O84561 · DLDH_CHLTR

Function

function

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

Miscellaneous

The active site is a redox-active disulfide bond.

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site34-42FAD (UniProtKB | ChEBI)
Binding site51FAD (UniProtKB | ChEBI)
Binding site114FAD (UniProtKB | ChEBI)
Binding site180-184NAD+ (UniProtKB | ChEBI)
Binding site203NAD+ (UniProtKB | ChEBI)
Binding site237NAD+ (UniProtKB | ChEBI)
Binding site264-267NAD+ (UniProtKB | ChEBI)
Binding site307FAD (UniProtKB | ChEBI)
Binding site315FAD (UniProtKB | ChEBI)
Active site439Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondihydrolipoyl dehydrogenase activity
Molecular Functionflavin adenine dinucleotide binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrolipoyl dehydrogenase
  • EC number
  • Alternative names
    • Dihydrolipoamide dehydrogenase
    • E3 component of 2-oxoglutarate dehydrogenase complex

Gene names

    • Name
      lpdA
    • Ordered locus names
      CT_557

Organism names

Accessions

  • Primary accession
    O84561

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000680261-465Dihydrolipoyl dehydrogenase
Disulfide bond42↔47Redox-active

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    465
  • Mass (Da)
    49,491
  • Last updated
    1998-11-01 v1
  • Checksum
    56449CCD2AB61477
MNEAFDCVVIGAGPGGYVAAITAAQAGLKTALIEKREAGGTCLNRGCIPSKALLAGAEVVTQIRHADQFGIHVEGFSINYPAMVQRKDSVVRSIRDGLNGLIRSNKITVFSGRGSLISSTEVKILGENPSVIKAHSIILATGSEPRAFPGIPFSAESPRILCSTGVLNLKEIPQKMAIIGGGVIGCEFASLFHTLGSEVSVIEASSQILALNNPDISKTMFDKFTRQGLRFVLEASVSNIEDIGDRVRLTINGNVEEYDYVLVSIGRRLNTENIGLDKAGVICDERGVIPTDATMRTNVPNIYAIGDITGKWQLAHVASHQGIIAARNIAGHKEEIDYSAVPSVIFTFPEVASVGLSPTAAQQQKIPVKVTKFPFRAIGKAVAMGEADGFAAIISHETTQQILGAYVIGPHASSLISEITLAVRNELTLPCIYETIHAHPTLAEVWAESALLAVDTPLHMPPAKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE001273
EMBL· GenBank· DDBJ
AAC68159.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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