O73916 · SIX3_ORYLA

Function

function

Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is AES and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway. Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway.

Features

Showing features for dna binding.

TypeIDPosition(s)Description
DNA binding169-228Homeobox

GO annotations

AspectTerm
Cellular Componentnucleus
Cellular Componenttranscription regulator complex
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functiontranscription corepressor binding
Biological Processapoptotic process involved in development
Biological Processcell proliferation in forebrain
Biological Processepithelial cell maturation
Biological Processeye development
Biological Processforebrain dorsal/ventral pattern formation
Biological Processlens development in camera-type eye
Biological Processlens fiber cell apoptotic process
Biological Processlens fiber cell differentiation
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of neuron differentiation
Biological Processneuroblast differentiation
Biological Processneuroblast migration
Biological Processoptic vesicle morphogenesis
Biological Processpituitary gland development
Biological Processproximal/distal axis specification
Biological Processregulation of cell cycle phase transition
Biological Processregulation of cell population proliferation
Biological Processregulation of neural precursor cell proliferation
Biological Processregulation of neural retina development
Biological Processregulation of neuroblast proliferation
Biological Processregulation of transcription by RNA polymerase II
Biological Processtelencephalon development
Biological Processtelencephalon regionalization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Homeobox protein SIX3
  • Alternative names
    • Sine oculis homeobox homolog 3

Gene names

    • Name
      six3

Organism names

  • Taxonomic identifier
  • Strain
    • Carolina Biological
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    O73916

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000493021-272Homeobox protein SIX3

Interaction

Subunit

Interacts with GMNN.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region244-272Disordered

Sequence similarities

Belongs to the SIX/Sine oculis homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    272
  • Mass (Da)
    30,946
  • Last updated
    1998-08-01 v1
  • MD5 Checksum
    836A8403254563F150880AD91E239330
MVFRAPLDFISASRLLLPHFADAPPVLSRSRSPEHPPAGFLSLALPGLCFSATQIASVCETLEETGDIERLARFLWSLPVNTDGRDSISEHESVQRARAVVAFHTGCYRELYRILETHRFTRASHSKLQAMWLEAHYREAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRGLLREWYLQDPYPNPGKKRELAHATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHHRICPDSACTLSGGDSSERADGDTFLSVTDSDSDLDV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ000937
EMBL· GenBank· DDBJ
CAA04394.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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