O80501 · RAH1B_ARATH
- ProteinRas-related protein RABH1b
- GeneRABH1B
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids208 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Binds GTP and GDP and possesses intrinsic GTPase activity (By similarity).
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endosome | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Cellular Component | membrane | |
Cellular Component | plant-type vacuole | |
Cellular Component | plasma membrane | |
Cellular Component | plasmodesma | |
Cellular Component | trans-Golgi network | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Biological Process | exocytosis | |
Biological Process | plant-type cell wall cellulose biosynthetic process | |
Biological Process | protein transport | |
Biological Process | regulation of cell growth |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRas-related protein RABH1b
- Short namesAtRABH1b
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionO80501
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 23 | Loss of GTP-binding activity. No effect on targeting to Golgi. | ||||
Sequence: T → N | ||||||
Mutagenesis | 68 | No effect on GTP-binding activity and targeting to Golgi. | ||||
Sequence: Q → L | ||||||
Mutagenesis | 122 | Loss of GTP-binding activity and targeting to Golgi. Loss of GTP-binding activity; when associated with 206-C--C-208 Del. | ||||
Sequence: N → I | ||||||
Mutagenesis | 206 | Loss of targeting to Golgi; when associated with S-208. | ||||
Sequence: C → S | ||||||
Mutagenesis | 206-208 | No effect on GTP-binding activity. Loss of GTP-binding activity; when associated with I-122. | ||||
Sequence: Missing | ||||||
Mutagenesis | 208 | Loss of targeting to Golgi; when associated with S-206. | ||||
Sequence: C → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, lipidation, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000348542 | 1-208 | Ras-related protein RABH1b | |||
Sequence: MAPVSALAKYKLVFLGDQSVGKTSIITRFMYDKFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVIVYDVASRQSFLNTTKWIDEVRTERGSDVIVVLVGNKTDLVDKRQVSIEEAEAKARELNVMFIETSAKAGFNIKALFRKIAAALPGMETLSSTKQEDMVDVNLKSSNANASLAQQQSGGCSC | ||||||
Lipidation | 206 | S-geranylgeranyl cysteine | ||||
Sequence: C | ||||||
Modified residue | 208 | Cysteine methyl ester | ||||
Sequence: C | ||||||
Lipidation | 208 | S-geranylgeranyl cysteine | ||||
Sequence: C |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in roots, stems, leaves and flowers.
Gene expression databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 38-46 | Effector region | ||||
Sequence: YQATIGIDF |
Sequence similarities
Belongs to the small GTPase superfamily. Rab family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length208
- Mass (Da)23,130
- Last updated1998-11-01 v1
- ChecksumCD0EC2862AC7D0B7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC003672 EMBL· GenBank· DDBJ | AAC27463.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC10447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT025780 EMBL· GenBank· DDBJ | ABF83670.1 EMBL· GenBank· DDBJ | mRNA | ||
AK226988 EMBL· GenBank· DDBJ | BAE99055.1 EMBL· GenBank· DDBJ | mRNA | ||
AY087904 EMBL· GenBank· DDBJ | AAM65455.1 EMBL· GenBank· DDBJ | mRNA |