O70291 · GRK4_MOUSE
- ProteinG protein-coupled receptor kinase 4
- GeneGrk4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids574 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Specifically phosphorylates the activated forms of G protein-coupled receptors.
Catalytic activity
- [G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H+
Activity regulation
Inhibited by heparin.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell cortex | |
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | dendrite | |
Cellular Component | neuronal cell body | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | protein kinase activity | |
Molecular Function | rhodopsin kinase activity | |
Biological Process | desensitization of G protein-coupled receptor signaling pathway | |
Biological Process | G protein-coupled receptor internalization | |
Biological Process | regulation of signal transduction | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameG protein-coupled receptor kinase 4
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO70291
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000085968 | 1-574 | G protein-coupled receptor kinase 4 | |||
Sequence: MELENFVANNLLLKARLGFNKQTGRSKKWRELLKFPPVSMCTELRWSIEKDFSSLCDKQPIGRLLFRQFCDTKPDLKRCIEFLDAVAEYEVTIEEEQREFGLAIFSRFFKEKSEVPLPEIPPDIVKECKWNLKQNSPSQNVFEECAGIVCKYLSETPFEEYQESTYFNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIFKDINFSRLEANMLDPPFIPDPQAIYCRNILDIGQFSVVKGVNLDTNDEIFYAEFATGSVTIPWQNEMIESGCFKDLNENEDDLSSLEKYKMCSSILRPKRNFFRRLFRRTGCLNIALSEEREPTEH | ||||||
Modified residue | 484 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Palmitoylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-153 | N-terminal | ||||
Sequence: MELENFVANNLLLKARLGFNKQTGRSKKWRELLKFPPVSMCTELRWSIEKDFSSLCDKQPIGRLLFRQFCDTKPDLKRCIEFLDAVAEYEVTIEEEQREFGLAIFSRFFKEKSEVPLPEIPPDIVKECKWNLKQNSPSQNVFEECAGIVCKYL | ||||||
Domain | 51-171 | RGS | ||||
Sequence: DFSSLCDKQPIGRLLFRQFCDTKPDLKRCIEFLDAVAEYEVTIEEEQREFGLAIFSRFFKEKSEVPLPEIPPDIVKECKWNLKQNSPSQNVFEECAGIVCKYLSETPFEEYQESTYFNRFL | ||||||
Domain | 186-448 | Protein kinase | ||||
Sequence: FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIF | ||||||
Domain | 449-514 | AGC-kinase C-terminal | ||||
Sequence: KDINFSRLEANMLDPPFIPDPQAIYCRNILDIGQFSVVKGVNLDTNDEIFYAEFATGSVTIPWQNE |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length574
- Mass (Da)66,928
- Last updated2011-07-27 v2
- Checksum7D7D6F46C9C044B6
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 6 | in Ref. 1; AAC09266 | ||||
Sequence: F → M |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF040745 EMBL· GenBank· DDBJ | AAC09266.1 EMBL· GenBank· DDBJ | mRNA | ||
AK132685 EMBL· GenBank· DDBJ | BAE21301.1 EMBL· GenBank· DDBJ | mRNA | ||
CH466524 EMBL· GenBank· DDBJ | EDL37466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC150691 EMBL· GenBank· DDBJ | AAI50692.1 EMBL· GenBank· DDBJ | mRNA |