O77050 · O77050_HELCR
- ProteinTyrosine-protein kinase
- GeneAcSrc1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids517 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extrinsic component of cytoplasmic side of plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | non-membrane spanning protein tyrosine kinase activity | |
Molecular Function | signaling receptor binding | |
Biological Process | cell differentiation | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | innate immune response | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Echinodermata > Eleutherozoa > Echinozoa > Echinoidea > Euechinoidea > Echinacea > Camarodonta > Echinidea > Echinometridae > Heliocidaris
Accessions
- Primary accessionO77050
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-35 | Disordered | ||||
Sequence: MGCLQSKNAPSDHRTNKQETPSSNNRNSYNDNRPI | ||||||
Domain | 64-125 | SH3 | ||||
Sequence: NEVLTYIALYDYDARSESDLSFKKGEKLEILNNTDGDWWLAKSMVTGRDGYIPSNYIAPVKS | ||||||
Domain | 131-229 | SH2 | ||||
Sequence: WYFGKVGRKDAEKKLLAPGLQKGTFIVRDGEANPGTFSLSVRDYDPGKGEHIKHYRIRKLDNDSGYYITQRSQFQTLLELVHHYEGSADGLCCSLTNPC | ||||||
Domain | 251-506 | Protein kinase | ||||
Sequence: LKLDTKLGSGQFGEVWKGLWNGNTEVAVKTLRPKTMTPAAFLAEANIMKTCRHENLVQLYAVCSDMEPIYIVTELMKHGSLLDFLKDGDGRHLKLPQLVDMGAQVANGMAYLERKNYVHRDLAARNVLVNTGNICKVADFGLARMIQDDEYMARQGAKFPIKWTSPEAALYGRFTIKSDVWSFGILLTELIHYGRIPYPGMMNMEVLEQVERGYRMPRMNNCPDSLYDMCMMKCWHKDPQQRPTFEFLQGFLDDYF |
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length517
- Mass (Da)58,568
- Last updated1998-11-01 v1
- ChecksumD249A3DC358E3CA1