O74339 · TAM41_SCHPO

Function

function

Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

GO annotations

AspectTerm
Cellular Componentextrinsic component of mitochondrial inner membrane
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular Functioncardiolipin binding
Molecular Functionphosphatidate cytidylyltransferase activity
Molecular Functionphosphatidic acid binding
Biological Processcardiolipin biosynthetic process
Biological ProcessCDP-diacylglycerol biosynthetic process
Biological Processmitochondrial membrane organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidate cytidylyltransferase, mitochondrial
  • EC number
  • Alternative names
    • CDP-diacylglycerol synthase (CDP-DAG synthase)
    • Mitochondrial translocator assembly and maintenance protein 41 homolog (TAM41)

Gene names

    • Name
      tam41
    • ORF names
      SPBC1A4.06c

Organism names

Accessions

  • Primary accession
    O74339

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002483611-393Phosphatidate cytidylyltransferase, mitochondrial

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the TAM41 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    393
  • Mass (Da)
    45,235
  • Last updated
    2012-03-21 v3
  • Checksum
    379829C1A68BDCE4
MIFGKTHFLSYNILRYSTKRWMNRHSYSHHAKCTVAQLLKQNLLTFENQRIQPEEELKENLTKVVNYFQAPIDVAVGYGSGVFRQAGYSQKENPMIDFIFQVEDPVKWHKINLQQNPSHYSFVKNFGPGFVSTLQESFGTGVYYNTHVEVEGNIIKYGVTSKKDVYEDLKNWNTMYLAGRFQKPVVILKGEDEFYKENSYNLSSALHVGLLMLADRFTEFDLYKTIVSLSYLGDIRMSFFAENPRKVENIVSKQIAFFRKLYLPLLYAEPGVHFIESSEVLKSMDPSDNSRYLSFHQNITKDSISRLLNGLPLNLVKILGLKPDTSSFEKCAELMLTNQISTRSLLISKSIKKLTSFSILTQSIKGIFTAGVIRSFVYVYAKLKKGLLSKWGR

Sequence caution

The sequence CAA20110.3 differs from that shown. Reason: Frameshift

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU329671
EMBL· GenBank· DDBJ
CAA20110.3
EMBL· GenBank· DDBJ
Genomic DNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

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