O77820 · O77820_RABIT

Function

function

Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentnuclear membrane
Cellular Componentplasma membrane
Molecular Functioncarboxylic ester hydrolase activity
Molecular Functionpalmitoyl-(protein) hydrolase activity
Biological Processprotein depalmitoylation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Acyl-protein thioesterase 1
  • EC number
  • Alternative names
    • Lysophospholipase 1
    • Lysophospholipase I
    • Palmitoyl-protein hydrolase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    O77820

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-214Phospholipase/carboxylesterase/thioesterase

Sequence similarities

Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,602
  • Last updated
    1998-11-01 v1
  • Checksum
    3B6A4FEDC3BC912B
ASVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVMPVTLNMNMAMPSWFDIIGLSPDSQEDEPGIKQAAENVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAEVTALSCWLPLRASFPQGPISGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U97147
EMBL· GenBank· DDBJ
AAC63431.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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