O73732 · O73732_XENLA

Function

function

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by RHOA binding. Inhibited by Y-27632.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site107ATP (UniProtKB | ChEBI)
Active site200Proton acceptor

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionprotein serine/threonine kinase activity
Molecular Functionsmall GTPase binding
Biological Processactin cytoskeleton organization
Biological Processpositive regulation of centrosome duplication
Biological Processregulation of actin cytoskeleton organization
Biological ProcessRho protein signal transduction
Biological Processrhythmic process
Biological Processsmooth muscle contraction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Rho-associated protein kinase
  • EC number

Gene names

    • Name
      rock2.L
    • Synonyms
      rock2
      , rocka-a
      , xROK

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    O73732

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Membrane
; Peripheral membrane protein
Nucleus

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

    • 394289Expressed in heart and 19 other cell types or tissues

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, region, coiled coil, compositional bias.

TypeIDPosition(s)Description
Domain78-340Protein kinase
Domain343-411AGC-kinase C-terminal
Domain485-561REM-1
Region495-518Disordered
Region524-543Disordered
Coiled coil629-1001
Domain967-1035RhoBD
Coiled coil1044-1089
Domain1134-1331PH
Domain1242-1297Phorbol-ester/DAG-type
Region1330-1370Disordered
Compositional bias1347-1363Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,370
  • Mass (Da)
    159,285
  • Last updated
    1998-08-01 v1
  • Checksum
    882639150AB6452D
MSPRQDEYMGTRWQTLEAILRDPRSPINVEGLLDGLNSIVLDLDFPALRKNKNIDNFLNRYEKIVREVRKLQMKAEDYDVVKVIGRGAFGEVQLVRHKSSQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDEKHLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALNAIHSMGLIHRDVKPDNMLLDKYGHLKLADFGTCMKMDQTGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPEDVEISAHAKNLICAFLTDREVRLGRNGIEDIKQHPFFKNDQWNWDNIRETVAPVVPELASDIDTSNFDDIEDDKGDAETFQIPKAFAGNQLPFVGFTYYRENLLLSESSQNCKEKKILCPTNERAVSTSCKKSINKLEEQLHNEMQTKDELEQKFRAVNLRLEKIVKELDEEASSRKNIESTTRQLEREKALLQHKNTEYQRKAENDADKKRSLENEVNSLKDQLEDMKRRNQNSQISNEKMNQLQRQLDEANAQLRTESDAAARLRKTQTEMSKQIQQLETNNREFQDKTCMLENAKLKLEKDFINLQSALESERRDRTQGSEVISDLQGRISVLEEDLKKGKELLARADAEKQQLHERLAILEKEKSNMEIDMTYKLKALQQSVEKEESEHKATKARLADKNKIYQSIEETKSEAMKDMEKKLQEERVAKQRLENNLLETEKQYSMLDCDLKQAKQKINELEALKDKLSEDIKNLTLKAEQETQKRSLSQNDLKMQLQQVNCLKMSEKQLKQEVNHLTEIKLNLEKQNNELRKERVDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEVKGKMYKEVQQKVQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELAEKYATITSLEETNKTLTIDVGNLANEKEDLNNRLKEAHEQIQRLKEEENSVVTIKTQFEKQLLTERTLKTQAVNKLAEIMNRKLPTKRGPDTDVRRKEKENRKLQLDLKSEREKFTQLVIKYQREMNDMQAQIADENQVRIELQMALDSKDSDIEQLRSQMLGLDSTSIGSGHGDTDAEDGFPESRLEGWLSLPLRNAKKFGWNKKYVVVSSRKILFYDSEQDKELSNPSMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFQVDPLEKSNYICHKGHEFIPTLYHFPTSCDACMKPLWHMFKPPAALECRRCHIKCHKDHMDKKEEIIAPCKVNYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPASEHQARSSPRPPAKASLNQSMRRPSRQLPPNKPS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1347-1363Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF037073
EMBL· GenBank· DDBJ
AAC06351.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp