O75343 · GCYB2_HUMAN
- ProteinGuanylate cyclase soluble subunit beta-2
- GeneGUCY1B2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids617 (go to sequence)
- Protein existenceUncertain
- Annotation score5/5
Function
Miscellaneous
There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.
Catalytic activity
- GTP = 3',5'-cyclic GMP + diphosphate
Cofactor
Note: Binds 1 or 2 heme groups per heterodimer.
Activity regulation
Activated by nitric oxide in the presence of magnesium or manganese ions.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | guanylate cyclase complex, soluble | |
Molecular Function | GTP binding | |
Molecular Function | guanylate cyclase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | cGMP-mediated signaling | |
Biological Process | response to oxygen levels |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGuanylate cyclase soluble subunit beta-2
- EC number
- Short namesGCS-beta-2
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO75343
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_024469 | 55 | in dbSNP:rs9568497 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_024470 | 128 | in dbSNP:rs11841997 | |||
Sequence: M → I | ||||||
Natural variant | VAR_022131 | 316 | in dbSNP:rs1328361 | |||
Sequence: N → H |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000074119 | 1-617 | Guanylate cyclase soluble subunit beta-2 | |||
Sequence: MSGYDRMLRTLGGNLMEFIENLDALHSYLALSYQEMNAPSFRVERGADGKMFLHYYSDRSGLCHIVPGIIEAVAKDFFDIDVIMDILDMNEEVERTGKKEHVVFLIVQKAHRKMRKTKPKRLQDSQGMERDQEALQAAFLKMKEKYLNVSACPVKKSHWDVVRSIVMFGKGHLMNTFEPIYPERLWIEEKTFCNAFPFHIVFDESLQVKQARVNIQKYVPGLQTQNIQLDEYFSIIHPQVTFNIFSIRRFINSQFVLKTRREMMPVAWQSRTTLKLQGQMIWMESMWCMVYLCSPKLRSLQELEELNMHLSDIAPNDTTRDLILLNQQRLAEIELSNQLERKKEELQVLSKHLAIEKKKTETLLYAMLPKHVANQLREGKKVAAGEFKSCTILFSDVVTFTNICTACEPIQIVNVLNSMYSKFDRLTSVHAVYKVETIGDAYMVVGGVPVPIGNHAQRVANFALGMRISAKEVTNPVTGEPIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAYRALKNQGFKIIERGEIEVKGKGRMTTYFLIQNLNATEDEIMGRSKTPVDHKGSTQKASLPTTKLQGSVQPSCPEHSSLASWLL |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in gastric signet ring cell carcinoma, but not in the normal stomach.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 391-519 | Guanylate cyclase | ||||
Sequence: TILFSDVVTFTNICTACEPIQIVNVLNSMYSKFDRLTSVHAVYKVETIGDAYMVVGGVPVPIGNHAQRVANFALGMRISAKEVTNPVTGEPIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNTASRME | ||||||
Region | 577-605 | Disordered | ||||
Sequence: RSKTPVDHKGSTQKASLPTTKLQGSVQPS | ||||||
Compositional bias | 585-605 | Polar residues | ||||
Sequence: KGSTQKASLPTTKLQGSVQPS |
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length617
- Mass (Da)70,368
- Last updated2001-07-11 v2
- Checksum1B6C965CAB9A5E3E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 585-605 | Polar residues | ||||
Sequence: KGSTQKASLPTTKLQGSVQPS |
Keywords
- Technical term