O70352 · CD82_RAT

Function

function

Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization. Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC. Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4. Modulates adhesion and suppresses cell migration through other integrins such as the alpha6/ITGA6 and beta1/ITGB1. Decreases cell-associated plasminogen activation by interfering with the interaction between urokinase-type plasminogen activator/PLAU and its receptor PLAUR (By similarity).
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Plays a role in the restrains phagocyte migration but supports macrophage activation (By similarity).
Plays a role in TLR9 trafficking to acidified CpG-containing compartments by controlling interaction between TLR9 and VAMP3 and subsequent myddosome assembly (By similarity).
Inhibits LPS-induced inflammatory response by preventing binding of LPS to TLR4 on the cell surface (By similarity).
Plays a role in the activation of macrophages into anti-inflammatory phenotypes (By similarity).
Independently of Toll-like receptor (TLR) signaling, is recruited to pathogen-containing phagosomes prior to fusion with lysosomes and participates in antigen presentation (By similarity).
Acts also to control angiogenesis and switch angiogenic milieu to quiescent state by binding and sequestering VEGFA and PDGFA to inhibit the signaling they trigger via their respective cell surface receptor (By similarity).

GO annotations

AspectTerm
Cellular Componentplasma membrane

Names & Taxonomy

Protein names

  • Recommended name
    CD82 antigen
  • Alternative names
    • Metastasis suppressor Kangai-1 homolog
  • CD Antigen Name
    • CD82

Gene names

    • Name
      Cd82
    • Synonyms
      Kai1

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    O70352

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-11Cytoplasmic
Transmembrane12-32Helical
Topological domain33-53Extracellular
Transmembrane54-72Helical
Topological domain73-83Cytoplasmic
Transmembrane84-110Helical
Topological domain111-227Extracellular
Transmembrane228-249Helical
Topological domain250-266Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, lipidation, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002192281-266CD82 antigen
Lipidation5S-palmitoyl cysteine
Lipidation74S-palmitoyl cysteine
Glycosylation127N-linked (GlcNAc...) asparagine
Glycosylation131N-linked (GlcNAc...) asparagine
Glycosylation157N-linked (GlcNAc...) asparagine
Glycosylation166N-linked (GlcNAc...) asparagine
Glycosylation197N-linked (GlcNAc...) asparagine

Post-translational modification

Palmitoylated. Palmitoylation contributes to oligomerization and surface expression.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Forms homooligomers. Interacts directly with IGSF8. Interacts with EGFR (By similarity).
Interacts with VEGFA and PDGFA (By similarity).
Interacts with ITGA4. Interacts with ITGA6; this interaction reduces ITGA6 cell surface expression. Interacts with ITGB1. Interacts with TLR4; this interaction inhibits TLR4-mediated signaling pathway (By similarity).
Interacts with TLR9 (By similarity).
Interacts with PLAUR (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    266
  • Mass (Da)
    29,487
  • Last updated
    1998-08-01 v1
  • Checksum
    D6E10AB5AA348474
MGAGCVKVTKYFLFLFNLLFFILGAVILGFGVWILADKSSFISVLQTSSSSLQVGAYVFIGVGAITMLMGFLGCIGAVNEVRCLLGLYFVFLLLILIAQVTVEVLFYFNANKLKQEMGNTVMDIIQNYSVNASSSREEAWDYVQAQVKCCGWVSPSNWTRNPVLKNSTKTTYPCSCEKTKEEDNQLIVKKGFCESDNSTASENSPEDWPVHPEGCMEKAQAWLQENFGILLGVCAGVAVIELLGLFLSICLCRYIHSEDYSKVPKY

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6GJM9A0A8I6GJM9_RATCd82271
F7EV99F7EV99_RATCd82264
A6HNI9A6HNI9_RATCd82266
A0A8I5ZP15A0A8I5ZP15_RATCd82260

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF049882
EMBL· GenBank· DDBJ
AAC05159.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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