O73683 · A4_TETFL
- ProteinAmyloid-beta A4 protein
- Geneapp
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids780 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O).
Features
Showing features for binding site, site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Golgi-associated vesicle | |
Cellular Component | membrane | |
Cellular Component | recycling endosome | |
Molecular Function | heparin binding | |
Molecular Function | serine-type endopeptidase inhibitor activity | |
Molecular Function | transition metal ion binding |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameAmyloid-beta A4 protein
- Alternative names
- Cleaved into 1 chains
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Tetraodontiformes > Tetradontoidea > Tetraodontidae > Tetraodon
Accessions
- Primary accessionO73683
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 19-711 | Extracellular | ||||
Sequence: AEVPTDVSMGLLAEPQVAMFCGKINMHINVQSGKWEPDPSGTKSCIGTKEGILQYCQEVYPELQITNVVEANQPVSIQNWCKKGRKQCRSHMHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMNQCESHLHWHTVAKESCGDRAMNLHDYGMLLPCGIDRFRGVEFVCCPAEAERDMDSTEKDADDSDVWWGGADNDYSDNSMVREPEPAEQQEETRPSVVEEEEEGEVAQEDDEEEEEVLDTDQDGDGEEDHEAADDEEEEEDVDEIDAFGESDDVDADEPTTNVAMTTTTTTTTTESVEEVVRMFCWAHADTGPCTASMPSWYFDAVDGRTMYELMYGGCGGNMNNFESEEYCLSVCSSVVPTDMPSSPDAVDHYLETPADENEHAHFQKAKESLEAKHRERMSQVMREWEEAERQAKNLPRADKKIVIQRFQEKVEALEQEAASERQQLVETHMARVEALLNDRRRLALENYLTALQQDPPRPRHVFSLLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRPQVLTHLRVIEERMNQSLGLLYKVPGVADDIQDQVELLQREQAEMAQQLANLQTDVRVSYGNDALMPDQELGDGQADLLPQEDTLGGVGFVHPESFNQLNTENQVEPVDSRPTFERGVPTRPVTGKSMEAVPELRMETEDRQSTEYEVHHQKLVFFAEDVGSNKGA | ||||||
Transmembrane | 712-732 | Helical | ||||
Sequence: IIGLMVGGVVIATVIVITLVM | ||||||
Topological domain | 733-780 | Cytoplasmic | ||||
Sequence: LRKKQYTSIHHGIIEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MGHSVAWLLLVAAASTLA | ||||||
Chain | PRO_0000000199 | 19-780 | Amyloid-beta A4 protein | |||
Sequence: AEVPTDVSMGLLAEPQVAMFCGKINMHINVQSGKWEPDPSGTKSCIGTKEGILQYCQEVYPELQITNVVEANQPVSIQNWCKKGRKQCRSHMHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMNQCESHLHWHTVAKESCGDRAMNLHDYGMLLPCGIDRFRGVEFVCCPAEAERDMDSTEKDADDSDVWWGGADNDYSDNSMVREPEPAEQQEETRPSVVEEEEEGEVAQEDDEEEEEVLDTDQDGDGEEDHEAADDEEEEEDVDEIDAFGESDDVDADEPTTNVAMTTTTTTTTTESVEEVVRMFCWAHADTGPCTASMPSWYFDAVDGRTMYELMYGGCGGNMNNFESEEYCLSVCSSVVPTDMPSSPDAVDHYLETPADENEHAHFQKAKESLEAKHRERMSQVMREWEEAERQAKNLPRADKKIVIQRFQEKVEALEQEAASERQQLVETHMARVEALLNDRRRLALENYLTALQQDPPRPRHVFSLLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRPQVLTHLRVIEERMNQSLGLLYKVPGVADDIQDQVELLQREQAEMAQQLANLQTDVRVSYGNDALMPDQELGDGQADLLPQEDTLGGVGFVHPESFNQLNTENQVEPVDSRPTFERGVPTRPVTGKSMEAVPELRMETEDRQSTEYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLRKKQYTSIHHGIIEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN | ||||||
Disulfide bond | 39↔63 | |||||
Sequence: CGKINMHINVQSGKWEPDPSGTKSC | ||||||
Disulfide bond | 74↔118 | |||||
Sequence: CQEVYPELQITNVVEANQPVSIQNWCKKGRKQCRSHMHIVVPYRC | ||||||
Disulfide bond | 99↔106 | |||||
Sequence: CKKGRKQC | ||||||
