O82245 · TSPO_ARATH

Function

function

Stress-induced membrane protein that can bind heme and may play a role in the transport of tetrapyrrole intermediates during salt stress and contribute to the detoxification of highly reactive porphyrins in the cytoplasm.

Miscellaneous

Plants overexpressing TSPO show increased sensitivity to ABA and salt stress. Cultured cells overexpressing TSPO have reduced greening and chlorophyll a content under light-growing conditions.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchloroplast membrane
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Cellular ComponentGolgi stack
Cellular Componentmembrane
Molecular Functionheme binding
Biological Processporphyrin-containing compound metabolic process
Biological Processresponse to abscisic acid
Biological Processresponse to osmotic stress
Biological Processresponse to salt stress

Keywords

Protein family/group databases

    • 9.A.24.1.3the mitochondrial cholesterol/porphyrin/5-aminolevulinic acid uptake translocator protein (tspo) family

Names & Taxonomy

Protein names

  • Recommended name
    Translocator protein homolog
  • Short names
    AtTSPO

Gene names

    • Name
      TSPO
    • ORF names
      F17A22.16
    • Ordered locus names
      At2g47770

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    O82245

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane47-69Helical; Name=1
Transmembrane88-108Helical; Name=2
Transmembrane120-139Helical; Name=3
Transmembrane142-165Helical; Name=4
Transmembrane174-196Helical; Name=5

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype under normal growth conditions.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis91Unable to bind heme.
Mutagenesis115No effect on the ability to bind heme.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 8 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004156101-196Translocator protein homolog

Proteomic databases

Expression

Tissue specificity

Specifically expressed in seeds (at protein level).

Induction

By abscisic acid (ABA) and osmotic and salt stresses (at protein level). Induced by methyl viologen.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-38Basic and acidic residues
Region1-40Disordered

Sequence similarities

Belongs to the TspO/BZRP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    196
  • Mass (Da)
    21,062
  • Last updated
    1998-11-01 v1
  • Checksum
    ACA367D6722291B3
MDSQDIRYRGGDDRDAATTAMAETERKSADDNKGKRDQKRAMAKRGLKSLTVAVAAPVLVTLFATYFLGTSDGYGNRAKSSSWIPPLWLLHTTCLASSGLMGLAAWLVWVDGGFHKKPNALYLYLAQFLLCLVWDPVTFRVGSGVAGLAVWLGQSAALFGCYKAFNEISPVAGNLVKPCLAWAAFVAAVNVKLAVA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-38Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC005309
EMBL· GenBank· DDBJ
AAC63632.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC10886.1
EMBL· GenBank· DDBJ
Genomic DNA
AF428356
EMBL· GenBank· DDBJ
AAL16286.1
EMBL· GenBank· DDBJ
mRNA
AY045981
EMBL· GenBank· DDBJ
AAK76655.1
EMBL· GenBank· DDBJ
mRNA
AY079391
EMBL· GenBank· DDBJ
AAL85122.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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