O82387 · CDC6A_ARATH
- ProteinCell division control protein 6 homolog
- GeneCDC6
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids539 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
May be involved in the initiation of DNA replication. May play a role in endoreduplication. Could act as one of the factors that contributes to maintain endoreduplication competence.
Miscellaneous
Cells expressing ectopically CDC6 have increased levels of endopolyploidy.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | ATP hydrolysis activity | |
Biological Process | cell division | |
Biological Process | DNA endoreduplication | |
Biological Process | DNA replication initiation |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCell division control protein 6 homolog
- Short namesAtCDC6 ; AtCDC6A ; Cdc6At ; Cell division control protein 6 homolog A
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionO82387
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000432983 | 1-539 | Cell division control protein 6 homolog | |||
Sequence: MPAIAGPSSSPQKHVVGSRSESIGGVRSAEVNTSRKRKLISDSAAEVSATVVLPVNSISTPMKWKSPRRCAVSIPKTSDEEIKEDSNEKLENPVISVCLEVKSKWNPKDDEQMKAVKEALHVSKAPSTVVCREDEQRRVFEFVKGCMEQKKAGSLYICGCPGTGKSLSMEKVRLQAEEWAKQAGLHCPETVSVNCTSLTKSTDIFSKILGNYESGKKANGSFSPLQQLQRLFSQKQQQSRSKMMLIIADEMDYLITRDRGVLHELFMLTTLPLSRCILIGTVFCVINVHFLKSVSYGQTSFKFKVRICPPGVANAIDLADRFLPKLKSLNCKPLVVTFRAYSKDQILRILQERLVALPFVAFQSNALEICARKVSAASGDMRKALCVCRSALEILEIEVRGSIDQEPKGPVPECQVVKMDHMIAALSKTFKSPIVDTIQSLPQHQQIIVCSAAKAFRGSKKDRTIAELNKLYLEICKSSMITPAGITEFSNMCTVLNDQGILKLSLARDDKLKRVSLRVDEADITFALKEIRFFRNCLL |
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in roots, flower buds and etiolated seedlings. Expressed in leaves and stems (PubMed:11604464).
Highly expressed in proliferating cells such as root meristems, leaf primordia and young growing leaves, as well as cells undergoing endoreduplication cycles (PubMed:11752380).
Highly expressed in proliferating cells such as root meristems, leaf primordia and young growing leaves, as well as cells undergoing endoreduplication cycles (PubMed:11752380).
Induction
Cell cycle regulated. Up-regulated at the G1/S phase transition and then decreases rapidly as cells progress into S-phase (PubMed:11669580, PubMed:11752380).
Degraded in a proteasome-dependent manner in proliferating cells, but not in endoreduplicating cells (PubMed:11752380).
Degraded in a proteasome-dependent manner in proliferating cells, but not in endoreduplicating cells (PubMed:11752380).
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-40 | Disordered | ||||
Sequence: MPAIAGPSSSPQKHVVGSRSESIGGVRSAEVNTSRKRKLI | ||||||
Motif | 35-38 | Nuclear localization signal | ||||
Sequence: RKRK |
Sequence similarities
Belongs to the CDC6/cdc18 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
O82387-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length539
- Mass (Da)59,841
- Last updated2002-06-01 v2
- Checksum4D44B3BCEDC6E184
O82387-2
- Name2
- Differences from canonical
- 280-310: Missing
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 76 | in Ref. 1; AAK68875 | ||||
Sequence: K → N | ||||||
Sequence conflict | 94 | in Ref. 1; AAK68875 | ||||
Sequence: V → E | ||||||
Sequence conflict | 273 | in Ref. 1; AAK68875 | ||||
Sequence: L → F | ||||||
Alternative sequence | VSP_057638 | 280-310 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 506 | in Ref. 1; AAK68875 | ||||
Sequence: L → H |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF275940 EMBL· GenBank· DDBJ | AAK68875.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ271606 EMBL· GenBank· DDBJ | CAC81074.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ293020 EMBL· GenBank· DDBJ | CAC59688.1 EMBL· GenBank· DDBJ | mRNA | ||
AC005496 EMBL· GenBank· DDBJ | AAC35241.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC08292.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC08293.1 EMBL· GenBank· DDBJ | Genomic DNA |