O84735 · RIBD_CHLTR

Function

function

Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.
Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site55Zn2+ (UniProtKB | ChEBI); catalytic
Active site57Proton donor
Binding site80Zn2+ (UniProtKB | ChEBI); catalytic
Binding site89Zn2+ (UniProtKB | ChEBI); catalytic
Binding site159NADP+ (UniProtKB | ChEBI)
Binding site173substrate
Binding site175NADP+ (UniProtKB | ChEBI)
Binding site189substrate
Binding site201NADP+ (UniProtKB | ChEBI)
Binding site205NADP+ (UniProtKB | ChEBI)
Binding site209substrate
Binding site212substrate
Binding site230NADP+ (UniProtKB | ChEBI)
Binding site299substrate
Binding site301-307NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function5-amino-6-(5-phosphoribosylamino)uracil reductase activity
Molecular Functiondiaminohydroxyphosphoribosylaminopyrimidine deaminase activity
Molecular FunctionNADP binding
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Riboflavin biosynthesis protein RibD

Including 2 domains:

  • Recommended name
    Diaminohydroxyphosphoribosylaminopyrimidine deaminase
  • EC number
  • Short names
    DRAP deaminase
  • Alternative names
    • Riboflavin-specific deaminase
  • Recommended name
    5-amino-6-(5-phosphoribosylamino)uracil reductase
  • EC number
  • Alternative names
    • HTP reductase

Gene names

    • Name
      ribD
    • Ordered locus names
      CT_730

Organism names

Accessions

  • Primary accession
    O84735

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001717191-375Riboflavin biosynthesis protein RibD

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-150Deaminase
Domain6-127CMP/dCMP-type deaminase
Region151-375Reductase

Sequence similarities

In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.
In the C-terminal section; belongs to the HTP reductase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    375
  • Mass (Da)
    41,088
  • Last updated
    1998-11-01 v1
  • Checksum
    8E78F32BD73611E2
MEVLSEQQLFFMRKAVALGEKGRIFAPPNPWVGCVIVKNGCVIGEGWHQGIGSPHAEVCAVQDQKCSLEGAEVFVTLEPCCHFGRTPPCVDLLIKSKVAAVYVGLLDPDPRVCKKGVARLQAAGIPVYVGVGSQEAKTSLQPYLYQRERGLPWVVMKTAASLDGQTADRGGSSQWISGELARADVGKLRAESQAIIVGARTVCLDNPRLSARFPHGDLYERQPLRVVVDSRGTVPLESRVFDLSSGSTLFATTQQCPKEYIQKLKDLGVEVWESSSHQVDLKGLLRYLAERGCLQVLVEGGAQLHSAFWQQKLVNAGVIYWGPKFLGDQGQPMLRDLQLSLVTAEHVRITETSLVRDSVKTCFECLEQESVDKKG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE001273
EMBL· GenBank· DDBJ
AAC68325.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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