O80961 · MLO12_ARATH
- ProteinMLO-like protein 12
- GeneMLO12
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids576 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca2+-dependent calmodulin binding and seems not to require heterotrimeric G proteins (By similarity).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | calmodulin binding | |
Biological Process | defense response | |
Biological Process | defense response to fungus | |
Biological Process | leaf senescence |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMLO-like protein 12
- Short namesAtMlo12; AtMlo18
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionO80961
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-13 | Extracellular | ||||
Sequence: MAIKERSLEETPT | ||||||
Transmembrane | 14-34 | Helical; Name=1 | ||||
Sequence: WAVAVVCFVLLFISIMIEYFL | ||||||
Topological domain | 35-59 | Cytoplasmic | ||||
Sequence: HFIGHWFKKKHKKALSEALEKVKAE | ||||||
Transmembrane | 60-80 | Helical; Name=2 | ||||
Sequence: LMLLGFISLLLVVLQTPVSEI | ||||||
Topological domain | 81-155 | Extracellular | ||||
Sequence: CIPRNIAATWHPCSNHQEIAKYGKDYIDDGRKILEDFDSNDFYSPRRNLATKGYDKCAEKGKVALVSAYGIHQLH | ||||||
Transmembrane | 156-176 | Helical; Name=3 | ||||
Sequence: IFIFVLAVFHVLYCIITYALG | ||||||
Topological domain | 177-278 | Cytoplasmic | ||||
Sequence: KTKMKKWKSWERETKTIEYQYANDPERFRFARDTSFGRRHLNIWSKSTFTLWITCFFRQFFGSVTKVDYLTLRHGFIMAHLPAGSAARFDFQKYIERSLEQD | ||||||
Transmembrane | 279-299 | Helical; Name=4 | ||||
Sequence: FTVVVGISPLIWCIAVLFILT | ||||||
Topological domain | 300-308 | Extracellular | ||||
Sequence: NTHGWDSYL | ||||||
Transmembrane | 309-329 | Helical; Name=5 | ||||
Sequence: WLPFLPLIVILIVGAKLQMII | ||||||
Topological domain | 330-362 | Cytoplasmic | ||||
Sequence: SKLGLRIQEKGDVVKGAPVVEPGDDLFWFGRPR | ||||||
Transmembrane | 363-383 | Helical; Name=6 | ||||
Sequence: FILFLIHLVLFTNAFQLAFFV | ||||||
Topological domain | 384-405 | Extracellular | ||||
Sequence: WSTYEFTLKNCFHHKTEDIAIR | ||||||
Transmembrane | 406-426 | Helical; Name=7 | ||||
Sequence: ITMGVLIQVLCSYITLPLYAL | ||||||
Topological domain | 427-576 | Cytoplasmic | ||||
Sequence: VTQMGTSMRPTIFNDRVANALKKWHHTAKKQTKHGHSGSNTPHSSRPTTPTHGMSPVHLLHNYNNRSLDQQTSFTASPSPPRFSDYSGQGHGHQHFFDPESQNHSYQREITDSEFSNSHHPQVDMASPVREEKEIVEHVKVDLSEFTFKK |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000209942 | 1-576 | MLO-like protein 12 | |||
Sequence: MAIKERSLEETPTWAVAVVCFVLLFISIMIEYFLHFIGHWFKKKHKKALSEALEKVKAELMLLGFISLLLVVLQTPVSEICIPRNIAATWHPCSNHQEIAKYGKDYIDDGRKILEDFDSNDFYSPRRNLATKGYDKCAEKGKVALVSAYGIHQLHIFIFVLAVFHVLYCIITYALGKTKMKKWKSWERETKTIEYQYANDPERFRFARDTSFGRRHLNIWSKSTFTLWITCFFRQFFGSVTKVDYLTLRHGFIMAHLPAGSAARFDFQKYIERSLEQDFTVVVGISPLIWCIAVLFILTNTHGWDSYLWLPFLPLIVILIVGAKLQMIISKLGLRIQEKGDVVKGAPVVEPGDDLFWFGRPRFILFLIHLVLFTNAFQLAFFVWSTYEFTLKNCFHHKTEDIAIRITMGVLIQVLCSYITLPLYALVTQMGTSMRPTIFNDRVANALKKWHHTAKKQTKHGHSGSNTPHSSRPTTPTHGMSPVHLLHNYNNRSLDQQTSFTASPSPPRFSDYSGQGHGHQHFFDPESQNHSYQREITDSEFSNSHHPQVDMASPVREEKEIVEHVKVDLSEFTFKK | ||||||
Modified residue | 505 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O80961 | GT-3B O80450 | 3 | EBI-17061436, EBI-1571089 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 441-462 | Calmodulin-binding | ||||
Sequence: DRVANALKKWHHTAKKQTKHGH | ||||||
Region | 450-557 | Disordered | ||||
Sequence: WHHTAKKQTKHGHSGSNTPHSSRPTTPTHGMSPVHLLHNYNNRSLDQQTSFTASPSPPRFSDYSGQGHGHQHFFDPESQNHSYQREITDSEFSNSHHPQVDMASPVRE | ||||||
Compositional bias | 460-478 | Polar residues | ||||
Sequence: HGHSGSNTPHSSRPTTPTH | ||||||
Compositional bias | 484-510 | Polar residues | ||||
Sequence: HLLHNYNNRSLDQQTSFTASPSPPRFS | ||||||
Compositional bias | 525-549 | Polar residues | ||||
Sequence: PESQNHSYQREITDSEFSNSHHPQV |
Domain
The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.
Sequence similarities
Belongs to the MLO family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length576
- Mass (Da)66,548
- Last updated2002-07-11 v2
- Checksum43DA9F6AED64D8E6
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 460-478 | Polar residues | ||||
Sequence: HGHSGSNTPHSSRPTTPTH | ||||||
Compositional bias | 484-510 | Polar residues | ||||
Sequence: HLLHNYNNRSLDQQTSFTASPSPPRFS | ||||||
Compositional bias | 525-549 | Polar residues | ||||
Sequence: PESQNHSYQREITDSEFSNSHHPQV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF369573 EMBL· GenBank· DDBJ | AAK53805.1 EMBL· GenBank· DDBJ | mRNA | ||
AC004697 EMBL· GenBank· DDBJ | AAC28997.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC09645.1 EMBL· GenBank· DDBJ | Genomic DNA |