O73732 · O73732_XENLA
- ProteinRho-associated protein kinase
- Generock2.L
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1370 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Activity regulation
Activated by RHOA binding. Inhibited by Y-27632.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | small GTPase binding | |
Biological Process | actin cytoskeleton organization | |
Biological Process | positive regulation of centrosome duplication | |
Biological Process | regulation of actin cytoskeleton organization | |
Biological Process | Rho protein signal transduction | |
Biological Process | rhythmic process | |
Biological Process | smooth muscle contraction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRho-associated protein kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionO73732
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 78-340 | Protein kinase | ||||
Sequence: YDVVKVIGRGAFGEVQLVRHKSSQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDEKHLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALNAIHSMGLIHRDVKPDNMLLDKYGHLKLADFGTCMKMDQTGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPEDVEISAHAKNLICAFLTDREVRLGRNGIEDIKQHPFF | ||||||
Domain | 343-411 | AGC-kinase C-terminal | ||||
Sequence: DQWNWDNIRETVAPVVPELASDIDTSNFDDIEDDKGDAETFQIPKAFAGNQLPFVGFTYYRENLLLSES | ||||||
Domain | 485-561 | REM-1 | ||||
Sequence: TTRQLEREKALLQHKNTEYQRKAENDADKKRSLENEVNSLKDQLEDMKRRNQNSQISNEKMNQLQRQLDEANAQLRT | ||||||
Region | 495-518 | Disordered | ||||
Sequence: LLQHKNTEYQRKAENDADKKRSLE | ||||||
Region | 524-543 | Disordered | ||||
Sequence: LKDQLEDMKRRNQNSQISNE | ||||||
Coiled coil | 629-1001 | |||||
Sequence: ISDLQGRISVLEEDLKKGKELLARADAEKQQLHERLAILEKEKSNMEIDMTYKLKALQQSVEKEESEHKATKARLADKNKIYQSIEETKSEAMKDMEKKLQEERVAKQRLENNLLETEKQYSMLDCDLKQAKQKINELEALKDKLSEDIKNLTLKAEQETQKRSLSQNDLKMQLQQVNCLKMSEKQLKQEVNHLTEIKLNLEKQNNELRKERVDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEVKGKMYKEVQQKVQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELAEKYATITSLEETNKTLTIDVGNLANEKEDLNNRLKEAHEQIQRLKEEENSV | ||||||
Domain | 967-1035 | RhoBD | ||||
Sequence: TIDVGNLANEKEDLNNRLKEAHEQIQRLKEEENSVVTIKTQFEKQLLTERTLKTQAVNKLAEIMNRKLP | ||||||
Coiled coil | 1044-1089 | |||||
Sequence: VRRKEKENRKLQLDLKSEREKFTQLVIKYQREMNDMQAQIADENQV | ||||||
Domain | 1134-1331 | PH | ||||
Sequence: ESRLEGWLSLPLRNAKKFGWNKKYVVVSSRKILFYDSEQDKELSNPSMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFQVDPLEKSNYICHKGHEFIPTLYHFPTSCDACMKPLWHMFKPPAALECRRCHIKCHKDHMDKKEEIIAPCKVNYDISTAKNLLLLANSTEEQQKWVSRLVKKIP | ||||||
Domain | 1242-1297 | Phorbol-ester/DAG-type | ||||
Sequence: GHEFIPTLYHFPTSCDACMKPLWHMFKPPAALECRRCHIKCHKDHMDKKEEIIAPC | ||||||
Region | 1330-1370 | Disordered | ||||
Sequence: IPKKPPASEHQARSSPRPPAKASLNQSMRRPSRQLPPNKPS | ||||||
Compositional bias | 1347-1363 | Polar residues | ||||
Sequence: PPAKASLNQSMRRPSRQ |
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,370
- Mass (Da)159,285
- Last updated1998-08-01 v1
- Checksum882639150AB6452D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1347-1363 | Polar residues | ||||
Sequence: PPAKASLNQSMRRPSRQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF037073 EMBL· GenBank· DDBJ | AAC06351.1 EMBL· GenBank· DDBJ | mRNA |