O75631 · UPK3A_HUMAN
- ProteinUroplakin-3a
- GeneUPK3A
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids287 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane urothelial plaque | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | extracellular exosome | |
Cellular Component | plasma membrane | |
Biological Process | cell morphogenesis | |
Biological Process | epithelial cell differentiation | |
Biological Process | kidney development | |
Biological Process | potassium ion homeostasis | |
Biological Process | sodium ion homeostasis | |
Biological Process | urea transport | |
Biological Process | urinary bladder development | |
Biological Process | water transport |
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameUroplakin-3a
- Short namesUP3a
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO75631
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Note: Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 19-207 | Lumenal | ||||
Sequence: VNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQLTPYSTIDTWPGRRSGG | ||||||
Transmembrane | 208-235 | Helical | ||||
Sequence: MIVITSILGSLPFFLLVGFAGAIALSLV | ||||||
Topological domain | 236-287 | Cytoplasmic | ||||
Sequence: DMGSSDGETTHDSQITQEAVPKSLGASESSYTSVNRGPPLDRAEVYSSKLQD |
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_044399 | 91 | in dbSNP:rs6006979 | |||
Sequence: Q → L | ||||||
Natural variant | VAR_020158 | 154 | in dbSNP:rs1057353 | |||
Sequence: A → P | ||||||
Natural variant | VAR_044400 | 202 | found in a patient with unilateral multicystic kidney disease; uncertain significance; dbSNP:rs121918187 | |||
Sequence: G → D | ||||||
Natural variant | VAR_044401 | 273 | found in patients with renal adysplasia; uncertain significance; normal targeting to the cell surface; dbSNP:rs121918186 | |||
Sequence: P → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 387 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MPPLWALLALGCLRFGSA | ||||||
Chain | PRO_0000022637 | 19-287 | Uroplakin-3a | |||
Sequence: VNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAGAIALSLVDMGSSDGETTHDSQITQEAVPKSLGASESSYTSVNRGPPLDRAEVYSSKLQD | ||||||
Glycosylation | 74 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 139 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 170 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Heterodimer with uroplakin-1B (UPK1B).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O75631 | SGTA O43765 | 3 | EBI-10188907, EBI-347996 | |
BINARY | O75631 | SGTB Q96EQ0 | 3 | EBI-10188907, EBI-744081 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 242-271 | Polar residues | ||||
Sequence: GETTHDSQITQEAVPKSLGASESSYTSVNR | ||||||
Region | 242-287 | Disordered | ||||
Sequence: GETTHDSQITQEAVPKSLGASESSYTSVNRGPPLDRAEVYSSKLQD |
Sequence similarities
Belongs to the uroplakin-3 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
O75631-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length287
- Mass (Da)30,670
- Last updated2004-10-11 v3
- Checksum2A14B21746FDBD25
O75631-2
- Name2
- Differences from canonical
- 70-191: AISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQL → V
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_030004 | 70-191 | in isoform 2 | |||
Sequence: AISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQL → V | ||||||
Sequence conflict | 236 | in Ref. 2; BAA31460/BAA25678 | ||||
Sequence: D → A | ||||||
Compositional bias | 242-271 | Polar residues | ||||
Sequence: GETTHDSQITQEAVPKSLGASESSYTSVNR |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF085808 EMBL· GenBank· DDBJ | AAC34888.1 EMBL· GenBank· DDBJ | mRNA | ||
AB010637 EMBL· GenBank· DDBJ | BAA31460.1 EMBL· GenBank· DDBJ | mRNA | ||
AB010116 EMBL· GenBank· DDBJ | BAA25678.1 EMBL· GenBank· DDBJ | mRNA | ||
CR456608 EMBL· GenBank· DDBJ | CAG30494.1 EMBL· GenBank· DDBJ | mRNA | ||
AL008718 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC069544 EMBL· GenBank· DDBJ | AAH69544.1 EMBL· GenBank· DDBJ | mRNA | ||
BC108900 EMBL· GenBank· DDBJ | AAI08901.1 EMBL· GenBank· DDBJ | mRNA |