the Fox transcription factor binding motif was frequently observed within EWS-FLI1 peaks and Foxq1 was identified as the cooperative partner that interacts with the EWS portion of EWS-FLI1.
data reveal that FOXQ1 acts as a critical mediator of BRAF(V600E)-dependent regulation of MITF levels thus providing a novel link between two major signal transduction pathways controlling MITF and differentiation in melanocytic cells.
FOXQ1 is a novel factor involved in regulating hepatic gluconeogenesis and the decreased FOXQ1 expression in liver may contribute to the development of type 2 diabetes.
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