O70340 · NPTX2_MOUSE
- ProteinNeuronal pentraxin-2
- GeneNptx2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids429 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).
Cofactor
Note: Binds 2 calcium ions per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 275 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 353 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 353 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 354 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 355 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 355 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 365 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extrinsic component of postsynaptic specialization membrane | |
Cellular Component | glutamatergic synapse | |
Cellular Component | presynapse | |
Cellular Component | synapse | |
Cellular Component | synaptic cleft | |
Molecular Function | carbohydrate binding | |
Molecular Function | metal ion binding | |
Biological Process | associative learning | |
Biological Process | neurotransmitter receptor localization to postsynaptic specialization membrane |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNeuronal pentraxin-2
- Short namesNP2
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO70340
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-14 | |||||
Sequence: MLALLTVGVALAVA | ||||||
Chain | PRO_0000023552 | 15-429 | Neuronal pentraxin-2 | |||
Sequence: AGRAQDSPIPGSRFVCTALPPEAARAGCPLPAMPMQGGALSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTGKLARCEGLAGGKARGTGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLELQLRTNVSNAGLPSDFREVLQRRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICITWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIINIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL | ||||||
Glycosylation | 146 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 187 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 251↔311 | |||||
Sequence: CLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHIC | ||||||
Glycosylation | 391 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 221-422 | Pentraxin (PTX) | ||||
Sequence: DAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICITWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIINIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETC |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length429
- Mass (Da)47,137
- Last updated1998-08-01 v1
- Checksum638EED14C4CECA28
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF049124 EMBL· GenBank· DDBJ | AAC05131.1 EMBL· GenBank· DDBJ | mRNA | ||
AF318618 EMBL· GenBank· DDBJ | AAK06745.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC026054 EMBL· GenBank· DDBJ | AAH26054.1 EMBL· GenBank· DDBJ | mRNA |