O75747 · P3C2G_HUMAN
- ProteinPhosphatidylinositol 3-kinase C2 domain-containing subunit gamma
- GenePIK3C2G
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1486 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (By similarity).
May play a role in SDF1A-stimulated chemotaxis (By similarity).
May play a role in SDF1A-stimulated chemotaxis (By similarity).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | membrane | |
Cellular Component | phosphatidylinositol 3-kinase complex | |
Cellular Component | plasma membrane | |
Molecular Function | 1-phosphatidylinositol-3-kinase activity | |
Molecular Function | 1-phosphatidylinositol-4-phosphate 3-kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | phosphatidylinositol binding | |
Molecular Function | phosphatidylinositol kinase activity | |
Biological Process | chemotaxis | |
Biological Process | modulation by host of viral process | |
Biological Process | phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | phosphatidylinositol-3-phosphate biosynthetic process | |
Biological Process | phosphatidylinositol-mediated signaling |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol 3-kinase C2 domain-containing subunit gamma
- EC number
- Short namesPI3K-C2-gamma; PtdIns-3-kinase C2 subunit gamma
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO75747
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_056676 | 146 | in dbSNP:rs11044004 | |||
Sequence: P → L | ||||||
Natural variant | VAR_056677 | 261 | in dbSNP:rs7133666 | |||
Sequence: A → E | ||||||
Natural variant | VAR_060323 | 952 | in dbSNP:rs12312266 | |||
Sequence: P → L | ||||||
Natural variant | VAR_060324 | 1331 | in dbSNP:rs12099555 | |||
Sequence: V → G | ||||||
Natural variant | VAR_060325 | 1483 | in dbSNP:rs12816860 | |||
Sequence: N → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,879 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000088799 | 1-1486 | Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma | |||
Sequence: MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIVDEISGKIPHYESEIDENTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVSKAPAIGFSPSVLPKPQNTNKECSWGSPIGKHHGADDSRFSILAPSFTSLDKINLEKELENENHNYHIGFESSIPPTNSSFSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWESTWQKNIESIGCSIQLVEVPQSSNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHIFIDNSTQPLHFMPCANYLVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKSVIQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKVSRQCLLTLIRKYDFHLKYLLKTQENVYNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENFYQSSETSAKGLIEKVTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWVHSYKAFSFTCWLTYAGKKLCQVRNYRNIPDKKLFFFLVNWNETINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQSEPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLLSTTRSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPEFPHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPVYLGEKFPDKKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWYPLGNSII |
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 285-371 | PI3K-RBD | ||||
Sequence: KTKFNIHIFIDNSTQPLHFMPCANYLVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKSVIQLHLQKSRE | ||||||
Domain | 521-669 | C2 PI3K-type | ||||
Sequence: LPSHLSFTVYAAHNIPETWVHSYKAFSFTCWLTYAGKKLCQVRNYRNIPDKKLFFFLVNWNETINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQSEPPVEMITPGVWDVSQPSPVTLQIDFP | ||||||
Domain | 684-860 | PIK helical | ||||
Sequence: RSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFC | ||||||
Domain | 929-1207 | PI3K/PI4K catalytic | ||||
Sequence: DHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLECFP | ||||||
Region | 935-941 | G-loop | ||||
Sequence: YFTSNAL | ||||||
Region | 1071-1079 | Catalytic loop | ||||
Sequence: GVCDRHNDN | ||||||
Region | 1090-1116 | Activation loop | ||||
Sequence: HIDFGKFLGHAQTFGGIKRDRAPFIFT | ||||||
Domain | 1240-1352 | PX | ||||
Sequence: LSTTRSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPEFPHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQ | ||||||
Domain | 1369-1486 | C2 | ||||
Sequence: KKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWYPLGNSII |
Sequence similarities
Belongs to the PI3/PI4-kinase family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
O75747-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,486
- Mass (Da)170,682
- Last updated2024-01-24 v4
- ChecksumE1D981018DD2B052
O75747-2
- Name2
- Differences from canonical
- 542-583: SYKAFSFTCWLTYAGKKLCQVRNYRNIPDKKLFFFLVNWNET → R
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A087WV31 | A0A087WV31_HUMAN | PIK3C2G | 187 | ||
F5GWG6 | F5GWG6_HUMAN | PIK3C2G | 231 | ||
F5H7Y7 | F5H7Y7_HUMAN | PIK3C2G | 583 |
Sequence caution
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 129 | in Ref. 3; EAW96387 and 4; AAI30278 | ||||
Sequence: Missing | ||||||
Alternative sequence | VSP_062039 | 542-583 | in isoform 2 | |||
Sequence: SYKAFSFTCWLTYAGKKLCQVRNYRNIPDKKLFFFLVNWNET → R | ||||||
Sequence conflict | 1006 | in Ref. 1; CAA03853 | ||||
Sequence: G → R | ||||||
Sequence conflict | 1250 | in Ref. 1; CAA03853 | ||||
Sequence: Missing | ||||||
Sequence conflict | 1355 | in Ref. 1; CAA03853 | ||||
Sequence: Missing | ||||||
Sequence conflict | 1364 | in Ref. 1; CAA03853 | ||||
Sequence: E → EK | ||||||
Sequence conflict | 1418 | in Ref. 1; CAA03853 | ||||
Sequence: R → L |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ000008 EMBL· GenBank· DDBJ | CAA03853.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AC087236 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC087240 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC091815 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC092851 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF455618 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471094 EMBL· GenBank· DDBJ | EAW96387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC130277 EMBL· GenBank· DDBJ | AAI30278.1 EMBL· GenBank· DDBJ | mRNA |