O75038 · PLCH2_HUMAN
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
- GenePLCH2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1416 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:18361507).
This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).
This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Activity regulation
Activity is stimulated by GNB1:GNG2.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
14.4 μM | 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
12.6 μmol/min/mg |
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 182 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 184 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 186 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 188 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 193 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 341 | |||||
Sequence: H | ||||||
Binding site | 342 | Ca2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: N | ||||||
Binding site | 371 | Ca2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 373 | Ca2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Active site | 385 | |||||
Sequence: H | ||||||
Binding site | 420 | Ca2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 469 | substrate | ||||
Sequence: K | ||||||
Binding site | 471 | substrate | ||||
Sequence: K | ||||||
Binding site | 653 | substrate | ||||
Sequence: S | ||||||
Binding site | 680 | substrate | ||||
Sequence: R | ||||||
Binding site | 784 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 786 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 810 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 839 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 840 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 841 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylinositol metabolic process | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | phospholipase C-activating G protein-coupled receptor signaling pathway | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Chemistry
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO75038
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localized predominantly at the plasma membrane.
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 3,287 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000088507 | 1-1416 | UniProt | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 | |||
Sequence: MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPEGACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL | |||||||
Modified residue | 487 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 491 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 579 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 595 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 595 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 605 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 605 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1256 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1279 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in retina and kidney.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-155 | Necessary for plasma membrane localization | ||||
Sequence: MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMA | ||||||
Domain | 47-155 | PH | ||||
Sequence: GAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMA | ||||||
Domain | 169-204 | EF-hand 1 | ||||
Sequence: TRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVN | ||||||
Domain | 205-241 | EF-hand 2 | ||||
Sequence: LPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTR | ||||||
Domain | 326-471 | PI-PLC X-box | ||||
Sequence: QDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGK | ||||||
Compositional bias | 535-549 | Polar residues | ||||
Sequence: DPNNFSVSTLSPSGK | ||||||
Region | 535-620 | Disordered | ||||
Sequence: DPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTM | ||||||
Compositional bias | 551-568 | Basic and acidic residues | ||||
Sequence: GRKSKAEEDVESGEDAGA | ||||||
Domain | 626-740 | PI-PLC Y-box | ||||
Sequence: LSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMC | ||||||
Domain | 740-869 | C2 | ||||
Sequence: CQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEG | ||||||
Region | 905-1109 | Disordered | ||||
Sequence: GSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWR | ||||||
Compositional bias | 1010-1025 | Pro residues | ||||
Sequence: PAPGPGPPPPAAVPTS | ||||||
