O75688 · PPM1B_HUMAN
- ProteinProtein phosphatase 1B
- GenePPM1B
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids479 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalytic activity
- H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | membrane | |
Cellular Component | nucleolus | |
Cellular Component | nucleus | |
Molecular Function | magnesium ion binding | |
Molecular Function | manganese ion binding | |
Molecular Function | myosin phosphatase activity | |
Molecular Function | protein serine/threonine phosphatase activity | |
Biological Process | N-terminal protein myristoylation | |
Biological Process | negative regulation of canonical NF-kappaB signal transduction | |
Biological Process | negative regulation of defense response to virus | |
Biological Process | negative regulation of interferon-beta production | |
Biological Process | negative regulation of non-canonical NF-kappaB signal transduction | |
Biological Process | peptidyl-threonine dephosphorylation | |
Biological Process | positive regulation of canonical Wnt signaling pathway | |
Biological Process | protein dephosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein phosphatase 1B
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO75688
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 562 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, lipidation, chain, cross-link, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Initiator methionine | 1 | UniProt | Removed | ||||
Sequence: M | |||||||
Lipidation | 2 | UniProt | N-myristoyl glycine | ||||
Sequence: G | |||||||
Chain | PRO_0000057746 | 2-479 | UniProt | Protein phosphatase 1B | |||
Sequence: GAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSYRLAKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEKI | |||||||
Cross-link | 12 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) | ||||
Sequence: K | |||||||
Cross-link | 142 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 195 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 376 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 380 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 386 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 386 | PRIDE | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with PAK6. Interacts with the phosphorylated form of IKBKB/IKKB
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O75688 | ARRB1 P49407 | 4 | EBI-1047039, EBI-743313 | |
BINARY | O75688 | ARRB2 P32121 | 4 | EBI-1047039, EBI-714559 | |
BINARY | O75688 | ISG15 P05161 | 2 | EBI-1047039, EBI-746466 | |
BINARY | O75688-3 | MAD2L2 Q9UI95 | 3 | EBI-17715099, EBI-77889 | |
BINARY | O75688-3 | MYL7 Q01449 | 3 | EBI-17715099, EBI-10222416 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: MGAFLDKPKTEKHNAH | ||||||
Region | 1-20 | Disordered | ||||
Sequence: MGAFLDKPKTEKHNAHGAGN | ||||||
Domain | 23-295 | PPM-type phosphatase | ||||
Sequence: RYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCF | ||||||
Region | 423-479 | Disordered | ||||
Sequence: VEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEKI | ||||||
Compositional bias | 432-470 | Polar residues | ||||
Sequence: PAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDA |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
O75688-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameBeta-1
- SynonymsBeta-X, PPM1B2
- Length479
- Mass (Da)52,643
- Last updated1998-11-01 v1
- ChecksumA3A5797AD263DFBD
O75688-2
- NameBeta-2
- SynonymsPPM1B1
O75688-3
- NameBeta-X
- Differences from canonical
- 1-287: Missing
O75688-4
- Name4
O75688-5
- Name5
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: MGAFLDKPKTEKHNAH | ||||||
Alternative sequence | VSP_041085 | 1-287 | in isoform Beta-X | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_043641 | 322-327 | in isoform 5 | |||
Sequence: EIMEKS → GKTNAF | ||||||
Alternative sequence | VSP_043642 | 328-380 | in isoform 5 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_043643 | 379-380 | in isoform 4 | |||
Sequence: AS → QK | ||||||
Alternative sequence | VSP_005087 | 379-387 | in isoform Beta-2 | |||
Sequence: ASDEAEESG → GAGDLEDPW | ||||||
Alternative sequence | VSP_043644 | 381-387 | in isoform 4 and isoform 5 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_005088 | 388-479 | in isoform Beta-2, isoform 4 and isoform 5 | |||
Sequence: Missing | ||||||
Compositional bias | 432-470 | Polar residues | ||||
Sequence: PAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDA |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ005801 EMBL· GenBank· DDBJ | CAA06704.1 EMBL· GenBank· DDBJ | mRNA | ||
AF294792 EMBL· GenBank· DDBJ | AAG02232.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ271832 EMBL· GenBank· DDBJ | CAC27992.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ271835 EMBL· GenBank· DDBJ | CAC27993.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ023508 EMBL· GenBank· DDBJ | AAY89639.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ023509 EMBL· GenBank· DDBJ | AAY89640.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ023510 EMBL· GenBank· DDBJ | AAY89641.1 EMBL· GenBank· DDBJ | mRNA | ||
AF136972 EMBL· GenBank· DDBJ | AAG49433.1 EMBL· GenBank· DDBJ | mRNA | ||
AL833035 EMBL· GenBank· DDBJ | CAH56319.1 EMBL· GenBank· DDBJ | mRNA | ||
AC013717 EMBL· GenBank· DDBJ | AAX88954.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC019129 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471053 EMBL· GenBank· DDBJ | EAX00282.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471053 EMBL· GenBank· DDBJ | EAX00283.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC012002 EMBL· GenBank· DDBJ | AAH12002.1 EMBL· GenBank· DDBJ | mRNA | ||
BC064381 EMBL· GenBank· DDBJ | AAH64381.1 EMBL· GenBank· DDBJ | mRNA |