O70585 · DTNB_MOUSE
- ProteinDystrobrevin beta
- GeneDtnb
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids659 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:20530487).
May be required for proper maturation and function of a subset of inhibitory synapses (PubMed:16540561).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 243 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 246 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 258 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 261 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 267 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 270 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 280 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 284 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | basal plasma membrane | |
Cellular Component | cytoplasm | |
Cellular Component | dendrite | |
Cellular Component | GABA-ergic synapse | |
Cellular Component | inhibitory synapse | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Cellular Component | postsynapse | |
Cellular Component | postsynaptic density | |
Cellular Component | synapse | |
Molecular Function | DNA binding | |
Molecular Function | phosphatase binding | |
Molecular Function | zinc ion binding | |
Biological Process | synaptic signaling |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDystrobrevin beta
- Short namesDTN-B ; mDTN-BDTN-B
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO70585
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Double knockout mice for DTNA and DTNB genes have a mild myopathy plus synaptic defects and abnormal motor behavior (PubMed:16540561).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 11 | Does not affect interaction with Kif5A. | ||||
Sequence: T → A | ||||||
Mutagenesis | 11 | Reduces interaction with Kif5A. | ||||
Sequence: T → D |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 29 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000086879 | 1-659 | Dystrobrevin beta | |||
Sequence: MIEEGGNKRKTMAEKRQLFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNLHLVDIWNMIEAFRDNGLNTLDHSTEISVSRLETVISSIYYQLNKRLPSTHQISVEQSISLLLNFMVAAYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRYIFSQMSDSNGLMMFGKLDQFLKEALKLPTAVFEGPSFGYTEHAVRTCFPQQKKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVFHPVECSYCHCESMMGFRYRCQQCHNYQLCQNCFWRGHASGAHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPSREPPHPVFPEQPEKPLDLAHLVPPRPLTNMNDTVVSHMSSGVPTPTKRLQYSQDMPNLLADEHALIASYVARLQHCTRVLDSPSRLDEEHRLIARYAARLAAEAGNMTRPPTDASFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPMLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHGPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKELHSGAEAEEQAGTEKTREGLPPRGTFLSVFLLHTWTKLAGCQTHSTSRERSQAYGKWGGTA | ||||||
Modified residue | 11 | Phosphothreonine; by PKA and PKC | ||||
Sequence: T | ||||||
Modified residue | 69 | Phosphothreonine; by PKC | ||||
Sequence: T | ||||||
Modified residue | 179 | Phosphothreonine; by PKC | ||||
Sequence: T | ||||||
Modified residue | 212 | Phosphothreonine; by PKC | ||||
Sequence: T | ||||||
Modified residue | 394 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 424 | Phosphothreonine; by PKA | ||||
Sequence: T |
Post-translational modification
Phosphorylation at Thr-11 alters the interaction with KIF5A (PubMed:22978324).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in kidney, namely in epithelial cells of renal tubules, collecting ducts, Bowman's capsules and glomeruli (PubMed:10893187).
Expressed in blood vessels and pia (PubMed:16540561).
Gene expression databases
Interaction
Subunit
Binds DTNBP1 (PubMed:11316798).
Forms a specific complex composed of DMD, SNTB2 and SNTA1 in neuron; the interaction with SNTB2 and SNTA1 is DMD independent (PubMed:10545507).
Interacts with UTRN and dystrophin short form DP71 in the kidney and liver (PubMed:10893187).
Interacts with SNTB1, SNTB2 and SNTA1 in kidney and liver (PubMed:10893187).
Interacts with KIF5A (PubMed:14600269, PubMed:22978324).
Interacts with HMG20A and HMG20B (PubMed:20530487).
Interacts with OLFM1 (PubMed:17265465).
Interacts with PRKAR2B and PRKAR1A (PubMed:17610895).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O70585 | Kif5a P33175 | 4 | EBI-349714, EBI-349710 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for zinc finger, region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 238-294 | ZZ-type | ||||
Sequence: FHPVECSYCHCESMMGFRYRCQQCHNYQLCQNCFWRGHASGAHSNQHQMKEHSSWKS | ||||||
Region | 369-418 | Syntrophin-binding region | ||||
Sequence: NLLADEHALIASYVARLQHCTRVLDSPSRLDEEHRLIARYAARLAAEAGN | ||||||
Coiled coil | 429-519 | |||||
Sequence: NFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPMLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKA | ||||||
Region | 520-562 | Disordered | ||||
Sequence: QATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHGPQDSLSGVG | ||||||
Compositional bias | 542-556 | Polar residues | ||||
Sequence: RSTSAGSTPTHGPQD | ||||||
Region | 599-620 | Disordered | ||||
Sequence: LHSGAEAEEQAGTEKTREGLPP | ||||||
Compositional bias | 600-614 | Basic and acidic residues | ||||
Sequence: HSGAEAEEQAGTEKT |
Domain
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
O70585-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length659
- Mass (Da)74,399
- Last updated2011-06-28 v3
- Checksum27AB3141A65797A8
O70585-2
- Name2
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Computationally mapped potential isoform sequences
There are 15 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8K0N0 | Q8K0N0_MOUSE | Dtnb | 602 | ||
Q8C8Z9 | Q8C8Z9_MOUSE | Dtnb | 608 | ||
G3UZJ3 | G3UZJ3_MOUSE | Dtnb | 559 | ||
G3UYD1 | G3UYD1_MOUSE | Dtnb | 107 | ||
G3UYK9 | G3UYK9_MOUSE | Dtnb | 490 | ||
G3UYM7 | G3UYM7_MOUSE | Dtnb | 626 | ||
G3UYN2 | G3UYN2_MOUSE | Dtnb | 138 | ||
G3UZ85 | G3UZ85_MOUSE | Dtnb | 63 | ||
G3UZ87 | G3UZ87_MOUSE | Dtnb | 609 | ||
G3UXH9 | G3UXH9_MOUSE | Dtnb | 149 | ||
G3UXI3 | G3UXI3_MOUSE | Dtnb | 265 | ||
G3UXK0 | G3UXK0_MOUSE | Dtnb | 566 | ||
G3UXP7 | G3UXP7_MOUSE | Dtnb | 90 | ||
G3UY34 | G3UY34_MOUSE | Dtnb | 596 | ||
G3UX96 | G3UX96_MOUSE | Dtnb | 123 |
Sequence caution
Features
Showing features for sequence conflict, alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 412 | in Ref. 1; CAA75752 | ||||
Sequence: L → P | ||||||
Sequence conflict | 465 | in Ref. 2; CAA05796 and 3; CAA09038 | ||||
Sequence: S → F | ||||||
Alternative sequence | VSP_004227 | 518 | in isoform 2 | |||
Sequence: K → KEEEQKQA | ||||||
Compositional bias | 542-556 | Polar residues | ||||
Sequence: RSTSAGSTPTHGPQD | ||||||
Compositional bias | 600-614 | Basic and acidic residues | ||||
Sequence: HSGAEAEEQAGTEKT | ||||||
Alternative sequence | VSP_004228 | 603-608 | in isoform 2 | |||
Sequence: AEAEEQ → EVTPVS | ||||||
Alternative sequence | VSP_004229 | 609-659 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y15742 EMBL· GenBank· DDBJ | CAA75752.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AJ003007 EMBL· GenBank· DDBJ | CAA05796.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ010204 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010205 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010206 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010207 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010208 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010209 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010210 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010211 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010212 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010213 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010214 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010215 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010216 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010217 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010218 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010219 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010220 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ010221 EMBL· GenBank· DDBJ | CAA09038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC155273 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR974568 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AK019068 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |