O70200 · AIF1_MOUSE

  • Protein
    Allograft inflammatory factor 1
  • Gene
    Aif1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Features

Showing features for binding site.

114720406080100120140
TypeIDPosition(s)Description
Binding site58Ca2+ 1 (UniProtKB | ChEBI)
Binding site60Ca2+ 1 (UniProtKB | ChEBI)
Binding site62Ca2+ 1 (UniProtKB | ChEBI)
Binding site64Ca2+ 1 (UniProtKB | ChEBI)
Binding site98Ca2+ 2 (UniProtKB | ChEBI)
Binding site100Ca2+ 2 (UniProtKB | ChEBI)
Binding site105Ca2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentactin filament
Cellular Componentcell projection
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentglial cell projection
Cellular Componentlamellipodium
Cellular Componentnucleus
Cellular Componentperikaryon
Cellular Componentperinuclear region of cytoplasm
Cellular Componentphagocytic cup
Cellular Componentruffle
Cellular Componentruffle membrane
Molecular Functionactin filament binding
Molecular Functioncalcium ion binding
Biological Processactin crosslink formation
Biological Processactin filament bundle assembly
Biological Processactin filament polymerization
Biological Processcellular response to oxidative stress
Biological Processcellular response to type II interferon
Biological Processinflammatory response
Biological Processmicroglial cell activation
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of smooth muscle cell chemotaxis
Biological Processnegative regulation of smooth muscle cell proliferation
Biological Processparallel actin filament bundle assembly
Biological Processphagocytosis, engulfment
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of chemokine production
Biological Processpositive regulation of fibroblast growth factor production
Biological Processpositive regulation of G1/S transition of mitotic cell cycle
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of monocyte chemotaxis
Biological Processpositive regulation of muscle hyperplasia
Biological Processpositive regulation of nitric oxide biosynthetic process
Biological Processpositive regulation of protein phosphorylation
Biological Processpositive regulation of smooth muscle cell chemotaxis
Biological Processpositive regulation of smooth muscle cell proliferation
Biological Processpositive regulation of T cell migration
Biological Processpositive regulation of T cell proliferation
Biological ProcessRac protein signal transduction
Biological Processruffle assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Allograft inflammatory factor 1
  • Short names
    AIF-1
  • Alternative names
    • Ionized calcium-binding adapter molecule 1

Gene names

    • Name
      Aif1
    • Synonyms
      Iba1

Organism names

  • Taxonomic identifier
  • Strains
    • 129
    • 129/SvJ
    • 129/Sv
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O70200

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00000738672-147Allograft inflammatory factor 1
Modified residue11N6-acetyllysine

Post-translational modification

Phosphorylated on serine residues.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Abundantly expressed in the testis, moderately in the spleen and lymph nodes and at low levels in the liver and thymus. Detected in macrophages.

Gene expression databases

Interaction

Subunit

Homodimer (Potential). Monomer. Interacts with LCP1.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain45-80EF-hand 1
Domain81-115EF-hand 2; degenerate
Region128-147Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    147
  • Mass (Da)
    16,911
  • Last updated
    1998-08-01 v1
  • Checksum
    D8974825C153D3CA
MSQSRDLQGGKAFGLLKAQQEERLEGINKQFLDDPKYSNDEDLPSKLEAFKVKYMEFDLNGNGDIDIMSLKRMLEKLGVPKTHLELKRLIREVSSGSEETFSYSDFLRMMLGKRSAILRMILMYEEKNKEHKRPTGPPAKKAISELP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
G3UYJ2G3UYJ2_MOUSEAif1128

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB013745
EMBL· GenBank· DDBJ
BAA28216.1
EMBL· GenBank· DDBJ
mRNA
AB036423
EMBL· GenBank· DDBJ
BAB20758.1
EMBL· GenBank· DDBJ
Genomic DNA
D86382
EMBL· GenBank· DDBJ
BAA86387.1
EMBL· GenBank· DDBJ
mRNA
AF074959
EMBL· GenBank· DDBJ
AAC25604.1
EMBL· GenBank· DDBJ
mRNA
U82792
EMBL· GenBank· DDBJ
AAC24189.1
EMBL· GenBank· DDBJ
Genomic DNA
AK006184
EMBL· GenBank· DDBJ
BAB24445.1
EMBL· GenBank· DDBJ
mRNA
AK006562
EMBL· GenBank· DDBJ
BAB24654.1
EMBL· GenBank· DDBJ
mRNA
AF109719
EMBL· GenBank· DDBJ
AAC82481.1
EMBL· GenBank· DDBJ
Genomic DNA
BC021539
EMBL· GenBank· DDBJ
AAH21539.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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