
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Note: Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane.
Features
Showing features for topological domain, transmembrane, intramembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-58 | Cytoplasmic | ||||
Sequence: MFKHLRRWFVTHIFGRSRQRARLVSKDGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKW | ||||||
Transmembrane | 59-83 | Helical; Name=M1 | ||||
Sequence: RYKMTVFITAFLGSWFLFGLLWYVV | ||||||
Topological domain | 84-108 | Extracellular | ||||
Sequence: AYVHKDLPEFYPPDNRTPCVENING | ||||||
Intramembrane | 109-120 | Helical; Pore-forming; Name=H5 | ||||
Sequence: MTSAFLFSLETQ | ||||||
Intramembrane | 121-127 | Pore-forming | ||||
Sequence: VTIGYGF | ||||||
Topological domain | 128-136 | Extracellular | ||||
Sequence: RFVTEQCAT | ||||||
Transmembrane | 137-158 | Helical; Name=M2 | ||||
Sequence: AIFLLIFQSILGVIINSFMCGA | ||||||
Topological domain | 159-372 | Cytoplasmic | ||||
Sequence: ILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYIPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFVLSEVDETDDTQM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000154918 | 1-372 | ATP-sensitive inward rectifier potassium channel 1 | |||
Sequence: MFKHLRRWFVTHIFGRSRQRARLVSKDGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTPCVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYIPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFVLSEVDETDDTQM | ||||||
Modified residue | 25 | Phosphoserine; by SGK1 | ||||
Sequence: S | ||||||
Glycosylation | 98 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
Phosphorylation at Ser-25 by SGK1 is necessary for its expression at the cell membrane.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 122-127 | Selectivity filter | ||||
Sequence: TIGYGF |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced.
O88335-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length372
- Mass (Da)42,776
- Last updated1998-11-01 v1
- ChecksumEA95D896622232D6
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
G3UWE7 | G3UWE7_MOUSE | Kcnj1 | 392 |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF012834 EMBL· GenBank· DDBJ | AAC24973.1 EMBL· GenBank· DDBJ | mRNA | ||
BC020525 EMBL· GenBank· DDBJ | AAH20525.1 EMBL· GenBank· DDBJ | mRNA |