O74339 · TAM41_SCHPO
- ProteinPhosphatidate cytidylyltransferase, mitochondrial
- Genetam41
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids393 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H+ = a CDP-1,2-diacyl-sn-glycerol + diphosphateThis reaction proceeds in the forward direction.
Cofactor
Pathway
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extrinsic component of mitochondrial inner membrane | |
Cellular Component | mitochondrial matrix | |
Cellular Component | mitochondrion | |
Molecular Function | cardiolipin binding | |
Molecular Function | phosphatidate cytidylyltransferase activity | |
Molecular Function | phosphatidic acid binding | |
Biological Process | cardiolipin biosynthetic process | |
Biological Process | CDP-diacylglycerol biosynthetic process | |
Biological Process | mitochondrial membrane organization |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidate cytidylyltransferase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Taphrinomycotina > Schizosaccharomycetes > Schizosaccharomycetales > Schizosaccharomycetaceae > Schizosaccharomyces
Accessions
- Primary accessionO74339
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000248361 | 1-393 | Phosphatidate cytidylyltransferase, mitochondrial | |||
Sequence: MIFGKTHFLSYNILRYSTKRWMNRHSYSHHAKCTVAQLLKQNLLTFENQRIQPEEELKENLTKVVNYFQAPIDVAVGYGSGVFRQAGYSQKENPMIDFIFQVEDPVKWHKINLQQNPSHYSFVKNFGPGFVSTLQESFGTGVYYNTHVEVEGNIIKYGVTSKKDVYEDLKNWNTMYLAGRFQKPVVILKGEDEFYKENSYNLSSALHVGLLMLADRFTEFDLYKTIVSLSYLGDIRMSFFAENPRKVENIVSKQIAFFRKLYLPLLYAEPGVHFIESSEVLKSMDPSDNSRYLSFHQNITKDSISRLLNGLPLNLVKILGLKPDTSSFEKCAELMLTNQISTRSLLISKSIKKLTSFSILTQSIKGIFTAGVIRSFVYVYAKLKKGLLSKWGR |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length393
- Mass (Da)45,235
- Last updated2012-03-21 v3
- Checksum379829C1A68BDCE4
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU329671 EMBL· GenBank· DDBJ | CAA20110.3 EMBL· GenBank· DDBJ | Genomic DNA | Frameshift |