O82035 · CADH2_PICAB

Function

function

Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Aromatic compound metabolism; phenylpropanoid biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site47Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site49NADP+ (UniProtKB | ChEBI)
Binding site69Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site70Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site100Zn2+ 2 (UniProtKB | ChEBI)
Binding site103Zn2+ 2 (UniProtKB | ChEBI)
Binding site106Zn2+ 2 (UniProtKB | ChEBI)
Binding site114Zn2+ 2 (UniProtKB | ChEBI)
Binding site163Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site167NADP+ (UniProtKB | ChEBI)
Binding site188-193NADP+ (UniProtKB | ChEBI)
Binding site211-216NADP+ (UniProtKB | ChEBI)
Binding site251NADP+ (UniProtKB | ChEBI)
Binding site275NADP+ (UniProtKB | ChEBI)
Binding site298-300NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncinnamyl-alcohol dehydrogenase activity
Molecular Functionconiferyl-alcohol dehydrogenase activity
Molecular Functionzinc ion binding
Biological Processlignin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cinnamyl alcohol dehydrogenase 2
  • EC number
  • Short names
    CAD 2

Gene names

    • Name
      CAD2

Organism names

Accessions

  • Primary accession
    O82035

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001607991-357Probable cinnamyl alcohol dehydrogenase 2

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    357
  • Mass (Da)
    38,834
  • Last updated
    1998-11-01 v1
  • Checksum
    56F8133B9E3097FC
MGSLESEKTVTGYAARDSSGHLSPYTYTLRNKGPEDVIVRVIYCGICHSDLVQMHNEMGMSNYPMVPGHEVVGVVTEIGSEVKKFKVGEHVGVGCIVGSCRSCSNCNGSMEQYCSKRIWTYNDVNHDGTPTQGGFASSMVVDQMFVVRIPENLPLEQAAPLLCAGVTVYSPMKHFGMTEPGKKCGILGLGGVGHMGVKIAKAFGLHVTVISSSDKKKEEALEVLGADAYLVSKDAEKMQEAAESLDYIMDTIPVAHPLEPYLALLKTNGKLVMLGVVPEPLHFVTPLLILGRRSIAGSFIGSMEETQETLDFCAEKKVSSMIEVVGLDYINTAMERLVKNDVRYRFVVDVARSNLDK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ001924
EMBL· GenBank· DDBJ
CAA05095.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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