Region | 1121-1222 | Disordered | ||||
Sequence: YSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPR | ||||||
Compositional bias | 1139-1158 | Polar residues | ||||
Sequence: HRDSVSSSSSMSSSDTVIDL | ||||||
Region | 1315-1405 | Disordered | ||||
Sequence: ITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPEGACSVGHEGSVDAPAPSKGALGPAS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
O75038-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,416
- Mass (Da)154,668
- Last updated2007-11-13 v3
- Checksum05088ACD9C45AE87
O75038-2
- Name2
- Differences from canonical
- 1-41: MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPL → MEEPGPPGGLSQDQ
- 987-1156: DTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVI → GKAPAAVAEKSPVRVRPPRVLDGPGPAGMAATCMKCVVGSCAGVNTGGLQRERPPSPGPASRQAAIRQQPRARADSLGAPCCGLDPHAIPGRSREAPKGPGAWRQGPGGSGSMSSDSSSPDSPGIPERSPRWPEGACRQPGALQGEMSALFAQKLEEIRSKSPMFSAVRN
- 1157-1416: Missing
O75038-3
- Name3
- Differences from canonical
- 706-741: Missing
O75038-4
- Name4
- Differences from canonical
- 987-1211: DTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQ → GKAPAAVAEKSPVRVRPPRVLDGPGPAGMAATCMKCVVGSCAGVNTGGLQRERPPSPGPASRQAAIRQQPRARADSLGAPCCGLDPHAIPGRSREAPKGPGAWRQGPGGSGSMSSDSSSPDSPGIPERSPRWPEGACRQPGALQGEMSALFAQKLEEIRSKSPMFSAGKPLLPCVVLPHAPGMAGPGSPAAASAWTVSPRVLVLVALYPWHCLRGTLLPWLACGP
- 1212-1416: Missing
O75038-5
- Name5
- Differences from canonical
- 1-45: Missing
- 117-785: Missing
- 987-1211: DTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQ → GKAPAAVAEKSPVRVRPPRVLDGPGPAGMAATCMKCVVGSCAGVNTGGLQRERPPSPGPASRQAAIRQQPRARADSLGAPCCGLDPHAIPGRSREAPKGPGAWRQGPGGSGSMSSDSSSPDSPGIPERSPRWPEGACRQPGALQGEMSALFAQKLEEIRSKSPMFSAGKPLLPCVVLPHAPGMAGPGSPAAASAWTVSPRVLVLVALYPWHCLRGTLLPWLACGP
- 1212-1416: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_029068 | 1-41 | in isoform 2 | |||
Sequence: MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPL → MEEPGPPGGLSQDQ | ||||||
Alternative sequence | VSP_029067 | 1-45 | in isoform 5 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_029069 | 117-785 | in isoform 5 | |||
Sequence: Missing | ||||||
Sequence conflict | 209 | In isoform O75038-5; in Ref. 2; BAC56932 | ||||
Sequence: Q → L | ||||||
Compositional bias | 535-549 | Polar residues | ||||
Sequence: DPNNFSVSTLSPSGK | ||||||
Compositional bias | 551-568 | Basic and acidic residues | ||||
Sequence: GRKSKAEEDVESGEDAGA | ||||||
Sequence conflict | 559 | in Ref. 2; BAB84975 | ||||
Sequence: D → E | ||||||
Sequence conflict | 560 | in Ref. 2; BAB84975 | ||||
Sequence: V → M | ||||||
Alternative sequence | VSP_029070 | 706-741 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_029072 | 987-1156 | in isoform 2 | |||
Sequence: DTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVI → GKAPAAVAEKSPVRVRPPRVLDGPGPAGMAATCMKCVVGSCAGVNTGGLQRERPPSPGPASRQAAIRQQPRARADSLGAPCCGLDPHAIPGRSREAPKGPGAWRQGPGGSGSMSSDSSSPDSPGIPERSPRWPEGACRQPGALQGEMSALFAQKLEEIRSKSPMFSAVRN | ||||||
Alternative sequence | VSP_029071 | 987-1211 | in isoform 4 and isoform 5 | |||
Sequence: DTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQ → GKAPAAVAEKSPVRVRPPRVLDGPGPAGMAATCMKCVVGSCAGVNTGGLQRERPPSPGPASRQAAIRQQPRARADSLGAPCCGLDPHAIPGRSREAPKGPGAWRQGPGGSGSMSSDSSSPDSPGIPERSPRWPEGACRQPGALQGEMSALFAQKLEEIRSKSPMFSAGKPLLPCVVLPHAPGMAGPGSPAAASAWTVSPRVLVLVALYPWHCLRGTLLPWLACGP | ||||||
Sequence conflict | 1004 | In isoform O75038-4; in Ref. 2; BAB84975 | ||||
Sequence: P → L | ||||||
Compositional bias | 1010-1025 | Pro residues | ||||
Sequence: PAPGPGPPPPAAVPTS | ||||||
Compositional bias | 1139-1158 | Polar residues | ||||
Sequence: HRDSVSSSSSMSSSDTVIDL | ||||||
Alternative sequence | VSP_029073 | 1157-1416 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_029074 | 1212-1416 | in isoform 4 and isoform 5 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ176850 EMBL· GenBank· DDBJ | ABA12209.1 EMBL· GenBank· DDBJ | mRNA | ||
AK074149 EMBL· GenBank· DDBJ | BAB84975.1 EMBL· GenBank· DDBJ | mRNA | ||
AK122591 EMBL· GenBank· DDBJ | BAC56932.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AB007919 EMBL· GenBank· DDBJ | BAA32295.3 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL139246 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC019679 EMBL· GenBank· DDBJ | AAH19679.1 EMBL· GenBank· DDBJ | mRNA | ||
BC043358 EMBL· GenBank· DDBJ | AAH43358.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
BC050037 EMBL· GenBank· DDBJ | AAH50037.1 EMBL· GenBank· DDBJ | mRNA | ||
BC128207 EMBL· GenBank· DDBJ | AAI28208.1 EMBL· GenBank· DDBJ | mRNA |