O70585 · DTNB_MOUSE

  • Protein
    Dystrobrevin beta
  • Gene
    Dtnb
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (PubMed:11585924).
May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:20530487).
May be required for proper maturation and function of a subset of inhibitory synapses (PubMed:16540561).

Features

Showing features for binding site.

165950100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site243Zn2+ 1 (UniProtKB | ChEBI)
Binding site246Zn2+ 1 (UniProtKB | ChEBI)
Binding site258Zn2+ 2 (UniProtKB | ChEBI)
Binding site261Zn2+ 2 (UniProtKB | ChEBI)
Binding site267Zn2+ 1 (UniProtKB | ChEBI)
Binding site270Zn2+ 1 (UniProtKB | ChEBI)
Binding site280Zn2+ 2 (UniProtKB | ChEBI)
Binding site284Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasal plasma membrane
Cellular Componentcytoplasm
Cellular Componentdendrite
Cellular ComponentGABA-ergic synapse
Cellular Componentinhibitory synapse
Cellular Componentnucleus
Cellular Componentplasma membrane
Cellular Componentpostsynapse
Cellular Componentpostsynaptic density
Cellular Componentsynapse
Molecular FunctionDNA binding
Molecular Functionphosphatase binding
Molecular Functionzinc ion binding
Biological Processsynaptic signaling

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Dystrobrevin beta
  • Short names
    DTN-B
    ; mDTN-BDTN-B
  • Alternative names
    • Beta-dystrobrevin

Gene names

    • Name
      Dtnb

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O70585
  • Secondary accessions
    • E9Q0F2
    • O70563
    • Q9CTZ1

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Postsynaptic density
Basal cell membrane
Postsynapse
Nucleus
Note: Localized at inhibitory synapses on the dendrites of cerebellar Purkinje cells.

Keywords

Phenotypes & Variants

Disruption phenotype

Homozygous knockout mice for Dtnb are viable and fertile, and are normal in appearance (PubMed:11585924, PubMed:16540561).
Double knockout mice for DTNA and DTNB genes have a mild myopathy plus synaptic defects and abnormal motor behavior (PubMed:16540561).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis11Does not affect interaction with Kif5A.
Mutagenesis11Reduces interaction with Kif5A.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 29 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00000868791-659Dystrobrevin beta
Modified residue11Phosphothreonine; by PKA and PKC
Modified residue69Phosphothreonine; by PKC
Modified residue179Phosphothreonine; by PKC
Modified residue212Phosphothreonine; by PKC
Modified residue394Phosphoserine
Modified residue424Phosphothreonine; by PKA

Post-translational modification

Phosphorylated by PKA (PubMed:17610895).
Phosphorylation at Thr-11 alters the interaction with KIF5A (PubMed:22978324).

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed mainly in liver and lung. Expressed in brain, namely in neurons of the cortex and hippocampus and in the dendrites, soma, and nuclei of pyramidal neurons of the hippocampus region CA1 (PubMed:11585924).
Expressed in kidney, namely in epithelial cells of renal tubules, collecting ducts, Bowman's capsules and glomeruli (PubMed:10893187).
Expressed in blood vessels and pia (PubMed:16540561).

Gene expression databases

Interaction

Subunit

Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2 (By similarity).
Binds DTNBP1 (PubMed:11316798).
Forms a specific complex composed of DMD, SNTB2 and SNTA1 in neuron; the interaction with SNTB2 and SNTA1 is DMD independent (PubMed:10545507).
Interacts with UTRN and dystrophin short form DP71 in the kidney and liver (PubMed:10893187).
Interacts with SNTB1, SNTB2 and SNTA1 in kidney and liver (PubMed:10893187).
Interacts with KIF5A (PubMed:14600269, PubMed:22978324).
Interacts with HMG20A and HMG20B (PubMed:20530487).
Interacts with OLFM1 (PubMed:17265465).
Interacts with PRKAR2B and PRKAR1A (PubMed:17610895).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O70585Kif5a P331754EBI-349714, EBI-349710

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for zinc finger, region, coiled coil, compositional bias.

TypeIDPosition(s)Description
Zinc finger238-294ZZ-type
Region369-418Syntrophin-binding region
Coiled coil429-519
Region520-562Disordered
Compositional bias542-556Polar residues
Region599-620Disordered
Compositional bias600-614Basic and acidic residues

Domain

The coiled coil domain may mediate the interaction with dystrophin.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing. Additional isoforms seem to exist.

O70585-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    659
  • Mass (Da)
    74,399
  • Last updated
    2011-06-28 v3
  • Checksum
    27AB3141A65797A8
MIEEGGNKRKTMAEKRQLFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNLHLVDIWNMIEAFRDNGLNTLDHSTEISVSRLETVISSIYYQLNKRLPSTHQISVEQSISLLLNFMVAAYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRYIFSQMSDSNGLMMFGKLDQFLKEALKLPTAVFEGPSFGYTEHAVRTCFPQQKKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVFHPVECSYCHCESMMGFRYRCQQCHNYQLCQNCFWRGHASGAHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPSREPPHPVFPEQPEKPLDLAHLVPPRPLTNMNDTVVSHMSSGVPTPTKRLQYSQDMPNLLADEHALIASYVARLQHCTRVLDSPSRLDEEHRLIARYAARLAAEAGNMTRPPTDASFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPMLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHGPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKELHSGAEAEEQAGTEKTREGLPPRGTFLSVFLLHTWTKLAGCQTHSTSRERSQAYGKWGGTA

O70585-2

  • Name
    2
  • Note
    May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 15 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q8K0N0Q8K0N0_MOUSEDtnb602
Q8C8Z9Q8C8Z9_MOUSEDtnb608
G3UZJ3G3UZJ3_MOUSEDtnb559
G3UYD1G3UYD1_MOUSEDtnb107
G3UYK9G3UYK9_MOUSEDtnb490
G3UYM7G3UYM7_MOUSEDtnb626
G3UYN2G3UYN2_MOUSEDtnb138
G3UZ85G3UZ85_MOUSEDtnb63
G3UZ87G3UZ87_MOUSEDtnb609
G3UXH9G3UXH9_MOUSEDtnb149
G3UXI3G3UXI3_MOUSEDtnb265
G3UXK0G3UXK0_MOUSEDtnb566
G3UXP7G3UXP7_MOUSEDtnb90
G3UY34G3UY34_MOUSEDtnb596
G3UX96G3UX96_MOUSEDtnb123

Sequence caution

The sequence CAA75752.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence CAA75752.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict, alternative sequence, compositional bias.

TypeIDPosition(s)Description
Sequence conflict412in Ref. 1; CAA75752
Sequence conflict465in Ref. 2; CAA05796 and 3; CAA09038
Alternative sequenceVSP_004227518in isoform 2
Compositional bias542-556Polar residues
Compositional bias600-614Basic and acidic residues
Alternative sequenceVSP_004228603-608in isoform 2
Alternative sequenceVSP_004229609-659in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y15742
EMBL· GenBank· DDBJ
CAA75752.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AJ003007
EMBL· GenBank· DDBJ
CAA05796.1
EMBL· GenBank· DDBJ
mRNA
AJ010204
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010205
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010206
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010207
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010208
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010209
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010210
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010211
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010212
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010213
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010214
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010215
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010216
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010217
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010218
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010219
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010220
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ010221
EMBL· GenBank· DDBJ
CAA09038.1
EMBL· GenBank· DDBJ
Genomic DNA
AC155273
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CR974568
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AK019068
EMBL· GenBank· DDBJ
-mRNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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