Disulfide bond | 134↔188 | |||||
Sequence: CKFLHQERMNQCESHLHWHTVAKESCGDRAMNLHDYGMLLPCGIDRFRGVEFVCC | ||||||
Disulfide bond | 145↔175 | |||||
Sequence: CESHLHWHTVAKESCGDRAMNLHDYGMLLPC | ||||||
Disulfide bond | 159↔187 | |||||
Sequence: CGDRAMNLHDYGMLLPCGIDRFRGVEFVC | ||||||
Disulfide bond | 327↔378 | |||||
Sequence: CWAHADTGPCTASMPSWYFDAVDGRTMYELMYGGCGGNMNNFESEEYCLSVC | ||||||
Disulfide bond | 336↔361 | |||||
Sequence: CTASMPSWYFDAVDGRTMYELMYGGC | ||||||
Glycosylation | 560 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Chain | PRO_0000000200 | 682-724 | Amyloid-beta protein | |||
Sequence: ETEDRQSTEYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIAT |
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 29-124 | GFLD subdomain | ||||
Sequence: LLAEPQVAMFCGKINMHINVQSGKWEPDPSGTKSCIGTKEGILQYCQEVYPELQITNVVEANQPVSIQNWCKKGRKQCRSHMHIVVPYRCLVGEFV | ||||||
Domain | 29-190 | E1 | ||||
Sequence: LLAEPQVAMFCGKINMHINVQSGKWEPDPSGTKSCIGTKEGILQYCQEVYPELQITNVVEANQPVSIQNWCKKGRKQCRSHMHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMNQCESHLHWHTVAKESCGDRAMNLHDYGMLLPCGIDRFRGVEFVCCPA | ||||||
Region | 132-190 | CuBD subdomain | ||||
Sequence: DKCKFLHQERMNQCESHLHWHTVAKESCGDRAMNLHDYGMLLPCGIDRFRGVEFVCCPA | ||||||
Compositional bias | 194-208 | Basic and acidic residues | ||||
Sequence: RDMDSTEKDADDSDV | ||||||
Region | 194-316 | Disordered | ||||
Sequence: RDMDSTEKDADDSDVWWGGADNDYSDNSMVREPEPAEQQEETRPSVVEEEEEGEVAQEDDEEEEEVLDTDQDGDGEEDHEAADDEEEEEDVDEIDAFGESDDVDADEPTTNVAMTTTTTTTTT | ||||||
Compositional bias | 220-236 | Basic and acidic residues | ||||
Sequence: NSMVREPEPAEQQEETR | ||||||
Compositional bias | 237-299 | Acidic residues | ||||
Sequence: PSVVEEEEEGEVAQEDDEEEEEVLDTDQDGDGEEDHEAADDEEEEEDVDEIDAFGESDDVDAD | ||||||
Compositional bias | 302-316 | Polar residues | ||||
Sequence: TTNVAMTTTTTTTTT | ||||||
Domain | 323-382 | BPTI/Kunitz inhibitor | ||||
Sequence: VRMFCWAHADTGPCTASMPSWYFDAVDGRTMYELMYGGCGGNMNNFESEEYCLSVCSSVV | ||||||
Domain | 392-583 | E2 | ||||
Sequence: AVDHYLETPADENEHAHFQKAKESLEAKHRERMSQVMREWEEAERQAKNLPRADKKIVIQRFQEKVEALEQEAASERQQLVETHMARVEALLNDRRRLALENYLTALQQDPPRPRHVFSLLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRPQVLTHLRVIEERMNQSLGLLYKVPGVADDIQDQVELL | ||||||
Region | 648-669 | Disordered | ||||
Sequence: NQVEPVDSRPTFERGVPTRPVT | ||||||
Motif | 767-772 | YENPXY motif | ||||
Sequence: YENPTY | ||||||
Region | 769-772 | Clathrin-binding | ||||
Sequence: NPTY |
Sequence similarities
Belongs to the APP family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length780
- Mass (Da)88,238
- Last updated1998-08-01 v1
- Checksum60071BE94520191D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 194-208 | Basic and acidic residues | ||||
Sequence: RDMDSTEKDADDSDV | ||||||
Compositional bias | 220-236 | Basic and acidic residues | ||||
Sequence: NSMVREPEPAEQQEETR | ||||||
Compositional bias | 237-299 | Acidic residues | ||||
Sequence: PSVVEEEEEGEVAQEDDEEEEEVLDTDQDGDGEEDHEAADDEEEEEDVDEIDAFGESDDVDAD | ||||||
Compositional bias | 302-316 | Polar residues | ||||
Sequence: TTNVAMTTTTTTTTT |