O75192 · PX11A_HUMAN
- ProteinPeroxisomal membrane protein 11A
- GenePEX11A
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids247 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in peroxisomal proliferation and may regulate peroxisomes division (PubMed:9792670).
May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity).
Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).
May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity).
Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | peroxisomal membrane | |
Cellular Component | peroxisome | |
Cellular Component | protein-containing complex | |
Molecular Function | protein homodimerization activity | |
Biological Process | brown fat cell differentiation | |
Biological Process | peroxisome fission | |
Biological Process | peroxisome membrane biogenesis | |
Biological Process | peroxisome organization | |
Biological Process | regulation of peroxisome size | |
Biological Process | signal transduction |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namePeroxisomal membrane protein 11A
- Short namesHsPEX11p
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO75192
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Peroxisome membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-83 | Cytoplasmic | ||||
Sequence: MDAFTRFTNQTQGRDRLFRATQYTCMLLRYLLEPKAGKEKVVMKLKKLESSVSTGRKWFRLGNVVHAIQATEQSIHATDLVPR | ||||||
Transmembrane | 84-105 | Helical | ||||
Sequence: LCLTLANLNRVIYFICDTILWV | ||||||
Topological domain | 106-219 | Lumenal | ||||
Sequence: RSVGLTSGINKEKWRTRAAHHYYYSLLLSLVRDLYEISLQMKRVTCDRAKKEKSASQDPLWFSVAEEETEWLQSFLLLLFRSLKQHPPLLLDTVKNLCDILNPLDQLGIYKSNP | ||||||
Transmembrane | 220-239 | Helical | ||||
Sequence: GIIGLGGLVSSIAGMITVAY | ||||||
Topological domain | 240-247 | Cytoplasmic | ||||
Sequence: PQMKLKTR |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 9 | No effect on peroxisomal location. | ||||
Sequence: N → D | ||||||
Mutagenesis | 243-245 | No effect on peroxisomal location. | ||||
Sequence: KLK → SLS |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 478 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000105964 | 1-247 | Peroxisomal membrane protein 11A | |||
Sequence: MDAFTRFTNQTQGRDRLFRATQYTCMLLRYLLEPKAGKEKVVMKLKKLESSVSTGRKWFRLGNVVHAIQATEQSIHATDLVPRLCLTLANLNRVIYFICDTILWVRSVGLTSGINKEKWRTRAAHHYYYSLLLSLVRDLYEISLQMKRVTCDRAKKEKSASQDPLWFSVAEEETEWLQSFLLLLFRSLKQHPPLLLDTVKNLCDILNPLDQLGIYKSNPGIIGLGGLVSSIAGMITVAYPQMKLKTR |
Post-translational modification
Seems not to be N-glycosylated.
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 220-239 | Required for homodimerization, interaction with PEX11G, and peroxisomal localization | ||||
Sequence: GIIGLGGLVSSIAGMITVAY |
Sequence similarities
Belongs to the peroxin-11 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
O75192-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length247
- Mass (Da)28,353
- Last updated1998-11-01 v1
- ChecksumD904EC715271FF87
O75192-2
- Name2
- Differences from canonical
- 58-89: WFRLGNVVHAIQATEQSIHATDLVPRLCLTLA → S
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_054753 | 58-89 | in isoform 2 | |||
Sequence: WFRLGNVVHAIQATEQSIHATDLVPRLCLTLA → S |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB015594 EMBL· GenBank· DDBJ | BAA32533.1 EMBL· GenBank· DDBJ | mRNA | ||
AF093668 EMBL· GenBank· DDBJ | AAC78658.1 EMBL· GenBank· DDBJ | mRNA | ||
CR542046 EMBL· GenBank· DDBJ | CAG46843.1 EMBL· GenBank· DDBJ | mRNA | ||
CR542075 EMBL· GenBank· DDBJ | CAG46872.1 EMBL· GenBank· DDBJ | mRNA | ||
AK300978 EMBL· GenBank· DDBJ | BAG62600.1 EMBL· GenBank· DDBJ | mRNA | ||
AC013787 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC009697 EMBL· GenBank· DDBJ | AAH09697.1 EMBL· GenBank· DDBJ | mRNA |