O80931 · AS1_ARATH

Function

function

Transcription factor required for normal cell differentiation. Positively regulates LATERAL ORGAN BOUNDARIES (LOB) within the shoot apex, and the class III HD-ZIP genes REV, PHB, and PHV. Interacts directly with ASYMMETRIC LEAVES 2 (LBD6/AS2) to repress the knox homeobox genes BP/KNAT1, KNAT2, and KNAT6 and the abaxial determinants ARF3/ETT, KAN2 and YAB5. May act in parallel with the RDR6-SGS3-AGO7 pathway, an endogenous RNA silencing pathway, to regulate the leaf morphogenesis (PubMed:11076771, PubMed:11140682, PubMed:11882937, PubMed:12750468, PubMed:16006579, PubMed:16699177, PubMed:17395603, PubMed:17559509, PubMed:23271976).
Binds directly to KNAT1, KNAT2, and KNATM chromatin, regulating leaf development (PubMed:23271976).
LBD6 is required for this binding (PubMed:23271976).
Positive regulator of flowering that binds to the promoter of FT (PubMed:21950734).
Regulates FT expression by forming a functional complex with CO (PubMed:21950734).
Involved in leaf polarity establishment by functioning cooperatively with NUCL1 to repress abaxial genes ARF3, ARF4, KAN1, KAN2, YAB1 and YAB5, and the knox homeobox genes KNAT1, KNAT2, KNAT6, and STM to promote adaxial development in leaf primordia at shoot apical meristems at high temperatures (PubMed:27334696).

Features

Showing features for dna binding.

136750100150200250300350
TypeIDPosition(s)Description
DNA binding27-53H-T-H motif
DNA binding81-104H-T-H motif

GO annotations

AspectTerm
Cellular Componentcondensed chromosome
Cellular Componentnucleolus
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionidentical protein binding
Molecular Functionprotein homodimerization activity
Molecular Functiontranscription cis-regulatory region binding
Biological Processasymmetric cell division
Biological Processdefense response to bacterium
Biological Processdefense response to fungus
Biological Processflower development
Biological Processleaf formation
Biological Processleaf morphogenesis
Biological Processnegative regulation of DNA-templated transcription
Biological Processpolarity specification of adaxial/abaxial axis
Biological Processproximal/distal axis specification
Biological Processregulation of innate immune response
Biological Processresponse to virus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor AS1
  • Alternative names
    • Myb-related protein 91
      (AtMYB91
      )
    • Protein ASYMMETRIC LEAVES 1
    • Protein PHANTASTICA
      (AtPHAN
      )

Gene names

    • Name
      AS1
    • Synonyms
      MYB91
      , PHAN
    • ORF names
      F13M22.13
    • Ordered locus names
      At2g37630

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Columbia
    • cv. Landsberg erecta
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    O80931
  • Secondary accessions
    • Q53YQ1

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Plants with double mutations in this protein and in RH10 or AS2 protein have abaxialized filamentous and trumpet-like leaves at high temperatures. In double mutants, shapes of epidermal cells of the filamentous leaves are simple and rectangular, similar to those of a petiole, but different from those of flat leaves of wild-type plants.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001970731-367Transcription factor AS1

Proteomic databases

Expression

Tissue specificity

Expressed in roots, stems, leaves, flowers, siliques and in lateral organ promordia (PubMed:17559509).
Found in the inner domain between the adaxial and abaxial domains of leaves (PubMed:17559509).
Expressed in the phloem tissues of leaves, cotyledons, hypocotyls, and roots (PubMed:21950734).

Induction

Circadian-regulation with an afternoon peak in long days and with a broad night peak in short days (PubMed:21950734).
Expression of AS1 in stem cells of the shoot apical meristem is prevented by SHOOT MERISTEMLESS (STM). Expression is activated by GTE6 during leaf morphogenesis (PubMed:16166385).

Developmental stage

Preferential expression in young and immature plant tissues. In embryos, expressed from the late globular stage onwards. After germination, detected in leaf founder cells and on flowering, in primordia of all floral organs.

Gene expression databases

Interaction

Subunit

Homodimer (PubMed:12750468, PubMed:23271976).
Heterodimer with LBD6 (PubMed:23271976).
Interacts with LBD6/AS2, HIRA, a probable histone chaperone, and RIK, a predicted RNA binding protein (PubMed:12874130, PubMed:16243907).
Part of the AS1 repressor complex composed of AS1, LBD6/AS2 and HDA6 (PubMed:23271976).
Interacts with CO (PubMed:21950734).

Binary interactions

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, coiled coil.

TypeIDPosition(s)Description
Domain1-53HTH myb-type 1
Domain54-108HTH myb-type 2
Coiled coil260-344

Domain

A C-terminal domain (252-356) is required for dimerization.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    367
  • Mass (Da)
    42,243
  • Last updated
    1998-11-01 v1
  • Checksum
    24D9085193E6088B
MKERQRWSGEEDALLRAYVRQFGPREWHLVSERMNKPLNRDAKSCLERWKNYLKPGIKKGSLTEEEQRLVIRLQEKHGNKWKKIAAEVPGRTAKRLGKWWEVFKEKQQREEKESNKRVEPIDESKYDRILESFAEKLVKERSNVVPAAAAAATVVMANSNGGFLHSEQQVQPPNPVIPPWLATSNNGNNVVARPPSVTLTLSPSTVAAAAPQPPIPWLQQQQPERAENGPGGLVLGSMMPSCSGSSESVFLSELVECCRELEEGHRAWADHKKEAAWRLRRLELQLESEKTCRQREKMEEIEAKMKALREEQKNAMEKIEGEYREQLVGLRRDAEAKDQKLADQWTSRHIRLTKFLEQQMGCRLDRP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF175996
EMBL· GenBank· DDBJ
AAD53101.1
EMBL· GenBank· DDBJ
mRNA
AY519578
EMBL· GenBank· DDBJ
AAS10048.1
EMBL· GenBank· DDBJ
mRNA
AC004684
EMBL· GenBank· DDBJ
AAC23633.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC09428.1
EMBL· GenBank· DDBJ
Genomic DNA
BT026027
EMBL· GenBank· DDBJ
ABG48383.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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