O82089 · CCH_ARATH
- ProteinCopper transport protein CCH
- GeneCCH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids121 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Involved in copper homeostasis. Can complement the yeast mutants atx1 and sod1.
Cofactor
Note: Binds 1 copper ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 13 | Cu cation (UniProtKB | ChEBI) | |||
Binding site | 16 | Cu cation (UniProtKB | ChEBI) | |||
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chloroplast | |
Cellular Component | cytosol | |
Molecular Function | copper chaperone activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein domain specific binding | |
Biological Process | copper ion transport | |
Biological Process | intracellular copper ion homeostasis | |
Biological Process | response to cadmium ion |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCopper transport protein CCH
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionO82089
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
No visible phenotype under normal growth conditions.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Modified residue | 2 | N-acetylalanine | |||
Chain | PRO_0000422761 | 2-121 | Copper transport protein CCH | ||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in phloem (at protein level).
Induction
Induced by copper deficiency, ozone and senescence. Down-regulated by excess of copper.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-65 | HMA | |||
Region | 70-121 | Disordered | |||
Compositional bias | 73-113 | Basic and acidic residues | |||
Sequence similarities
Belongs to the ATX1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length121
- Mass (Da)12,971
- Last updated1998-11-01 v1
- Checksum271D38907ED4012C
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1I9LNC0 | A0A1I9LNC0_ARATH | CCH | 111 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 73-113 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U88711 EMBL· GenBank· DDBJ | AAC33510.1 EMBL· GenBank· DDBJ | mRNA | ||
AL163763 EMBL· GenBank· DDBJ | CAB87423.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE79500.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | ANM64077.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF361860 EMBL· GenBank· DDBJ | AAK32872.1 EMBL· GenBank· DDBJ | mRNA | ||
AY066056 EMBL· GenBank· DDBJ | AAL47423.1 EMBL· GenBank· DDBJ | mRNA | ||
AY085657 EMBL· GenBank· DDBJ | AAM62878.1 EMBL· GenBank· DDBJ | mRNA |