O82245 · TSPO_ARATH
- ProteinTranslocator protein homolog
- GeneTSPO
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids196 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Stress-induced membrane protein that can bind heme and may play a role in the transport of tetrapyrrole intermediates during salt stress and contribute to the detoxification of highly reactive porphyrins in the cytoplasm.
Miscellaneous
Plants overexpressing TSPO show increased sensitivity to ABA and salt stress. Cultured cells overexpressing TSPO have reduced greening and chlorophyll a content under light-growing conditions.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chloroplast membrane | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Cellular Component | Golgi stack | |
Cellular Component | membrane | |
Molecular Function | heme binding | |
Biological Process | porphyrin-containing compound metabolic process | |
Biological Process | response to abscisic acid | |
Biological Process | response to osmotic stress | |
Biological Process | response to salt stress |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameTranslocator protein homolog
- Short namesAtTSPO
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionO82245
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Plastid, chloroplast membrane ; Multi-pass membrane protein
Note: Localizes in chloroplast upon salt stress.
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 47-69 | Helical; Name=1 | ||||
Sequence: LKSLTVAVAAPVLVTLFATYFLG | ||||||
Transmembrane | 88-108 | Helical; Name=2 | ||||
Sequence: WLLHTTCLASSGLMGLAAWLV | ||||||
Transmembrane | 120-139 | Helical; Name=3 | ||||
Sequence: ALYLYLAQFLLCLVWDPVTF | ||||||
Transmembrane | 142-165 | Helical; Name=4 | ||||
Sequence: GSGVAGLAVWLGQSAALFGCYKAF | ||||||
Transmembrane | 174-196 | Helical; Name=5 | ||||
Sequence: NLVKPCLAWAAFVAAVNVKLAVA |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
No visible phenotype under normal growth conditions.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 91 | Unable to bind heme. | ||||
Sequence: H → A | ||||||
Mutagenesis | 115 | No effect on the ability to bind heme. | ||||
Sequence: H → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 8 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000415610 | 1-196 | Translocator protein homolog | |||
Sequence: MDSQDIRYRGGDDRDAATTAMAETERKSADDNKGKRDQKRAMAKRGLKSLTVAVAAPVLVTLFATYFLGTSDGYGNRAKSSSWIPPLWLLHTTCLASSGLMGLAAWLVWVDGGFHKKPNALYLYLAQFLLCLVWDPVTFRVGSGVAGLAVWLGQSAALFGCYKAFNEISPVAGNLVKPCLAWAAFVAAVNVKLAVA |
Proteomic databases
Expression
Tissue specificity
Specifically expressed in seeds (at protein level).
Induction
By abscisic acid (ABA) and osmotic and salt stresses (at protein level). Induced by methyl viologen.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-38 | Basic and acidic residues | ||||
Sequence: MDSQDIRYRGGDDRDAATTAMAETERKSADDNKGKRDQ | ||||||
Region | 1-40 | Disordered | ||||
Sequence: MDSQDIRYRGGDDRDAATTAMAETERKSADDNKGKRDQKR |
Sequence similarities
Belongs to the TspO/BZRP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length196
- Mass (Da)21,062
- Last updated1998-11-01 v1
- ChecksumACA367D6722291B3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-38 | Basic and acidic residues | ||||
Sequence: MDSQDIRYRGGDDRDAATTAMAETERKSADDNKGKRDQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC005309 EMBL· GenBank· DDBJ | AAC63632.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC10886.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF428356 EMBL· GenBank· DDBJ | AAL16286.1 EMBL· GenBank· DDBJ | mRNA | ||
AY045981 EMBL· GenBank· DDBJ | AAK76655.1 EMBL· GenBank· DDBJ | mRNA | ||
AY079391 EMBL· GenBank· DDBJ | AAL85122.1 EMBL· GenBank· DDBJ | mRNA |