O70421 · FZD1_MOUSE

  • Protein
    Frizzled-1
  • Gene
    Fzd1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor for Wnt proteins (PubMed:15923619).
Activated by WNT7B (PubMed:15923619).
Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (By similarity).
Contradictory results showing activation by WNT7B have been described for mouse (PubMed:15923619).
Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619).
The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:15923619).
A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable)

Caution

Activation by specific Wnt family members may depend on the cells used for the experiment. Contradictory results have been reported for activation by WNT7B in human and mouse.

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentplasma membrane
Molecular Functionfrizzled binding
Molecular FunctionG protein-coupled receptor activity
Molecular Functionidentical protein binding
Molecular FunctionPDZ domain binding
Molecular Functionprotein heterodimerization activity
Molecular Functionprotein homodimerization activity
Molecular FunctionWnt receptor activity
Molecular FunctionWnt-protein binding
Biological Processastrocyte-dopaminergic neuron signaling
Biological Processautocrine signaling
Biological Processcanonical Wnt signaling pathway
Biological Processcanonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
Biological Processcell-cell signaling
Biological Processendothelial cell differentiation
Biological Processhard palate development
Biological Processmembranous septum morphogenesis
Biological Processmuscular septum morphogenesis
Biological Processnegative regulation of BMP signaling pathway
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
Biological Processnon-canonical Wnt signaling pathway
Biological Processoutflow tract morphogenesis
Biological Processplanar cell polarity pathway involved in neural tube closure
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of neuron projection development
Biological Processpositive regulation of osteoblast differentiation
Biological Processpositive regulation of protein phosphorylation
Biological Processregulation of mesenchymal stem cell differentiation
Biological Processregulation of presynapse assembly
Biological Processresponse to xenobiotic stimulus
Biological Processventricular septum morphogenesis
Biological ProcessWnt signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Frizzled-1
  • Short names
    Fz-1; mFz1

Gene names

    • Name
      Fzd1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O70421
  • Secondary accessions
    • O08974
    • Q7TS82

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain69-317Extracellular
Transmembrane318-338Helical; Name=1
Topological domain339-349Cytoplasmic
Transmembrane350-370Helical; Name=2
Topological domain371-397Extracellular
Transmembrane398-418Helical; Name=3
Topological domain419-440Cytoplasmic
Transmembrane441-461Helical; Name=4
Topological domain462-484Extracellular
Transmembrane485-505Helical; Name=5
Topological domain506-531Cytoplasmic
Transmembrane532-552Helical; Name=6
Topological domain553-593Extracellular
Transmembrane594-614Helical; Name=7
Topological domain615-642Cytoplasmic

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 27 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-68
ChainPRO_000001297469-642Frizzled-1
Disulfide bond111↔172
Disulfide bond119↔165
Glycosylation125N-linked (GlcNAc...) asparagine
Disulfide bond156↔193
Disulfide bond182↔222
Disulfide bond186↔210
Glycosylation226N-linked (GlcNAc...) asparagine

Post-translational modification

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in chondrocytes.

Gene expression databases

Interaction

Subunit

Interacts with MYOC (By similarity).
Interacts with WNT7B (PubMed:15923619).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, domain, motif.

TypeIDPosition(s)Description
Region26-45Disordered
Region76-99Disordered
Domain106-225FZ
Motif620-625Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Motif640-642PDZ-binding

Domain

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
The FZ domain is involved in binding with Wnt ligands.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    642
  • Mass (Da)
    71,127
  • Last updated
    2011-07-27 v3
  • Checksum
    7674583F819014E2
MAEEAAPSESRAAGRLSLELCAEALPGRREEVGHEDTASHRRPRADPRRWASGLLLLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQPQQSGQQYNGERGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGTVERGKFSCPRALRVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict122in Ref. 1; AAC12873
Sequence conflict246in Ref. 1; AAC12873
Sequence conflict341in Ref. 1; AAC12873
Sequence conflict352in Ref. 1; AAC12873
Sequence conflict393in Ref. 1; AAC12873
Sequence conflict474in Ref. 1; AAC12873
Sequence conflict615in Ref. 1; AAC12873

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF054623
EMBL· GenBank· DDBJ
AAC12873.2
EMBL· GenBank· DDBJ
mRNA
AK143101
EMBL· GenBank· DDBJ
BAE25269.1
EMBL· GenBank· DDBJ
mRNA
CH466600
EMBL· GenBank· DDBJ
EDL14633.1
EMBL· GenBank· DDBJ
Genomic DNA
BC053010
EMBL· GenBank· DDBJ
AAH53010.1
EMBL· GenBank· DDBJ
mRNA
AF005202
EMBL· GenBank· DDBJ
AAC01952.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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