O75631 · UPK3A_HUMAN

  • Protein
    Uroplakin-3a
  • Gene
    UPK3A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane urothelial plaque
Cellular Componentendoplasmic reticulum membrane
Cellular Componentextracellular exosome
Cellular Componentplasma membrane
Biological Processcell morphogenesis
Biological Processepithelial cell differentiation
Biological Processkidney development
Biological Processpotassium ion homeostasis
Biological Processsodium ion homeostasis
Biological Processurea transport
Biological Processurinary bladder development
Biological Processwater transport

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Uroplakin-3a
  • Short names
    UP3a
  • Alternative names
    • Uroplakin III (UPIII)

Gene names

    • Name
      UPK3A
    • Synonyms
      UPK3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O75631
  • Secondary accessions
    • B0QY25
    • O60261
    • Q32N05
    • Q5TII6

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type I membrane protein
Note: Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain19-207Lumenal
Transmembrane208-235Helical
Topological domain236-287Cytoplasmic

Keywords

Disease & Variants

Involvement in disease

  • Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_04439991in dbSNP:rs6006979
Natural variantVAR_020158154in dbSNP:rs1057353
Natural variantVAR_044400202found in a patient with unilateral multicystic kidney disease; uncertain significance; dbSNP:rs121918187
Natural variantVAR_044401273found in patients with renal adysplasia; uncertain significance; normal targeting to the cell surface; dbSNP:rs121918186

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 387 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000002263719-287Uroplakin-3a
Glycosylation74N-linked (GlcNAc...) asparagine
Glycosylation139N-linked (GlcNAc...) asparagine
Glycosylation170N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in ureter.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Heterodimer with uroplakin-1B (UPK1B).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O75631SGTA O437653EBI-10188907, EBI-347996
BINARY O75631SGTB Q96EQ03EBI-10188907, EBI-744081

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias242-271Polar residues
Region242-287Disordered

Sequence similarities

Belongs to the uroplakin-3 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

O75631-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    287
  • Mass (Da)
    30,670
  • Last updated
    2004-10-11 v3
  • Checksum
    2A14B21746FDBD25
MPPLWALLALGCLRFGSAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAGAIALSLVDMGSSDGETTHDSQITQEAVPKSLGASESSYTSVNRGPPLDRAEVYSSKLQD

O75631-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 70-191: AISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQL → V

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_03000470-191in isoform 2
Sequence conflict236in Ref. 2; BAA31460/BAA25678
Compositional bias242-271Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF085808
EMBL· GenBank· DDBJ
AAC34888.1
EMBL· GenBank· DDBJ
mRNA
AB010637
EMBL· GenBank· DDBJ
BAA31460.1
EMBL· GenBank· DDBJ
mRNA
AB010116
EMBL· GenBank· DDBJ
BAA25678.1
EMBL· GenBank· DDBJ
mRNA
CR456608
EMBL· GenBank· DDBJ
CAG30494.1
EMBL· GenBank· DDBJ
mRNA
AL008718
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC069544
EMBL· GenBank· DDBJ
AAH69544.1
EMBL· GenBank· DDBJ
mRNA
BC108900
EMBL· GenBank· DDBJ
AAI08901.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp