O75192 · PX11A_HUMAN

  • Protein
    Peroxisomal membrane protein 11A
  • Gene
    PEX11A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May be involved in peroxisomal proliferation and may regulate peroxisomes division (PubMed:9792670).
May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity).
Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentperoxisomal membrane
Cellular Componentperoxisome
Cellular Componentprotein-containing complex
Molecular Functionprotein homodimerization activity
Biological Processbrown fat cell differentiation
Biological Processperoxisome fission
Biological Processperoxisome membrane biogenesis
Biological Processperoxisome organization
Biological Processregulation of peroxisome size
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxisomal membrane protein 11A
  • Short names
    HsPEX11p
  • Alternative names
    • 28 kDa peroxisomal integral membrane protein (PMP28)
    • Peroxin-11A
    • Peroxisomal biogenesis factor 11A
    • Protein PEX11 homolog alpha (PEX11-alpha)

Gene names

    • Name
      PEX11A
    • Synonyms
      PEX11

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O75192
  • Secondary accessions
    • B4DV88

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-83Cytoplasmic
Transmembrane84-105Helical
Topological domain106-219Lumenal
Transmembrane220-239Helical
Topological domain240-247Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis9No effect on peroxisomal location.
Mutagenesis243-245No effect on peroxisomal location.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 478 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001059641-247Peroxisomal membrane protein 11A

Post-translational modification

Seems not to be N-glycosylated.

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homodimer (PubMed:20826455).
Heterodimer with PEX11G (PubMed:20826455).
Probably interacts with COPB2 and COPA (By similarity).
Interacts with PEX19 (PubMed:10704444).
Interacts with FIS1 (PubMed:20826455).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region220-239Required for homodimerization, interaction with PEX11G, and peroxisomal localization

Sequence similarities

Belongs to the peroxin-11 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

O75192-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    247
  • Mass (Da)
    28,353
  • Last updated
    1998-11-01 v1
  • Checksum
    D904EC715271FF87
MDAFTRFTNQTQGRDRLFRATQYTCMLLRYLLEPKAGKEKVVMKLKKLESSVSTGRKWFRLGNVVHAIQATEQSIHATDLVPRLCLTLANLNRVIYFICDTILWVRSVGLTSGINKEKWRTRAAHHYYYSLLLSLVRDLYEISLQMKRVTCDRAKKEKSASQDPLWFSVAEEETEWLQSFLLLLFRSLKQHPPLLLDTVKNLCDILNPLDQLGIYKSNPGIIGLGGLVSSIAGMITVAYPQMKLKTR

O75192-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 58-89: WFRLGNVVHAIQATEQSIHATDLVPRLCLTLA → S

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YN61H0YN61_HUMANPEX11A32
H0YMC7H0YMC7_HUMANPEX11A64

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_05475358-89in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB015594
EMBL· GenBank· DDBJ
BAA32533.1
EMBL· GenBank· DDBJ
mRNA
AF093668
EMBL· GenBank· DDBJ
AAC78658.1
EMBL· GenBank· DDBJ
mRNA
CR542046
EMBL· GenBank· DDBJ
CAG46843.1
EMBL· GenBank· DDBJ
mRNA
CR542075
EMBL· GenBank· DDBJ
CAG46872.1
EMBL· GenBank· DDBJ
mRNA
AK300978
EMBL· GenBank· DDBJ
BAG62600.1
EMBL· GenBank· DDBJ
mRNA
AC013787
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC009697
EMBL· GenBank· DDBJ
AAH09697.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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