O82387 · CDC6A_ARATH

Function

function

May be involved in the initiation of DNA replication. May play a role in endoreduplication. Could act as one of the factors that contributes to maintain endoreduplication competence.

Miscellaneous

Cells expressing ectopically CDC6 have increased levels of endopolyploidy.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionATP hydrolysis activity
Biological Processcell division
Biological ProcessDNA endoreduplication
Biological ProcessDNA replication initiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cell division control protein 6 homolog
  • Short names
    AtCDC6
    ; AtCDC6A
    ; Cdc6At
    ; Cell division control protein 6 homolog A

Gene names

    • Name
      CDC6
    • Ordered locus names
      At2g29680

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    O82387
  • Secondary accessions
    • Q94CM2
    • Q94G54

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004329831-539Cell division control protein 6 homolog

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in roots, flower buds and etiolated seedlings. Expressed in leaves and stems (PubMed:11604464).
Highly expressed in proliferating cells such as root meristems, leaf primordia and young growing leaves, as well as cells undergoing endoreduplication cycles (PubMed:11752380).

Induction

Cell cycle regulated. Up-regulated at the G1/S phase transition and then decreases rapidly as cells progress into S-phase (PubMed:11669580, PubMed:11752380).
Degraded in a proteasome-dependent manner in proliferating cells, but not in endoreduplicating cells (PubMed:11752380).

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, motif.

TypeIDPosition(s)Description
Region1-40Disordered
Motif35-38Nuclear localization signal

Sequence similarities

Belongs to the CDC6/cdc18 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

O82387-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    539
  • Mass (Da)
    59,841
  • Last updated
    2002-06-01 v2
  • Checksum
    4D44B3BCEDC6E184
MPAIAGPSSSPQKHVVGSRSESIGGVRSAEVNTSRKRKLISDSAAEVSATVVLPVNSISTPMKWKSPRRCAVSIPKTSDEEIKEDSNEKLENPVISVCLEVKSKWNPKDDEQMKAVKEALHVSKAPSTVVCREDEQRRVFEFVKGCMEQKKAGSLYICGCPGTGKSLSMEKVRLQAEEWAKQAGLHCPETVSVNCTSLTKSTDIFSKILGNYESGKKANGSFSPLQQLQRLFSQKQQQSRSKMMLIIADEMDYLITRDRGVLHELFMLTTLPLSRCILIGTVFCVINVHFLKSVSYGQTSFKFKVRICPPGVANAIDLADRFLPKLKSLNCKPLVVTFRAYSKDQILRILQERLVALPFVAFQSNALEICARKVSAASGDMRKALCVCRSALEILEIEVRGSIDQEPKGPVPECQVVKMDHMIAALSKTFKSPIVDTIQSLPQHQQIIVCSAAKAFRGSKKDRTIAELNKLYLEICKSSMITPAGITEFSNMCTVLNDQGILKLSLARDDKLKRVSLRVDEADITFALKEIRFFRNCLL

O82387-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict76in Ref. 1; AAK68875
Sequence conflict94in Ref. 1; AAK68875
Sequence conflict273in Ref. 1; AAK68875
Alternative sequenceVSP_057638280-310in isoform 2
Sequence conflict506in Ref. 1; AAK68875

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF275940
EMBL· GenBank· DDBJ
AAK68875.1
EMBL· GenBank· DDBJ
mRNA
AJ271606
EMBL· GenBank· DDBJ
CAC81074.1
EMBL· GenBank· DDBJ
mRNA
AJ293020
EMBL· GenBank· DDBJ
CAC59688.1
EMBL· GenBank· DDBJ
mRNA
AC005496
EMBL· GenBank· DDBJ
AAC35241.2
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC08292.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC08293.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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