O70283 · WNT2B_MOUSE

  • Protein
    Protein Wnt-2b
  • Gene
    Wnt2b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:19686689).
Plays a redundant role in embryonic lung development (PubMed:19686689).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentintracellular membrane-bounded organelle
Molecular Functioncytokine activity
Molecular Functionfrizzled binding
Molecular Functionsignaling receptor binding
Biological Processanimal organ morphogenesis
Biological Processcanonical Wnt signaling pathway
Biological Processcell fate commitment
Biological Processcell-cell signaling
Biological Processcellular response to starvation
Biological Processchondrocyte differentiation
Biological Processforebrain regionalization
Biological Processhematopoietic stem cell proliferation
Biological Processlung induction
Biological Processmale gonad development
Biological Processmesenchymal-epithelial cell signaling
Biological Processneuron differentiation
Biological Processpositive regulation of branching involved in ureteric bud morphogenesis
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein Wnt-2b
  • Alternative names
    • Protein Wnt-13

Gene names

    • Name
      Wnt2b
    • Synonyms
      Wnt13

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • NIH Swiss
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O70283
  • Secondary accessions
    • O88530
    • Q544L3

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

No visible phenotype at birth (PubMed:19686689).
Combined disruption of Wnt2 and Wnt2b leads to lung agenesis (PubMed:19686689).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 20 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, signal, disulfide bond, glycosylation, lipidation.

TypeIDPosition(s)Description
ChainPRO_0000041414?-389Protein Wnt-2b
Signal1-?
Disulfide bond105↔116
Glycosylation115N-linked (GlcNAc...) asparagine
Disulfide bond156↔164
Disulfide bond166↔186
Disulfide bond235↔249
Disulfide bond237↔244
Lipidation241O-palmitoleoyl serine; by PORCN
Glycosylation281N-linked (GlcNAc...) asparagine
Disulfide bond307↔338
Disulfide bond323↔333
Disulfide bond337↔377
Disulfide bond353↔368
Disulfide bond355↔365
Disulfide bond360↔361

Post-translational modification

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Detected at the dorsal midline at the level of the diencephalon and mesencephalon at 9.5 dpc. Detected at the level of the optic and otic vesicles at 9.5 dpc (PubMed:9545553).
Detected in the lateral plate mesoderm surrounding the ventral aspect of the anterior foregut at 9.5 dpc (PubMed:19686689).
Detected in the mesothelium encasing the lung, and at lower levels in the distal mesenchyme from 12.5 dpc to 14.5 dpc (PubMed:19686689).

Gene expression databases

Interaction

Subunit

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity).
Interacts with FZD4 and FZD5 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-33Disordered

Sequence similarities

Belongs to the Wnt family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    389
  • Mass (Da)
    43,753
  • Last updated
    2011-07-27 v3
  • Checksum
    64F956BB9A00CEEB
MLKLQGEDEAAQLAPRRARVPVPRPTAPDVSPSSARLGLACLLLLLLLTLPARVDTSWWYIGALGARVICDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRAMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGAVQVTATQDGANFTAARQGYRHATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCKAPKKAEWLDQT

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict313in Ref. 1; AAC25397

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF070988
EMBL· GenBank· DDBJ
AAC25397.1
EMBL· GenBank· DDBJ
mRNA
AK035653
EMBL· GenBank· DDBJ
BAC29139.1
EMBL· GenBank· DDBJ
mRNA
CH466608
EMBL· GenBank· DDBJ
EDL07557.1
EMBL· GenBank· DDBJ
Genomic DNA
BC119276
EMBL· GenBank· DDBJ
AAI19277.1
EMBL· GenBank· DDBJ
mRNA
BC119278
EMBL· GenBank· DDBJ
AAI19279.1
EMBL· GenBank· DDBJ
mRNA
AF038384
EMBL· GenBank· DDBJ
AAC40123.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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