O88200 · CLC11_MOUSE
- ProteinC-type lectin domain family 11 member A
- GeneClec11a
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids328 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Molecular Function | carbohydrate binding | |
Molecular Function | growth factor activity | |
Biological Process | ossification | |
Biological Process | positive regulation of cell population proliferation |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameC-type lectin domain family 11 member A
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO88200
- Secondary accessions
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Viable with no gross defects. Trabecular bone volume and bone mineral density is significantly reduced at two months of age, and progressively worsens with age. Bone strength is reduced and fracture healing is impaired. Hematopoiesis appears to be normal.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 13 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MQAAWLLGALVVPQLLSFGHG | ||||||
Chain | PRO_0000017469 | 22-328 | C-type lectin domain family 11 member A | |||
Sequence: ARGPGREWEGGWGGALEEERERESQMLKNLQEALGLPTGVGNEDNLAENPEDKEVWETTETQGEEEEEEITTAPSSSPNPFPSPSPTPEDTVTYILGRLASLDAGLHQLHVRLHVLDTRVVELTQGLRQLRDAASDTRDSVQALKEVQDRAEQEHGRLEGCLKGLRLGHKCFLLSRDFETQAAAQARCKARGGSLAQPADRQQMDALSRYLRAALAPYNWPVWLGVHDRRSEGLYLFENGQRVSFFAWHRAFSLESGAQPSAATHPLSPDQPNGGVLENCVAQASDDGSWWDHDCERRLYFVCEFPF | ||||||
Disulfide bond | 209↔324 | |||||
Sequence: CKARGGSLAQPADRQQMDALSRYLRAALAPYNWPVWLGVHDRRSEGLYLFENGQRVSFFAWHRAFSLESGAQPSAATHPLSPDQPNGGVLENCVAQASDDGSWWDHDCERRLYFVC | ||||||
Disulfide bond | 301↔316 | |||||
Sequence: CVAQASDDGSWWDHDC |
Post-translational modification
O-glycosylated. Probably sulfated on the O-glycans (By similarity).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Detected in femur where it localizes to trabecular bone of the femur metaphysis, and cortical bone of the proximal femur. Also expressed in trabecular and cortical bone of vertebrae (at protein level). Strongly expressed in osteoblasts and bone marrow stromal cells. Also has very weak expression in B cell progenitors in the bone marrow and T cells in the spleen.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 22-111 | Disordered | ||||
Sequence: ARGPGREWEGGWGGALEEERERESQMLKNLQEALGLPTGVGNEDNLAENPEDKEVWETTETQGEEEEEEITTAPSSSPNPFPSPSPTPED | ||||||
Compositional bias | 33-48 | Basic and acidic residues | ||||
Sequence: WGGALEEERERESQML | ||||||
Domain | 188-325 | C-type lectin | ||||
Sequence: LGHKCFLLSRDFETQAAAQARCKARGGSLAQPADRQQMDALSRYLRAALAPYNWPVWLGVHDRRSEGLYLFENGQRVSFFAWHRAFSLESGAQPSAATHPLSPDQPNGGVLENCVAQASDDGSWWDHDCERRLYFVCE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length328
- Mass (Da)36,451
- Last updated1998-11-01 v1
- Checksum309C17A861EE135C
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 33-48 | Basic and acidic residues | ||||
Sequence: WGGALEEERERESQML | ||||||
Sequence conflict | 114-117 | in Ref. 3; BAC31421 | ||||
Sequence: TYIL → FFTV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB009245 EMBL· GenBank· DDBJ | BAA32405.1 EMBL· GenBank· DDBJ | mRNA | ||
BC002001 EMBL· GenBank· DDBJ | AAH02001.3 EMBL· GenBank· DDBJ | mRNA | ||
AK042963 EMBL· GenBank· DDBJ | BAC31421.1 EMBL· GenBank· DDBJ | mRNA | ||
AK003813 EMBL· GenBank· DDBJ | BAB23010.1 EMBL· GenBank· DDBJ | mRNA |